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• W4293417072 endingPage "4079" @default.
• W4293417072 startingPage "4069" @default.
• W4293417072 abstract "The nonphosphorylated neurofilament marker SMI-32 stains motor neurons in spinal cord slices and stains a subset of cultured spinal neurons [“large SMI-32(+) neurons”], which have a morphology consistent with motor neurons identified in vitro : large cell body, long axon, and extensive dendritic arborization. They are found preferentially in ventral spinal cord cultures, providing further evidence that large SMI-32(+) neurons are indeed motor neurons, and SMI-32 staining often colocalizes with established motor neuron markers (including acetylcholine, calcitonin gene-related peptide, and peripherin). Additionally, choline acetyltransferase activity (a frequently used index of the motor neuron population) and peripherin(+) neurons share with large SMI-32(+) neurons an unusual vulnerability to AMPA/kainate receptor-mediated injury. Kainate-induced loss of these motor neuron markers is Ca 2+ -dependent, which supports a critical role of Ca 2+ ions in this injury. Raising extracellular Ca 2+ exacerbates injury, whereas removal of extracellular Ca 2+ is protective. A basis for this vulnerability is provided by the observation that most peripherin(+) neurons, like large SMI-32(+) neurons, are subject to kainate-stimulated Co 2+ uptake, a histochemical stain that identifies neurons possessing Ca 2+ -permeable AMPA/kainate receptor-gated channels. Finally, of possibly greater relevance to the slow motor neuronal degeneration in diseases, both large SMI-32(+) neurons and peripherin(+) neurons are selectively damaged by prolonged (24 hr) low-level exposures to kainate (10 μ m ) or to the glutamate reuptake blocker l - trans -pyrrolidine-2,4-dicarboxylic acid (100 μ m ). During these low-level kainate exposures, large SMI-32(+) neurons showed higher intracellular Ca 2+ concentrations than most spinal neurons, suggesting that Ca 2+ ions are also important in this more slowly evolving injury." @default.
• W4293417072 created "2022-08-29" @default.
• W4293417072 creator A5000782482 @default.
• W4293417072 creator A5039756712 @default.
• W4293417072 creator A5043030783 @default.
• W4293417072 date "1996-07-01" @default.
• W4293417072 modified "2023-10-18" @default.
• W4293417072 title "Motor Neurons Are Selectively Vulnerable to AMPA/Kainate Receptor-Mediated Injury<b><i>In Vitro</i></b>" @default.
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• W4293417072 doi "https://doi.org/10.1523/jneurosci.16-13-04069.1996" @default.
• W4293417072 hasPublicationYear "1996" @default.
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