FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293313219> ?p ?o ?g. }

• W4293313219 abstract "Abstract Background Dexmedetomidine is widely used in patients with sepsis. However, its effect on septic patients remains controversial. The objective of this study was to summarize all randomized controlled trials (RCTs) examining dexmedetomidine use in sepsis patients. Methods This systematic review and meta-analysis included RCTs comparing dexmedetomidine with other sedatives in adult sepsis patients. We generated pooled relative risks (RRs) and standardized mean differences and performed trial sequential analysis and a cumulative meta-analysis. The primary outcome was mortality, and the secondary outcomes were the length of the intensive care unit stay, duration of mechanical ventilation, number of ventilation-free days, incidence of total adverse event, incidence of delirium, and levels of interleukin 6, tumor necrosis factor alpha, and alanine aminotransferase. Results We included 19 RCTs that enrolled 1929 patients. Compared with other sedatives, dexmedetomidine decreased the all-cause mortality (RR 0.83; 95% confidence interval [CI] [0.69, 0.99]) and inflammatory response (interleukin 6 and tumor necrosis factor alpha levels at 24 h: standardized mean difference (SMD) − 2.15; 95% CI [− 3.25, − 1.05] and SMD − 1.07, 95% CI [− 1.92, − 0.22], respectively). Trial sequential analysis showed that it is not up to required information size. The overall risk adverse events was similar between dexmedetomidine and the other sedatives (RR 1.27, 95% CI [0.69, 2.36]), but dexmedetomidine increased the risk of arrhythmias (RR 1.43, 95% CI [0.59, 3.51]). Length of intensive care unit stay (SMD − 0.22; 95% CI [− 0.85, − 0.41]), duration of mechanical ventilation (SMD 0.12; 95% CI [− 1.10, 1.35]), incidence of delirium (RR 0.98; 95% CI [0.72, 1.33]), and levels of alanine aminotransferase and creatinine at 24 h were not significantly reduced. Conclusions Dexmedetomidine in sepsis patients could significantly reduce mortality compared with benzodiazepines but not with propofol. In addition, dexmedetomidine can significantly decrease inflammatory response in patients with sepsis compared with other sedatives. Dexmedetomidine might lead to an increased incidence of arrhythmias, but its safety profile did not show significant differences in the incidence of total adverse events. Future RCTs are needed to determine the sepsis patient population that would benefit most from dexmedetomidine and its optimal dosing regimen." @default.
• W4293313219 created "2022-08-27" @default.
• W4293313219 creator A5022058360 @default.
• W4293313219 creator A5075283465 @default.
• W4293313219 creator A5077251841 @default.
• W4293313219 creator A5088174174 @default.
• W4293313219 creator A5088988226 @default.
• W4293313219 date "2022-08-27" @default.
• W4293313219 modified "2023-10-14" @default.
• W4293313219 title "Use of dexmedetomidine in patients with sepsis: a systematic review and meta-analysis of randomized-controlled trials" @default.
• W4293313219 cites W1750894135 @default.
• W4293313219 cites W1984552110 @default.
• W4293313219 cites W2031893218 @default.
• W4293313219 cites W2058750158 @default.
• W4293313219 cites W2071637551 @default.
• W4293313219 cites W2087743107 @default.
• W4293313219 cites W2098700447 @default.
• W4293313219 cites W2107328434 @default.
• W4293313219 cites W2123098876 @default.
• W4293313219 cites W2125435699 @default.
• W4293313219 cites W2138928595 @default.
• W4293313219 cites W2142917088 @default.
• W4293313219 cites W2144589352 @default.
• W4293313219 cites W2145116310 @default.
• W4293313219 cites W2164481426 @default.
• W4293313219 cites W2165010366 @default.
• W4293313219 cites W2166190627 @default.
• W4293313219 cites W2280404143 @default.
• W4293313219 cites W2301769892 @default.
• W4293313219 cites W2320350515 @default.
• W4293313219 cites W2578281059 @default.
