FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293375265> ?p ?o ?g. }

• W4293375265 endingPage "315" @default.
• W4293375265 startingPage "311" @default.
• W4293375265 abstract "Sodium glucose co-transporter (SGLT) 2 inhibitors are oral anti-diabetic drugs with proven kidney protective effects. Renal protective effects in non-diabetic individuals have also been shown in recent studies. The aim of this study was to determine the renal protective effects of dapagliflozin by evaluating the oxidative stress markers in the kidney tissue and demonstrating it in renal histological sections in an iron-overloaded rat model.A total of 24 Wistar Albino rats were separated into 3 groups of 8 rats. Iron sucrose (60 ​mg/kg/day) was administered intraperitoneally to the first group (Group Fe) (n ​= ​8), iron sucrose and dapagliflozin (0.1 ​mg/kg/day) to the second group (Group Fe ​+ ​D) (n ​= ​8) and intraperitoneal saline as placebo to the control group (Group C) (n ​= ​8) for 4 weeks. The glomerular changes were semi-quantitatively scored with Oxford Classification. Oxidative stress was analyzed from the tissue fluorescent oxidation product (FLOP), malondialdehyde (MDA) and total sulfhydryl (T-SH) levels.Dapagliflozin prevented glomerular and mesangial damage of iron overload in the non-diabetic rat model. MDA levels were significantly higher in Group Fe compared to the Group C, and there was no significant difference between the Fe ​+ ​D group and Group C. T-SH levels were preserved in the Fe ​+ ​D group and were significantly higher than in the Fe group.The results of this study showed that dapagliflozin helped preserve the glomerular and mesangial structure histologically and reduced oxidative stress markers in a non-diabetic iron overload rat model." @default.
• W4293375265 created "2022-08-28" @default.
• W4293375265 creator A5015695654 @default.
• W4293375265 creator A5025599967 @default.
• W4293375265 creator A5038492883 @default.
• W4293375265 creator A5049418775 @default.
• W4293375265 creator A5063135868 @default.
• W4293375265 creator A5069522246 @default.
• W4293375265 date "2022-09-01" @default.
• W4293375265 modified "2023-09-29" @default.
• W4293375265 title "Renoprotective effects of dapagliflozin in an iron overload non-diabetic rat model" @default.
• W4293375265 cites W1707044792 @default.
• W4293375265 cites W1971727064 @default.
• W4293375265 cites W2002253678 @default.
• W4293375265 cites W2011683287 @default.
• W4293375265 cites W2023244494 @default.
• W4293375265 cites W2033282119 @default.
• W4293375265 cites W2063576996 @default.
• W4293375265 cites W2066615574 @default.
• W4293375265 cites W2106705131 @default.
• W4293375265 cites W2148182857 @default.
• W4293375265 cites W2170941566 @default.
• W4293375265 cites W2395942772 @default.
• W4293375265 cites W2424539745 @default.
• W4293375265 cites W2602196428 @default.
• W4293375265 cites W2626446274 @default.
• W4293375265 cites W2769932926 @default.
• W4293375265 cites W2782341620 @default.
• W4293375265 cites W2795816442 @default.
• W4293375265 cites W2884202881 @default.
• W4293375265 cites W2887628755 @default.
• W4293375265 cites W2900665718 @default.
• W4293375265 cites W2900940745 @default.
• W4293375265 cites W2919368874 @default.
• W4293375265 cites W2944523362 @default.
• W4293375265 cites W2948520814 @default.
• W4293375265 cites W2955781565 @default.
• W4293375265 cites W2992890959 @default.
• W4293375265 cites W3024144838 @default.
• W4293375265 cites W3088173406 @default.
• W4293375265 doi "https://doi.org/10.1016/j.advms.2022.08.001" @default.
• W4293375265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36037575" @default.
• W4293375265 hasPublicationYear "2022" @default.
• W4293375265 type Work @default.
• W4293375265 citedByCount "0" @default.
• W4293375265 crossrefType "journal-article" @default.
• W4293375265 hasAuthorship W4293375265A5015695654 @default.
• W4293375265 hasAuthorship W4293375265A5025599967 @default.
• W4293375265 hasAuthorship W4293375265A5038492883 @default.
• W4293375265 hasAuthorship W4293375265A5049418775 @default.
• W4293375265 hasAuthorship W4293375265A5063135868 @default.
• W4293375265 hasAuthorship W4293375265A5069522246 @default.
• W4293375265 hasConcept C126322002 @default.
• W4293375265 hasConcept C134018914 @default.
• W4293375265 hasConcept C142724271 @default.
• W4293375265 hasConcept C204787440 @default.
• W4293375265 hasConcept C27081682 @default.
• W4293375265 hasConcept C2776151105 @default.
• W4293375265 hasConcept C2776974161 @default.
• W4293375265 hasConcept C2777180221 @default.
• W4293375265 hasConcept C2777417653 @default.
• W4293375265 hasConcept C2777422806 @default.
• W4293375265 hasConcept C2778248108 @default.
• W4293375265 hasConcept C2778401633 @default.
• W4293375265 hasConcept C2780091579 @default.
• W4293375265 hasConcept C2780306776 @default.
• W4293375265 hasConcept C3020614022 @default.
• W4293375265 hasConcept C555293320 @default.
• W4293375265 hasConcept C71924100 @default.
• W4293375265 hasConceptScore W4293375265C126322002 @default.
• W4293375265 hasConceptScore W4293375265C134018914 @default.
• W4293375265 hasConceptScore W4293375265C142724271 @default.
• W4293375265 hasConceptScore W4293375265C204787440 @default.
• W4293375265 hasConceptScore W4293375265C27081682 @default.
• W4293375265 hasConceptScore W4293375265C2776151105 @default.
• W4293375265 hasConceptScore W4293375265C2776974161 @default.
• W4293375265 hasConceptScore W4293375265C2777180221 @default.
• W4293375265 hasConceptScore W4293375265C2777417653 @default.
• W4293375265 hasConceptScore W4293375265C2777422806 @default.
• W4293375265 hasConceptScore W4293375265C2778248108 @default.
• W4293375265 hasConceptScore W4293375265C2778401633 @default.
• W4293375265 hasConceptScore W4293375265C2780091579 @default.
• W4293375265 hasConceptScore W4293375265C2780306776 @default.
• W4293375265 hasConceptScore W4293375265C3020614022 @default.
• W4293375265 hasConceptScore W4293375265C555293320 @default.
• W4293375265 hasConceptScore W4293375265C71924100 @default.
• W4293375265 hasIssue "2" @default.
• W4293375265 hasLocation W42933752651 @default.
• W4293375265 hasLocation W42933752652 @default.
• W4293375265 hasOpenAccess W4293375265 @default.
• W4293375265 hasPrimaryLocation W42933752651 @default.
• W4293375265 hasRelatedWork W2020959757 @default.
• W4293375265 hasRelatedWork W2042033030 @default.
• W4293375265 hasRelatedWork W2044943066 @default.
• W4293375265 hasRelatedWork W2070511355 @default.
• W4293375265 hasRelatedWork W2082456910 @default.
• W4293375265 hasRelatedWork W2098742882 @default.
• W4293375265 hasRelatedWork W2127085070 @default.

• next