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- W4293415889 abstract "Three new aconitine-type C19-diterpenoid alkaloids, richardsonines A-C (1–3), were isolated from the roots of Aconitum richardsonianum Lauener, together with seventeen known compounds (4–20). Their structures were elucidated by extensive spectroscopic analysis, and the absolute stereochemistry of 1 was confirmed by X-ray crystallography. Compounds 2, 5, 8 and 9 were rare C19-diterpenoid alkaloids bearing an OH group at C-16. Isolated compounds were evaluated for inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated neuroinflammatory responses in BV-2 microglial cells. Compounds 3 and 7 showed weak antineuroinflammatory effects with inhibition rates of 35.32 ± 2.29% and 39.94 ± 2.50%, respectively, at a concentration of 100 µM." @default.
- W4293415889 created "2022-08-29" @default.
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- W4293415889 date "2022-10-01" @default.
- W4293415889 modified "2023-10-18" @default.
- W4293415889 title "C19-Diterpenoid alkaloids from Aconitum richardsonianum" @default.
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- W4293415889 doi "https://doi.org/10.1016/j.phytol.2022.08.003" @default.
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