FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293419364> ?p ?o ?g. }

• W4293419364 abstract "Head and neck squamous cell carcinoma (HNSCC) represents one of the most prevalent and malignant tumors of epithelial origins with unfavorable outcomes. Increasing evidence has shown that dysregulated long non-coding RNAs (lncRNAs) correlate with tumorigenesis and genomic instability (GI), while the roles of GI-related lncRNAs in the tumor immune microenvironment (TIME) and predicting cancer therapy are still yet to be clarified. In this study, transcriptome and somatic mutation profiles with clinical parameters were obtained from the TCGA database. Patients were classified into GI-like and genomic stable (GS)-like groups according to the top 25% and bottom 25% cumulative counts of somatic mutations. Differentially expressed lncRNAs (DElncRNAs) between GI- and GS-like groups were identified as GI-related lncRNAs. These lncRNA-related coding genes were enriched in cancer-related KEGG pathways. Patients totaling 499 with clinical information were randomly divided into the training and validation sets. A total of 18 DElncRNAs screened by univariate Cox regression analysis were associated with overall survival (OS) in the training set. A GI-related lncRNA signature that comprised 10 DElncRNAs was generated through least absolute shrinkage and selection operator (Lasso)-Cox regression analysis. Patients in the high-risk group have significantly decreased OS vs. patients in the low-risk group, which was verified in internal validation and entire HNSCC sets. Integrated HNSCC sets from GEO confirmed the notable survival stratification of the signature. The time-dependent receiver operating characteristic curve demonstrated that the signature was reliable. In addition, the signature retained a strong performance of OS prediction for patients with various clinicopathological features. Cell composition analysis showed high anti-tumor immunity in the low-risk group which was evidenced by increased infiltrating CD8+ T cells and natural killer cells and reduced cancer-associated fibroblasts, which was convinced by immune signatures analysis via ssGSEA algorithm. T helper/IFNγ signaling, co-stimulatory, and co-inhibitory signatures showed increased expression in the low-risk group. Low-risk patients were predicted to be beneficial to immunotherapy, which was confirmed by patients with progressive disease who had high risk scores vs. complete remission patients. Furthermore, the drugs that might be sensitive to HNSCC were identified. In summary, the novel prognostic GILncRNA signature provided a promising approach for characterizing the TIME and predicting therapeutic strategies for HNSCC patients." @default.
• W4293419364 created "2022-08-29" @default.
• W4293419364 creator A5012820096 @default.
• W4293419364 creator A5071410718 @default.
• W4293419364 creator A5071706443 @default.
• W4293419364 date "2022-08-29" @default.
• W4293419364 modified "2023-09-26" @default.
• W4293419364 title "Characterization of tumor immune microenvironment and cancer therapy for head and neck squamous cell carcinoma through identification of a genomic instability-related lncRNA prognostic signature" @default.
• W4293419364 cites W1538419182 @default.
• W4293419364 cites W1749374281 @default.
• W4293419364 cites W1968000204 @default.
• W4293419364 cites W1981689158 @default.
• W4293419364 cites W1983316898 @default.
• W4293419364 cites W1985987855 @default.
• W4293419364 cites W1986241711 @default.
• W4293419364 cites W1990827580 @default.
• W4293419364 cites W2019448438 @default.
• W4293419364 cites W2059100079 @default.
• W4293419364 cites W2060850139 @default.
• W4293419364 cites W2075294566 @default.
• W4293419364 cites W2076419931 @default.
• W4293419364 cites W2077356468 @default.
• W4293419364 cites W2085483616 @default.
• W4293419364 cites W2087043640 @default.
• W4293419364 cites W2094736478 @default.
• W4293419364 cites W2099736081 @default.
• W4293419364 cites W2101675525 @default.
• W4293419364 cites W2102317912 @default.
• W4293419364 cites W2108068107 @default.
• W4293419364 cites W2118661657 @default.
• W4293419364 cites W2122357705 @default.
• W4293419364 cites W2129479910 @default.
• W4293419364 cites W2129548598 @default.
• W4293419364 cites W2130430382 @default.
• W4293419364 cites W2130473166 @default.
• W4293419364 cites W2131838114 @default.
• W4293419364 cites W2146512944 @default.
• W4293419364 cites W2162547088 @default.
• W4293419364 cites W2201760124 @default.
• W4293419364 cites W2267101106 @default.
• W4293419364 cites W2288651793 @default.
• W4293419364 cites W2290932069 @default.
• W4293419364 cites W2397540382 @default.
• W4293419364 cites W2404460484 @default.
• W4293419364 cites W2507880739 @default.
• W4293419364 cites W2533508881 @default.
• W4293419364 cites W2600132724 @default.
• W4293419364 cites W2600862208 @default.
• W4293419364 cites W2742662638 @default.
• W4293419364 cites W2760638321 @default.
• W4293419364 cites W2770553865 @default.
• W4293419364 cites W2779712643 @default.
• W4293419364 cites W2786031287 @default.
• W4293419364 cites W2794163856 @default.
• W4293419364 cites W2805703720 @default.
• W4293419364 cites W2810610846 @default.
• W4293419364 cites W2811451736 @default.
• W4293419364 cites W2896486010 @default.
• W4293419364 cites W2907190362 @default.
• W4293419364 cites W2908226200 @default.
• W4293419364 cites W2947554843 @default.
• W4293419364 cites W2948388080 @default.
• W4293419364 cites W2949273159 @default.
• W4293419364 cites W2952001873 @default.
• W4293419364 cites W2977153113 @default.
• W4293419364 cites W2982546850 @default.
• W4293419364 cites W2991034912 @default.
• W4293419364 cites W3003058300 @default.
• W4293419364 cites W3011044577 @default.
• W4293419364 cites W3012468089 @default.
• W4293419364 cites W3012657569 @default.
• W4293419364 cites W3026844837 @default.
• W4293419364 cites W3028187297 @default.
• W4293419364 cites W3089669346 @default.
• W4293419364 cites W3093169247 @default.
• W4293419364 cites W3095033445 @default.
• W4293419364 cites W3115880421 @default.
• W4293419364 cites W3128646645 @default.
• W4293419364 cites W3175752499 @default.
• W4293419364 cites W3189051599 @default.
• W4293419364 cites W3191480413 @default.
• W4293419364 cites W3191963331 @default.
• W4293419364 cites W3214029466 @default.
• W4293419364 cites W4200105605 @default.
• W4293419364 cites W4200119971 @default.
• W4293419364 cites W4200378939 @default.
• W4293419364 cites W4205087978 @default.
• W4293419364 cites W4206789280 @default.
• W4293419364 cites W4206841660 @default.
• W4293419364 cites W4210468274 @default.
• W4293419364 cites W4224325869 @default.
• W4293419364 cites W4225963795 @default.
• W4293419364 cites W4226278245 @default.
• W4293419364 cites W4280539627 @default.
• W4293419364 cites W2440796175 @default.
• W4293419364 doi "https://doi.org/10.3389/fgene.2022.979575" @default.
• W4293419364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36105083" @default.
• W4293419364 hasPublicationYear "2022" @default.
• W4293419364 type Work @default.
• W4293419364 citedByCount "2" @default.

• next