• W4293313219 cites W2579033526 @default.
• W4293313219 cites W2593363470 @default.
• W4293313219 cites W2600642046 @default.
• W4293313219 cites W2767929859 @default.
• W4293313219 cites W2785304566 @default.
• W4293313219 cites W2811494204 @default.
• W4293313219 cites W2943031144 @default.
• W4293313219 cites W2996380902 @default.
• W4293313219 cites W2998853022 @default.
• W4293313219 cites W3003238214 @default.
• W4293313219 cites W3009610095 @default.
• W4293313219 cites W3012675083 @default.
• W4293313219 cites W3020816774 @default.
• W4293313219 cites W3042981580 @default.
• W4293313219 cites W3092168286 @default.
• W4293313219 cites W3127898334 @default.
• W4293313219 cites W3202964273 @default.
• W4293313219 cites W3205380610 @default.
• W4293313219 cites W3205693479 @default.
• W4293313219 cites W4200213454 @default.
• W4293313219 cites W4200463070 @default.
• W4293313219 cites W4280594928 @default.
• W4293313219 cites W4293242440 @default.
• W4293313219 doi "https://doi.org/10.1186/s13613-022-01052-2" @default.
• W4293313219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36029410" @default.
• W4293313219 hasPublicationYear "2022" @default.
• W4293313219 type Work @default.
• W4293313219 citedByCount "5" @default.
• W4293313219 countsByYear W42933132192022 @default.
• W4293313219 countsByYear W42933132192023 @default.
• W4293313219 crossrefType "journal-article" @default.
• W4293313219 hasAuthorship W4293313219A5022058360 @default.
• W4293313219 hasAuthorship W4293313219A5075283465 @default.
• W4293313219 hasAuthorship W4293313219A5077251841 @default.
• W4293313219 hasAuthorship W4293313219A5088174174 @default.
• W4293313219 hasAuthorship W4293313219A5088988226 @default.
• W4293313219 hasBestOaLocation W42933132191 @default.
• W4293313219 hasConcept C120665830 @default.
• W4293313219 hasConcept C121332964 @default.
• W4293313219 hasConcept C126322002 @default.
• W4293313219 hasConcept C168563851 @default.
• W4293313219 hasConcept C197934379 @default.
• W4293313219 hasConcept C2776376669 @default.
• W4293313219 hasConcept C2776814716 @default.
• W4293313219 hasConcept C2777080012 @default.
• W4293313219 hasConcept C2778384902 @default.
• W4293313219 hasConcept C2779526319 @default.
• W4293313219 hasConcept C2781302539 @default.
• W4293313219 hasConcept C42219234 @default.
• W4293313219 hasConcept C44249647 @default.
• W4293313219 hasConcept C61511704 @default.
• W4293313219 hasConcept C71924100 @default.
• W4293313219 hasConcept C82789193 @default.
• W4293313219 hasConcept C95190672 @default.
• W4293313219 hasConceptScore W4293313219C120665830 @default.
• W4293313219 hasConceptScore W4293313219C121332964 @default.
• W4293313219 hasConceptScore W4293313219C126322002 @default.
• W4293313219 hasConceptScore W4293313219C168563851 @default.
• W4293313219 hasConceptScore W4293313219C197934379 @default.
• W4293313219 hasConceptScore W4293313219C2776376669 @default.
• W4293313219 hasConceptScore W4293313219C2776814716 @default.
• W4293313219 hasConceptScore W4293313219C2777080012 @default.
• W4293313219 hasConceptScore W4293313219C2778384902 @default.
• W4293313219 hasConceptScore W4293313219C2779526319 @default.
• W4293313219 hasConceptScore W4293313219C2781302539 @default.
• W4293313219 hasConceptScore W4293313219C42219234 @default.
• W4293313219 hasConceptScore W4293313219C44249647 @default.
• W4293313219 hasConceptScore W4293313219C61511704 @default.
• W4293313219 hasConceptScore W4293313219C71924100 @default.

• next