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- W4293240615 abstract "Abstract Unawareness of memory deficits is an early manifestation in patients with Alzheimer’s disease (AD). This intriguing behavior constitutes a form of anosognosia and has neural mechanisms that remain largely unknown. Here, we hypothesized that it may result from a failure in the error-monitoring system, which would prevent AD patients from being aware of their own memory impairment. To investigate, we measured event-related potentials (ERPs) evoked by erroneous responses during a memory task in two groups of amyloid positive individuals who had only subjective memory complaints at study entry: those who progressed to AD within the five-year study period (PROG group); and those who remained cognitively normal throughout the study (CTRL group). A significant reduction in the amplitude of the positivity error (Pe), an ERP related to error awareness, was observed in the PROG group at the time of AD diagnosis, in intra-group analysis, as well as when compared with the CTRL group, in inter-group analysis. To our knowledge, the results of this study reveal for the first time the emergence of a failure in the error-monitoring system from the very early stages of AD, strongly suggesting that a neurophysiological impairment in this system may be critical for the lack of awareness of memory deficits that often delays AD diagnosis. Hence, this study further suggests that a reduced Pe amplitude may constitute a potential neural biomarker of prodromal AD." @default.
- W4293240615 created "2022-08-27" @default.
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- W4293240615 date "2022-04-28" @default.
- W4293240615 modified "2023-10-18" @default.
- W4293240615 title "Can a failure in the error monitoring system explain unawareness of memory deficits in Alzheimer’s disease?" @default.
- W4293240615 doi "https://doi.org/10.21203/rs.3.rs-1577671/v1" @default.
- W4293240615 hasPublicationYear "2022" @default.
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