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- W4293404329 abstract "Myeloid leukemia associated with Down syndrome (ML-DS) has a unique molecular landscape that differs from other subtypes of acute myeloid leukemia. ML-DS is often preceded by a myeloproliferative neoplastic condition called transient abnormal myelopoiesis (TAM) that disrupts megakaryocytic and erythroid differentiation. Over the last two decades, many genetic and epigenetic changes in TAM and ML-DS have been elucidated. These include overexpression of molecules and micro-RNAs located on chromosome 21, GATA1 mutations, and a range of other somatic mutations and chromosomal alterations. In this review, we summarize molecular changes reported in TAM and ML-DS and provide a comprehensive discussion of these findings. Recent advances in the development of CRISPR/Cas9-modified induced pluripotent stem cell-based disease models are also highlighted. However, despite significant progress in this area, we still do not fully understand the pathogenesis of ML-DS, and there are no targeted therapies. Initial diagnosis of ML-DS has a favorable prognosis, but refractory and relapsed disease can be difficult to treat; therapeutic options are limited in Down syndrome children by their stronger sensitivity to the toxic effects of chemotherapy. Because of the rarity of TAM and ML-DS, large-scale multi-center studies would be helpful to advance molecular characterization of these diseases at different stages of development and progression." @default.
- W4293404329 created "2022-08-28" @default.
- W4293404329 creator A5029413117 @default.
- W4293404329 creator A5076969799 @default.
- W4293404329 date "2022-08-10" @default.
- W4293404329 modified "2023-10-14" @default.
- W4293404329 title "Advances in molecular characterization of myeloid proliferations associated with Down syndrome" @default.
- W4293404329 cites W1669374546 @default.
- W4293404329 cites W1914798032 @default.
- W4293404329 cites W1976386009 @default.
- W4293404329 cites W1977659503 @default.
- W4293404329 cites W1979376633 @default.
- W4293404329 cites W1984714342 @default.
- W4293404329 cites W1984714707 @default.
- W4293404329 cites W1985636758 @default.
- W4293404329 cites W1989374543 @default.
- W4293404329 cites W1996348864 @default.
- W4293404329 cites W2001388611 @default.
- W4293404329 cites W2008312111 @default.
- W4293404329 cites W2010674151 @default.
- W4293404329 cites W2018973123 @default.
- W4293404329 cites W2019937806 @default.
- W4293404329 cites W2020531684 @default.
- W4293404329 cites W2027457043 @default.
- W4293404329 cites W2029450525 @default.
- W4293404329 cites W2032649896 @default.
- W4293404329 cites W2036755058 @default.
- W4293404329 cites W2038676786 @default.
- W4293404329 cites W2040969567 @default.
- W4293404329 cites W2046379282 @default.
- W4293404329 cites W2051255515 @default.
- W4293404329 cites W2052972273 @default.
- W4293404329 cites W2054752568 @default.
- W4293404329 cites W2055568103 @default.
- W4293404329 cites W2056227778 @default.
- W4293404329 cites W2056446394 @default.
- W4293404329 cites W2060709343 @default.
- W4293404329 cites W2063556118 @default.
- W4293404329 cites W2063738233 @default.
- W4293404329 cites W2067986039 @default.
- W4293404329 cites W2075357779 @default.
- W4293404329 cites W2075621261 @default.
- W4293404329 cites W2076300336 @default.
- W4293404329 cites W2077252523 @default.
- W4293404329 cites W2078157614 @default.
- W4293404329 cites W2079142229 @default.
- W4293404329 cites W2080791129 @default.
- W4293404329 cites W2083024009 @default.
- W4293404329 cites W2088727054 @default.
- W4293404329 cites W2092992881 @default.
- W4293404329 cites W2096736503 @default.
- W4293404329 cites W2104545571 @default.
- W4293404329 cites W2108116044 @default.
- W4293404329 cites W2112056285 @default.
- W4293404329 cites W2112085178 @default.
- W4293404329 cites W2113369613 @default.
- W4293404329 cites W2116793166 @default.
- W4293404329 cites W2118518129 @default.
- W4293404329 cites W2119674879 @default.
- W4293404329 cites W2126449884 @default.
- W4293404329 cites W2129652709 @default.
- W4293404329 cites W2130961728 @default.
- W4293404329 cites W2144160262 @default.
- W4293404329 cites W2149577695 @default.
- W4293404329 cites W2151222524 @default.
- W4293404329 cites W2152731121 @default.
- W4293404329 cites W2153056394 @default.
- W4293404329 cites W2157006220 @default.
- W4293404329 cites W2160140526 @default.
- W4293404329 cites W2163021747 @default.
- W4293404329 cites W2163605769 @default.
- W4293404329 cites W2164308593 @default.
- W4293404329 cites W2169495247 @default.
- W4293404329 cites W2187652773 @default.
- W4293404329 cites W2189444325 @default.
- W4293404329 cites W2227924439 @default.
- W4293404329 cites W2278405109 @default.
- W4293404329 cites W2339658711 @default.
- W4293404329 cites W2343892920 @default.
- W4293404329 cites W2471963949 @default.
- W4293404329 cites W2504176824 @default.
- W4293404329 cites W2505717852 @default.
- W4293404329 cites W2516187686 @default.
- W4293404329 cites W2539633045 @default.
- W4293404329 cites W2556223145 @default.
- W4293404329 cites W2561475925 @default.
- W4293404329 cites W2566974890 @default.
- W4293404329 cites W2580082637 @default.
- W4293404329 cites W2595711612 @default.
- W4293404329 cites W2600710373 @default.
- W4293404329 cites W2605414923 @default.
- W4293404329 cites W2606288377 @default.
- W4293404329 cites W2612643019 @default.
- W4293404329 cites W2619062389 @default.
- W4293404329 cites W2643917880 @default.
- W4293404329 cites W2749251018 @default.
- W4293404329 cites W2752189737 @default.
- W4293404329 cites W2768193247 @default.
- W4293404329 cites W2794278020 @default.
- W4293404329 cites W2797367925 @default.