FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293397246> ?p ?o ?g. }

• W4293397246 endingPage "19" @default.
• W4293397246 startingPage "1" @default.
• W4293397246 abstract "Hepatocellular carcinoma (HCC) is a worldwide malignant cancer with high incidence and mortality. Considering the high heterogeneity of HCC, clarifying molecular characteristics associated with HCC development could help improve patients' outcomes. Pyroptosis is a novel form of cell death and is noted to be implicated in HCC pathogenesis whereas its molecular feature in HCC is unclear. Thus, we intended to clarify the molecular characteristic as well as the clinical significance of pyroptosis for HCC. A systematic bioinformatics analysis was conducted among 40 pyroptosis-related genes based on The Cancer Genome Atlas, the International Cancer Genome Consortium, and the Gene Expression Omnibus databases. A total of 12 HCC-associated pyroptosis-related genes (HPRGs) were identified to be overexpressed in HCC tissues and significantly connected to patients' poor survival. Through consensus clustering based on the HPRGs' expression, we found patients could be stratified into two distinctive pyroptosis subtypes, PyLow and PyHigh. The PyHigh group owned a notable lower survival rate and a higher high-grade proportion compared with the PyLow subtype. Besides, patients' sensitivities to chemotherapeutic drugs also presented distinctive differences between the two subtypes. Indicated by pathway enrichment analysis and immune characteristic difference analysis, the distinctions between the pyroptosis subtypes may be related to tumor immunity. Further, a five-gene risk model composed of BAK1, CHMP4A, CHMP4B, DHX9, and GSDME was established. Subsequent analyses demonstrated that the model could credibly classify patients as low or high risk and was an independent prognostic indicator for HCC. Abnormal expressions of the five genes were validated by biological experiments and new bioinformatics analysis. In conclusion, this study recognized and verified two heterogeneous pyroptosis subtypes and a predictable prognosis model for HCC. Our work may help facilitate the clinical management and treatment of HCC and understand the functions of pyroptosis in oncology." @default.
• W4293397246 created "2022-08-28" @default.
• W4293397246 creator A5006458345 @default.
• W4293397246 creator A5017652215 @default.
• W4293397246 creator A5027484539 @default.
• W4293397246 creator A5028105581 @default.
• W4293397246 creator A5031841032 @default.
• W4293397246 creator A5036698982 @default.
• W4293397246 creator A5051782587 @default.
• W4293397246 creator A5065297872 @default.
• W4293397246 creator A5065339043 @default.
• W4293397246 creator A5069703039 @default.
• W4293397246 creator A5081065929 @default.
• W4293397246 date "2022-08-28" @default.
• W4293397246 modified "2023-10-15" @default.
• W4293397246 title "Identification and Validation of Two Heterogeneous Molecular Subtypes and a Prognosis Predictive Model for Hepatocellular Carcinoma Based on Pyroptosis" @default.
• W4293397246 cites W1587712169 @default.
• W4293397246 cites W1966116114 @default.
• W4293397246 cites W2010457001 @default.
• W4293397246 cites W2012034410 @default.
• W4293397246 cites W2035618305 @default.
• W4293397246 cites W2057529515 @default.
• W4293397246 cites W2075294566 @default.
• W4293397246 cites W2086070404 @default.
• W4293397246 cites W2097360283 @default.
• W4293397246 cites W2110065044 @default.
• W4293397246 cites W2110320497 @default.
• W4293397246 cites W2114338107 @default.
• W4293397246 cites W2115462905 @default.
• W4293397246 cites W2117692326 @default.
• W4293397246 cites W2157076315 @default.
• W4293397246 cites W2159707944 @default.
• W4293397246 cites W2165638318 @default.
• W4293397246 cites W2431987552 @default.
• W4293397246 cites W2525429999 @default.
• W4293397246 cites W2608687752 @default.
• W4293397246 cites W2610420640 @default.
• W4293397246 cites W2611864304 @default.
• W4293397246 cites W2740869100 @default.
• W4293397246 cites W2749613778 @default.
• W4293397246 cites W2792468812 @default.
• W4293397246 cites W2885385214 @default.
• W4293397246 cites W2889646458 @default.
• W4293397246 cites W2889924499 @default.
• W4293397246 cites W2898314774 @default.
• W4293397246 cites W2923527365 @default.
• W4293397246 cites W2937441321 @default.
• W4293397246 cites W2971848123 @default.
• W4293397246 cites W2972758365 @default.
• W4293397246 cites W2989083977 @default.
• W4293397246 cites W2990323558 @default.
• W4293397246 cites W2990621560 @default.
• W4293397246 cites W2999534343 @default.
• W4293397246 cites W3002915202 @default.
• W4293397246 cites W3030012850 @default.
• W4293397246 cites W3034448267 @default.
• W4293397246 cites W3039436229 @default.
• W4293397246 cites W3122332729 @default.
• W4293397246 cites W3142080073 @default.
• W4293397246 cites W3144571741 @default.
• W4293397246 cites W3171550932 @default.
• W4293397246 cites W3202013745 @default.
• W4293397246 cites W3202814778 @default.
• W4293397246 cites W3205912411 @default.
• W4293397246 cites W3206666468 @default.
• W4293397246 cites W3211639459 @default.
• W4293397246 cites W3211829118 @default.
• W4293397246 cites W3212348071 @default.
• W4293397246 cites W4200609800 @default.
• W4293397246 cites W4205486129 @default.
• W4293397246 cites W4205839370 @default.
• W4293397246 cites W4205952785 @default.
• W4293397246 cites W4207083393 @default.
• W4293397246 cites W4210530293 @default.
• W4293397246 cites W4213058756 @default.
• W4293397246 cites W4237441880 @default.
• W4293397246 cites W4283714400 @default.
• W4293397246 cites W4294541781 @default.
• W4293397246 doi "https://doi.org/10.1155/2022/8346816" @default.
• W4293397246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36071875" @default.
• W4293397246 hasPublicationYear "2022" @default.
• W4293397246 type Work @default.
• W4293397246 citedByCount "5" @default.
• W4293397246 countsByYear W42933972462022 @default.
• W4293397246 countsByYear W42933972462023 @default.
• W4293397246 crossrefType "journal-article" @default.
• W4293397246 hasAuthorship W4293397246A5006458345 @default.
• W4293397246 hasAuthorship W4293397246A5017652215 @default.
• W4293397246 hasAuthorship W4293397246A5027484539 @default.
• W4293397246 hasAuthorship W4293397246A5028105581 @default.
• W4293397246 hasAuthorship W4293397246A5031841032 @default.
• W4293397246 hasAuthorship W4293397246A5036698982 @default.
• W4293397246 hasAuthorship W4293397246A5051782587 @default.
• W4293397246 hasAuthorship W4293397246A5065297872 @default.
• W4293397246 hasAuthorship W4293397246A5065339043 @default.
• W4293397246 hasAuthorship W4293397246A5069703039 @default.
• W4293397246 hasAuthorship W4293397246A5081065929 @default.
• W4293397246 hasBestOaLocation W42933972461 @default.

• next