Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293330204> ?p ?o ?g. }
- W4293330204 endingPage "27" @default.
- W4293330204 startingPage "14" @default.
- W4293330204 abstract "Pancreatic cancer (PC) has exceptionally high mortality due to ineffective treatment strategies. Immunotherapy, which mobilizes the immune system to fight against cancer, has been proven successful in multiple cancers; however, its application in PC has met with limited success. In this review, we articulated that the pancreatic tumor microenvironment is immuno-suppressive with extensive infiltration by M2-macrophages and myeloid-derived suppressive cells but low numbers of cytotoxic T-cells. In addition, low mutational load and poor antigen processing, presentation, and recognition contribute to the limited response to immunotherapy in PC. Immune checkpoints, the critical targets for immunotherapy, have high expression in PC and stromal cells, regulated by tumor microenvironmental milieu (cytokine and metabolites) and cell-intrinsic mechanisms (epigenetic regulation, oncogenic signaling, and post-translational modifications). Combining immunotherapy with modulators of the tumor microenvironment may facilitate the development of novel therapeutic regimens to manage PC." @default.
- W4293330204 created "2022-08-27" @default.
- W4293330204 creator A5017358599 @default.
- W4293330204 creator A5065758067 @default.
- W4293330204 creator A5082416849 @default.
- W4293330204 creator A5085256777 @default.
- W4293330204 creator A5086505077 @default.
- W4293330204 creator A5086534465 @default.
- W4293330204 creator A5090154787 @default.
- W4293330204 date "2022-11-01" @default.
- W4293330204 modified "2023-10-16" @default.
- W4293330204 title "Immune checkpoint blockade in pancreatic cancer: Trudging through the immune desert" @default.
- W4293330204 cites W1841418760 @default.
- W4293330204 cites W1957985734 @default.
- W4293330204 cites W1969705513 @default.
- W4293330204 cites W1972338421 @default.
- W4293330204 cites W1977144608 @default.
- W4293330204 cites W1986497348 @default.
- W4293330204 cites W1992995822 @default.
- W4293330204 cites W1993993797 @default.
- W4293330204 cites W1996912024 @default.
- W4293330204 cites W1997944395 @default.
- W4293330204 cites W1999195849 @default.
- W4293330204 cites W1999240526 @default.
- W4293330204 cites W2001358928 @default.
- W4293330204 cites W2004150448 @default.
- W4293330204 cites W2004312434 @default.
- W4293330204 cites W2016789384 @default.
- W4293330204 cites W2017201358 @default.
- W4293330204 cites W2017396583 @default.
- W4293330204 cites W2019022043 @default.
- W4293330204 cites W2030612376 @default.
- W4293330204 cites W2035566116 @default.
- W4293330204 cites W2040179301 @default.
- W4293330204 cites W2040775084 @default.
- W4293330204 cites W2043991982 @default.
- W4293330204 cites W2044433401 @default.
- W4293330204 cites W2046768931 @default.
- W4293330204 cites W2046972425 @default.
- W4293330204 cites W2055873373 @default.
- W4293330204 cites W2057977955 @default.
- W4293330204 cites W2060469376 @default.
- W4293330204 cites W2063551078 @default.
- W4293330204 cites W2064442490 @default.
- W4293330204 cites W2066135299 @default.
- W4293330204 cites W2069169522 @default.
- W4293330204 cites W2069698188 @default.
- W4293330204 cites W2070631889 @default.
- W4293330204 cites W2079999658 @default.
- W4293330204 cites W2080798807 @default.
- W4293330204 cites W2081990599 @default.
- W4293330204 cites W2085605492 @default.
- W4293330204 cites W2086834665 @default.
- W4293330204 cites W2087959519 @default.
- W4293330204 cites W2088110734 @default.
- W4293330204 cites W2097801564 @default.
- W4293330204 cites W2097855813 @default.
- W4293330204 cites W2100039832 @default.
- W4293330204 cites W2100519108 @default.
- W4293330204 cites W2112400160 @default.
- W4293330204 cites W2112853593 @default.
- W4293330204 cites W2115536507 @default.
- W4293330204 cites W2116495352 @default.
- W4293330204 cites W2117552772 @default.
- W4293330204 cites W2121273824 @default.
- W4293330204 cites W2121626779 @default.
- W4293330204 cites W2122730216 @default.
- W4293330204 cites W2123149440 @default.
- W4293330204 cites W2123918574 @default.
- W4293330204 cites W2128957395 @default.
- W4293330204 cites W2130594874 @default.
- W4293330204 cites W2130822830 @default.
- W4293330204 cites W2132280604 @default.
- W4293330204 cites W2146791037 @default.
- W4293330204 cites W2148226248 @default.
- W4293330204 cites W2148901520 @default.
- W4293330204 cites W2149360266 @default.
- W4293330204 cites W2149748445 @default.
- W4293330204 cites W2152181022 @default.
- W4293330204 cites W2155464214 @default.
- W4293330204 cites W2156411980 @default.
- W4293330204 cites W2173447488 @default.
- W4293330204 cites W2209812019 @default.
- W4293330204 cites W2291579888 @default.
- W4293330204 cites W2317673718 @default.
- W4293330204 cites W2318825508 @default.
- W4293330204 cites W2364821648 @default.
- W4293330204 cites W2403400382 @default.
- W4293330204 cites W2417769997 @default.
- W4293330204 cites W2418018584 @default.
- W4293330204 cites W2461513545 @default.
- W4293330204 cites W2469223980 @default.
- W4293330204 cites W2510426677 @default.
- W4293330204 cites W2514792180 @default.
- W4293330204 cites W2516619560 @default.
- W4293330204 cites W2530185890 @default.
- W4293330204 cites W2537220355 @default.
- W4293330204 cites W2538063110 @default.