Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293315599> ?p ?o ?g. }
- W4293315599 abstract "SUMMARY Thermogenesis by uncoupling protein 1 (UCP1) is one of the primary mechanisms by which brown adipose tissue (BAT) increases energy expenditure. UCP1 resides in the inner mitochondrial membrane (IMM), where it dissipates membrane potential independent of ATP synthase. Here we provide evidence that mitochondrial phosphatidylethanolamine (PE) directly regulates UCP1-dependent proton conductance across IMM to modulate thermogenesis. Mitochondrial lipidomic analyses revealed PE as a signature molecule whose abundance bidirectionally responds to changes in thermogenic burden. Reduction in mitochondrial PE by deletion of phosphatidylserine decarboxylase (PSD) made mice cold intolerant and insensitive to β3 adrenergic receptor agonist-induced increase in whole-body oxygen consumption. High-resolution respirometry and fluorometry of BAT mitochondria showed that loss of mitochondrial PE specifically lowers UCP1-dependent respiration without compromising electron transfer efficiency or ATP synthesis. These findings were confirmed by a reduction in UCP1 proton current in PSD-deficient mitoplasts. Thus, PE performs a previously unknown role as a temperature-responsive rheostat that regulates UCP1-dependent thermogenesis." @default.
- W4293315599 created "2022-08-27" @default.
- W4293315599 creator A5008491511 @default.
- W4293315599 creator A5009379188 @default.
- W4293315599 creator A5009445429 @default.
- W4293315599 creator A5013687539 @default.
- W4293315599 creator A5021822368 @default.
- W4293315599 creator A5025222948 @default.
- W4293315599 creator A5037340120 @default.
- W4293315599 creator A5047406643 @default.
- W4293315599 creator A5047779719 @default.
- W4293315599 creator A5051699553 @default.
- W4293315599 creator A5057351324 @default.
- W4293315599 creator A5058172951 @default.
- W4293315599 creator A5063404794 @default.
- W4293315599 creator A5063526218 @default.
- W4293315599 creator A5066898531 @default.
- W4293315599 creator A5067372081 @default.
- W4293315599 creator A5071796060 @default.
- W4293315599 creator A5084072622 @default.
- W4293315599 date "2022-08-26" @default.
- W4293315599 modified "2023-10-16" @default.
- W4293315599 title "Mitochondrial Phosphatidylethanolamine Directly Regulates UCP1 to Promote Brown Adipose Thermogenesis" @default.
- W4293315599 cites W1761885863 @default.
- W4293315599 cites W1800612837 @default.
- W4293315599 cites W1843473569 @default.
- W4293315599 cites W1905697185 @default.
- W4293315599 cites W1974145389 @default.
- W4293315599 cites W1990675802 @default.
- W4293315599 cites W1990826643 @default.
- W4293315599 cites W1993103335 @default.
- W4293315599 cites W1998391556 @default.
- W4293315599 cites W2012460974 @default.
- W4293315599 cites W2020435369 @default.
- W4293315599 cites W2028843821 @default.
- W4293315599 cites W2032555072 @default.
- W4293315599 cites W2038112791 @default.
- W4293315599 cites W2042879438 @default.
- W4293315599 cites W2047306805 @default.
- W4293315599 cites W2048629134 @default.
- W4293315599 cites W2050189794 @default.
- W4293315599 cites W2051794578 @default.
- W4293315599 cites W2053859130 @default.
- W4293315599 cites W2070332785 @default.
- W4293315599 cites W2073225838 @default.
- W4293315599 cites W2081492061 @default.
- W4293315599 cites W2083602312 @default.
- W4293315599 cites W2085754322 @default.
- W4293315599 cites W2092162941 @default.
- W4293315599 cites W2119441851 @default.
- W4293315599 cites W2122762775 @default.
- W4293315599 cites W2129349289 @default.
- W4293315599 cites W2134886125 @default.
- W4293315599 cites W2167376541 @default.
- W4293315599 cites W2176909443 @default.
- W4293315599 cites W2269880005 @default.
- W4293315599 cites W2274445210 @default.
- W4293315599 cites W2320935315 @default.
- W4293315599 cites W2464639360 @default.
- W4293315599 cites W2467095003 @default.
- W4293315599 cites W2550433123 @default.
- W4293315599 cites W2588062112 @default.
- W4293315599 cites W2605431828 @default.
- W4293315599 cites W2607117102 @default.
- W4293315599 cites W2768973912 @default.
- W4293315599 cites W2798127297 @default.
- W4293315599 cites W2806975221 @default.
- W4293315599 cites W2884894132 @default.
- W4293315599 cites W2902950556 @default.
- W4293315599 cites W2939134179 @default.
- W4293315599 cites W2953381699 @default.
- W4293315599 cites W2957566337 @default.
- W4293315599 cites W2973163219 @default.
- W4293315599 cites W2988722164 @default.
- W4293315599 cites W3002350800 @default.
- W4293315599 cites W3007127123 @default.
- W4293315599 cites W3025317614 @default.
- W4293315599 cites W3138677872 @default.
- W4293315599 cites W3217398453 @default.
- W4293315599 cites W4214703927 @default.
- W4293315599 cites W4280631138 @default.
- W4293315599 doi "https://doi.org/10.1101/2022.08.26.505474" @default.
- W4293315599 hasPublicationYear "2022" @default.
- W4293315599 type Work @default.
- W4293315599 citedByCount "0" @default.
- W4293315599 crossrefType "posted-content" @default.
- W4293315599 hasAuthorship W4293315599A5008491511 @default.
- W4293315599 hasAuthorship W4293315599A5009379188 @default.
- W4293315599 hasAuthorship W4293315599A5009445429 @default.
- W4293315599 hasAuthorship W4293315599A5013687539 @default.
- W4293315599 hasAuthorship W4293315599A5021822368 @default.
- W4293315599 hasAuthorship W4293315599A5025222948 @default.
- W4293315599 hasAuthorship W4293315599A5037340120 @default.
- W4293315599 hasAuthorship W4293315599A5047406643 @default.
- W4293315599 hasAuthorship W4293315599A5047779719 @default.
- W4293315599 hasAuthorship W4293315599A5051699553 @default.
- W4293315599 hasAuthorship W4293315599A5057351324 @default.
- W4293315599 hasAuthorship W4293315599A5058172951 @default.
- W4293315599 hasAuthorship W4293315599A5063404794 @default.
- W4293315599 hasAuthorship W4293315599A5063526218 @default.