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- W4293240468 abstract "Abstract Purpose: To retrospectively investigate changes of aqueous humor inflammatory cytokines and angiogenic biomarkers levels in response to intravitreal injection of Conbercept (IVC) treatment for the management of polypoidal choroidal vasculopathy (PCV). Methods: Thirty eyes of 30 PCV patients were enrolled and were received with three consecutive monthly injections of Conbercept. Aqueous humour was collected before the first and third injections. The concentrations of 4 inflammatory cytokines (interleukin (IL)-2, IL-6, IL-10, monocyte chemotactic protein (MCP)-1) and 4 angiogenic biomarkers (vascular endothelial growth factor (VEGF), angiopoietin 2, endothelin 1, IL-8) in the aqueous humor samples of both groups were measured. Results: Concentrations of 2 inflammatory cytokines (IL-10, MCP-1) and 4 angiogenic biomarkers (VEGF, angiopoietin 2, endothelin 1, IL-8) in aqueous humors were significantly higher in eyes of PCV compared with control eyes (all p <0.05), while concentrations of IL-2 and IL-6 did not differ significantly between the two groups (all p >0.05). After IVC treatment, concentrations of 4 cytokines (IL-2, IL-6, IL-10, MCP-1) and VEGF in aqueous humors were significantly decreased in eyes of PCV compared with baseline (all p <0.05), no other angiogenic biomarker (angiopoietin 2, endothelin 1 or IL-8) concentration was significantly altered by IVC treatment. Conclusions: PCV has remarkably distinct inflammatory cytokines and angiogenic biomarkers levels in the aqueous humor. After consecutive Conbercept injection for two monthly, IL-2, IL-6, IL-10, MCP-1 and VEGF levels in aqueous humors from eyes of PCV were strongly inhibited. Our findings suggest that some key inflammatory cytokines and angiogenic biomarkers may be paticipated in the pathogenesis of PCV." @default.
- W4293240468 created "2022-08-27" @default.
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- W4293240468 date "2022-08-25" @default.
- W4293240468 modified "2023-09-27" @default.
- W4293240468 title "Aqueous Humor Cytokines Levels in Polypoidal Choroidal Vasculopathy before and after intravitreal injection of Conbercept" @default.
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- W4293240468 doi "https://doi.org/10.21203/rs.3.rs-1966543/v1" @default.
- W4293240468 hasPublicationYear "2022" @default.
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