Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293282335> ?p ?o ?g. }
- W4293282335 endingPage "3510" @default.
- W4293282335 startingPage "3498" @default.
- W4293282335 abstract "The nucleus reuniens (RE) and the perirhinal cortex (PRC) are two major relay stations that interconnect the hippocampus (HPC) and the medial prefrontal cortex (mPFC). Previous studies have shown that both the RE and the PRC are involved in the acquisition of trace fear conditioning. However, the respective contribution of the two regions is unclear. In this study, we used pharmacological approach to compare their roles. Our data suggested that inactivation of the RE or the PRC during conditioning partially impaired, whereas inactivation of both areas totally abolished, the encoding of trace fear. We next examined whether the impaired encoding of trace fear under RE inactivation can be rescued with enhanced cholinergic tone in the PRC, and vice versa. Against our hypothesis, regardless of whether the RE was on-line or not, animals failed to encode trace fear when further engaging cholinergic activities in the PRC. Conversely, depending on PRC activation level during conditioning, further recruiting cholinergic activities in the RE led to a down-shift of fear response during retrieval. Our results revealed that the RE and the PRC were necessary for the encoding of trace fear. Moreover, there was differential importance of cholinergic modulation during the process." @default.
- W4293282335 created "2022-08-27" @default.
- W4293282335 creator A5011951821 @default.
- W4293282335 creator A5073355185 @default.
- W4293282335 date "2022-08-12" @default.
- W4293282335 modified "2023-10-13" @default.
- W4293282335 title "Differential roles of nucleus reuniens and perirhinal cortex in Pavlovian trace fear conditioning in rats" @default.
- W4293282335 cites W1585013154 @default.
- W4293282335 cites W1940098476 @default.
- W4293282335 cites W1964179430 @default.
- W4293282335 cites W1965453247 @default.
- W4293282335 cites W1965545113 @default.
- W4293282335 cites W1966375501 @default.
- W4293282335 cites W1968906215 @default.
- W4293282335 cites W1970319251 @default.
- W4293282335 cites W1975307569 @default.
- W4293282335 cites W1978314317 @default.
- W4293282335 cites W1981683953 @default.
- W4293282335 cites W1988500565 @default.
- W4293282335 cites W1990588924 @default.
- W4293282335 cites W1996526301 @default.
- W4293282335 cites W1999077789 @default.
- W4293282335 cites W2003255563 @default.
- W4293282335 cites W2010288797 @default.
- W4293282335 cites W2011566601 @default.
- W4293282335 cites W2015057988 @default.
- W4293282335 cites W2020549903 @default.
- W4293282335 cites W2035851384 @default.
- W4293282335 cites W2035946761 @default.
- W4293282335 cites W2043017439 @default.
- W4293282335 cites W2043048346 @default.
- W4293282335 cites W2045542193 @default.
- W4293282335 cites W2046665948 @default.
- W4293282335 cites W2055351412 @default.
- W4293282335 cites W2055566656 @default.
- W4293282335 cites W2056860237 @default.
- W4293282335 cites W2057563464 @default.
- W4293282335 cites W2058134404 @default.
- W4293282335 cites W2060927124 @default.
- W4293282335 cites W2063818968 @default.
- W4293282335 cites W2064881311 @default.
- W4293282335 cites W2065808106 @default.
- W4293282335 cites W2070121921 @default.
- W4293282335 cites W2071821499 @default.
- W4293282335 cites W2081801828 @default.
- W4293282335 cites W2083922453 @default.
- W4293282335 cites W2088396693 @default.
- W4293282335 cites W2091485403 @default.
- W4293282335 cites W2095056606 @default.
- W4293282335 cites W2100243927 @default.
- W4293282335 cites W2103194016 @default.
- W4293282335 cites W2104580392 @default.
- W4293282335 cites W2111627644 @default.
- W4293282335 cites W2126220747 @default.
- W4293282335 cites W2130674184 @default.
- W4293282335 cites W2137070227 @default.
- W4293282335 cites W2144116954 @default.
- W4293282335 cites W2148540129 @default.
- W4293282335 cites W2151934707 @default.
- W4293282335 cites W2158553737 @default.
- W4293282335 cites W2159652741 @default.
- W4293282335 cites W2233387572 @default.
- W4293282335 cites W2237721705 @default.
- W4293282335 cites W2471404709 @default.
- W4293282335 cites W2520189737 @default.
- W4293282335 cites W2562621663 @default.
- W4293282335 cites W2588195201 @default.
- W4293282335 cites W2606873986 @default.
- W4293282335 cites W2607341885 @default.
- W4293282335 cites W2738287624 @default.
- W4293282335 cites W2787079996 @default.
- W4293282335 cites W2794238585 @default.
- W4293282335 cites W2951618790 @default.
- W4293282335 cites W2962419031 @default.
- W4293282335 cites W2975167992 @default.
- W4293282335 cites W2994082563 @default.
- W4293282335 cites W3027813156 @default.
- W4293282335 cites W3034383545 @default.
- W4293282335 cites W3091885905 @default.
- W4293282335 cites W3126828977 @default.
- W4293282335 cites W3130777840 @default.
- W4293282335 cites W3181374003 @default.
- W4293282335 cites W3184802174 @default.
- W4293282335 cites W3193909442 @default.
- W4293282335 cites W4200244600 @default.
- W4293282335 doi "https://doi.org/10.1093/cercor/bhac287" @default.
- W4293282335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35952337" @default.
- W4293282335 hasPublicationYear "2022" @default.
- W4293282335 type Work @default.
- W4293282335 citedByCount "2" @default.
- W4293282335 countsByYear W42932823352023 @default.
- W4293282335 crossrefType "journal-article" @default.
- W4293282335 hasAuthorship W4293282335A5011951821 @default.
- W4293282335 hasAuthorship W4293282335A5073355185 @default.
- W4293282335 hasConcept C100798922 @default.
- W4293282335 hasConcept C15744967 @default.
- W4293282335 hasConcept C16837860 @default.
- W4293282335 hasConcept C169760540 @default.