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- W4293313285 abstract "Abstract As the aromatic tryptophan (Trp) side chain plays a pivotal role in influencing the structure and function of peptides and proteins, it has become an attractive target for the late‐stage modification of these important biomolecules. Herein, we report an electrochemical approach for late‐stage functionalization of peptides containing a Trp side chain through manganese‐catalyzed tandem radical azidation/heterocyclization. This electrochemical oxidative strategy provides access to azide‐substituted tetrazolo[1,5‐ a ]indole‐containing peptides with broad functional group tolerance, high site selectivity, and good yields of products (up to 87 %) under mild buffer conditions. Moreover, the modified Trp‐containing peptides bearing an azide functionality are promising building blocks, paving the way for the construction of various derivatives, such as “click” chemistry products." @default.
- W4293313285 created "2022-08-27" @default.
- W4293313285 creator A5016827324 @default.
- W4293313285 creator A5025011429 @default.
- W4293313285 creator A5040358599 @default.
- W4293313285 creator A5059349483 @default.
- W4293313285 creator A5082748289 @default.
- W4293313285 date "2022-09-08" @default.
- W4293313285 modified "2023-09-25" @default.
- W4293313285 title "Tandem Electrochemical Oxidative Azidation/Heterocyclization of Tryptophan‐Containing Peptides under Buffer Conditions" @default.
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