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- W4293318087 abstract "Central nervous system (CNS) metastases are a common manifestation of malignant melanoma, with a median overall survival of as little as 4.7 months based on a study of patients diagnosed between 1986 and 2004 prior to the era of effective systemic therapy. Yet most of the clinical trials exclude patients with intra-cranial metastases. CNS involvement often causes neurological deficits and functional impairment. Localised therapies, such as surgical excision and stereotactic radiotherapy are applicable to only a minority of patients. There are evidences of clinical benefits for immunotherapy than best supportive care and when given alongside radiotherapy provides a better overall survival than radiotherapy alone. This chapter evaluates the efficacy and toxicity of these treatments against advanced melanoma patients with brain metastases." @default.
- W4293318087 created "2022-08-27" @default.
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- W4293318087 date "2023-04-05" @default.
- W4293318087 modified "2023-09-30" @default.
- W4293318087 title "Intracranial Metastatic Melanoma" @default.
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- W4293318087 doi "https://doi.org/10.5772/intechopen.106667" @default.
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