FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293368478> ?p ?o ?g. }

• W4293368478 endingPage "1173" @default.
• W4293368478 startingPage "1166" @default.
• W4293368478 abstract "Abstract Background Implementation of point‐of‐care tests is recommended to provide tailored substitution during cardiac surgery. The measurement and substitution of fibrinogen have gained particular interest since it is the first coagulation factor to become depleted during cardiac surgery. However, the prognostic ability of thromboelastography (TEG) 6s has not been evaluated in pediatric patients. The aim of the present study was to describe patient characteristics of infants receiving fibrinogen substitution during cardiac surgery and evaluate the prognostic ability of TEG6s after weaning off cardiopulmonary bypass (CPB). Methods Infants undergoing congenital cardiac surgery with CPB were retrospectively included ( n = 279) between January 2017 to July 2019. Patient and perioperative data were collected on the day of surgery until 6:00 AM the next morning. Hemostatic capacity was assessed with TEG6s. The efficacy of TEG‐functional fibrinogen‐maximal amplitude (TEG‐FF‐MA) measurements for the prediction of intraoperative bleeding, and thereby cryoprecipitate need, was evaluated by a sensitivity and specificity analysis. Results Among 174 children with TEG‐FF‐MA data, 147 (84%) received cryoprecipitate intraoperatively. Cryoprecipitate administration was associated with younger age 66 (10–132) versus 98 (45–204) days ( p = .044), higher RACHS‐1 classification, and intraoperative bleeding 21 (11–47) versus 5 (3–13) ml/kg ( p < .001, mean difference 29 ml/kg [CI: 8–50]). Median TEG‐FF‐MA values were lower in transfused children 7.6 (5.3–11.0) versus 10.5 (7.3–13.4) mm ( p = .004, mean difference − 2.4 mm [CI: −4.1 to − 0.73]). The volume of cryoprecipitate was associated with bypass time, TEG‐FF‐MA values, and in particular intraoperative bleeding volumes. A TEG‐FF‐MA threshold of 10.0 mm, resulted in sensitivity: 74%, specificity: 56%, positive predictive value: 80%, and a negative predictive value of 47% for the prediction of intraoperative bleeding (>10 ml/kg) and consequently a need of cryoprecipitate transfusion. Conclusion Fibrinogen substitution in infants was associated with younger age and higher RACHS‐1 category. The prognostic value of TEG6s was evaluated, and cryoprecipitate transfusion was related to TEG‐FF‐MA values, but also CPB‐time, surgical complexity, and in particular excessive intraoperative bleeding. A clear‐cut threshold for TEG‐FF‐MA is difficult to establish in infants undertaken congenital heart surgery." @default.
• W4293368478 created "2022-08-28" @default.
• W4293368478 creator A5033626510 @default.
• W4293368478 creator A5044148771 @default.
• W4293368478 creator A5047829351 @default.
• W4293368478 creator A5053657802 @default.
• W4293368478 creator A5075168916 @default.
• W4293368478 creator A5075814237 @default.
• W4293368478 date "2022-09-11" @default.
• W4293368478 modified "2023-10-18" @default.
• W4293368478 title "Evaluation of <scp>Thromboelastography 6s</scp> prognostication of fibrinogen supplementation in pediatric cardiac surgery" @default.
• W4293368478 cites W1481535927 @default.
• W4293368478 cites W1916895789 @default.
• W4293368478 cites W1973398496 @default.
• W4293368478 cites W1994702025 @default.
• W4293368478 cites W2010019786 @default.
• W4293368478 cites W2019560744 @default.
• W4293368478 cites W2028259055 @default.
• W4293368478 cites W2130057880 @default.
• W4293368478 cites W2150519320 @default.
• W4293368478 cites W2163874957 @default.
• W4293368478 cites W2320972450 @default.
• W4293368478 cites W2395398120 @default.
• W4293368478 cites W2560210351 @default.
• W4293368478 cites W2623832617 @default.
• W4293368478 cites W2760976407 @default.
• W4293368478 cites W2779019061 @default.
• W4293368478 cites W2886888258 @default.
