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• W4293432236 endingPage "4748" @default.
• W4293432236 startingPage "4742" @default.
• W4293432236 abstract "Lipopolysaccharide (LPS), an endotoxin, produces pain behavior, inflammation, and changes in immune function. Many of these effects are secondary to the production of cytokines. In the present study, we investigated the effect of LPS on the releasing function of afferent terminals as measured by calcitonin gene-related peptide (CGRP) release in ex vivo perfused rat trachea, and examined the possible role of the cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) as intermediaries in this effect. Systemic injection of LPS (0.75 mg/kg, i.p.) in adult rats induced an increase in body temperature followed by hypothermia, indicating ongoing infection. We observed that capsaicin-induced (0.1 μ m ) tracheal CGRP release was significantly enhanced in the LPS-treated animals after 5 hr. This enhancement of the peptide release by LPS was blocked by IL-1β tripeptide antagonist Lys- d -Pro-Thr (10 μ m ) and mimicked by IL-1β and TNF-α (10–100 pg/ml), suggesting that the potentiating effect of LPS on CGRP release is mediated by generation of IL-1β and TNF-α. IL-1β-induced augmentation of CGRP release was blocked by Lys- d -Pro-Thr. Additionally, the cyclooxygenase inhibitor ketorolac (10 μ m ) significantly attenuated the facilitatory effects of LPS and IL-1β, indicating involvement of prostanoids. These findings suggest that endotoxin treatment generated cytokines such as IL-1β and TNF-α that regulated the peripheral releasing function of primary sensory afferents by sensitizing the terminals and facilitating peptide release. This effect is prostanoid dependent." @default.
• W4293432236 created "2022-08-29" @default.
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• W4293432236 date "1996-08-01" @default.
• W4293432236 modified "2023-10-02" @default.
• W4293432236 title "Involvement of Cytokines in Lipopolysaccharide-Induced Facilitation of CGRP Release from Capsaicin-Sensitive Nerves in the Trachea: Studies with Interleukin-1β and Tumor Necrosis Factor-α" @default.
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• W4293432236 doi "https://doi.org/10.1523/jneurosci.16-15-04742.1996" @default.
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