• W4293368478 cites W2904568059 @default.
• W4293368478 cites W2906628075 @default.
• W4293368478 cites W2921652255 @default.
• W4293368478 cites W2950544385 @default.
• W4293368478 cites W2953578861 @default.
• W4293368478 cites W2955022681 @default.
• W4293368478 cites W3091369783 @default.
• W4293368478 cites W3093669150 @default.
• W4293368478 cites W3100025786 @default.
• W4293368478 cites W4293368478 @default.
• W4293368478 cites W809013994 @default.
• W4293368478 doi "https://doi.org/10.1111/aas.14144" @default.
• W4293368478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36054262" @default.
• W4293368478 hasPublicationYear "2022" @default.
• W4293368478 type Work @default.
• W4293368478 citedByCount "2" @default.
• W4293368478 countsByYear W42933684782022 @default.
• W4293368478 crossrefType "journal-article" @default.
• W4293368478 hasAuthorship W4293368478A5033626510 @default.
• W4293368478 hasAuthorship W4293368478A5044148771 @default.
• W4293368478 hasAuthorship W4293368478A5047829351 @default.
• W4293368478 hasAuthorship W4293368478A5053657802 @default.
• W4293368478 hasAuthorship W4293368478A5075168916 @default.
• W4293368478 hasAuthorship W4293368478A5075814237 @default.
• W4293368478 hasBestOaLocation W42933684781 @default.
• W4293368478 hasConcept C126322002 @default.
• W4293368478 hasConcept C141071460 @default.
• W4293368478 hasConcept C2777664302 @default.
• W4293368478 hasConcept C2778258694 @default.
• W4293368478 hasConcept C2778382381 @default.
• W4293368478 hasConcept C2778789114 @default.
• W4293368478 hasConcept C2778881276 @default.
• W4293368478 hasConcept C2779036427 @default.
• W4293368478 hasConcept C31174226 @default.
• W4293368478 hasConcept C42219234 @default.
• W4293368478 hasConcept C71924100 @default.
• W4293368478 hasConceptScore W4293368478C126322002 @default.
• W4293368478 hasConceptScore W4293368478C141071460 @default.
• W4293368478 hasConceptScore W4293368478C2777664302 @default.
• W4293368478 hasConceptScore W4293368478C2778258694 @default.
• W4293368478 hasConceptScore W4293368478C2778382381 @default.
• W4293368478 hasConceptScore W4293368478C2778789114 @default.
• W4293368478 hasConceptScore W4293368478C2778881276 @default.
• W4293368478 hasConceptScore W4293368478C2779036427 @default.
• W4293368478 hasConceptScore W4293368478C31174226 @default.
• W4293368478 hasConceptScore W4293368478C42219234 @default.
• W4293368478 hasConceptScore W4293368478C71924100 @default.
• W4293368478 hasIssue "10" @default.
• W4293368478 hasLocation W42933684781 @default.
• W4293368478 hasLocation W42933684782 @default.
• W4293368478 hasLocation W42933684783 @default.
• W4293368478 hasLocation W42933684784 @default.
• W4293368478 hasLocation W42933684785 @default.
• W4293368478 hasOpenAccess W4293368478 @default.
• W4293368478 hasPrimaryLocation W42933684781 @default.
• W4293368478 hasRelatedWork W1837030616 @default.
• W4293368478 hasRelatedWork W2134378113 @default.
• W4293368478 hasRelatedWork W2323995183 @default.
• W4293368478 hasRelatedWork W3037323303 @default.
• W4293368478 hasRelatedWork W4283660947 @default.
• W4293368478 hasRelatedWork W4293368478 @default.
• W4293368478 hasRelatedWork W4311450203 @default.
• W4293368478 hasRelatedWork W4381598479 @default.
• W4293368478 hasRelatedWork W809013994 @default.
• W4293368478 hasRelatedWork W2521232904 @default.
• W4293368478 hasVolume "66" @default.
• W4293368478 isParatext "false" @default.
• W4293368478 isRetracted "false" @default.
• W4293368478 workType "article" @default.