Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293435906> ?p ?o ?g. }
- W4293435906 abstract "Cells remodel their cytoplasm with force-generating cytoskeletal motors. Their activity generates random forces that stir the cytoplasm, agitating and displacing membrane-bound organelles like the nucleus in somatic and germ cells. These forces are transmitted inside the nucleus, yet their consequences on liquid-like biomolecular condensates residing in the nucleus remain unexplored. Here, we probe experimentally and computationally diverse nuclear condensates, that include nuclear speckles, Cajal bodies, and nucleoli, during cytoplasmic remodeling of female germ cells named oocytes. We discover that growing mammalian oocytes deploy cytoplasmic forces to timely impose multiscale reorganization of nuclear condensates for the success of meiotic divisions. These cytoplasmic forces accelerate nuclear condensate collision-coalescence and molecular kinetics within condensates. Disrupting the forces decelerates nuclear condensate reorganization on both scales, which correlates with compromised condensate-associated mRNA processing and hindered oocyte divisions that drive female fertility. We establish that cytoplasmic forces can reorganize nuclear condensates in an evolutionary conserved fashion in insects. Our work implies that cells evolved a mechanism, based on cytoplasmic force tuning, to functionally regulate a broad range of nuclear condensates across scales. This finding opens new perspectives when studying condensate-associated pathologies like cancer, neurodegeneration and viral infections." @default.
- W4293435906 created "2022-08-29" @default.
- W4293435906 creator A5017317489 @default.
- W4293435906 creator A5020888320 @default.
- W4293435906 creator A5029603747 @default.
- W4293435906 creator A5032487819 @default.
- W4293435906 creator A5038635374 @default.
- W4293435906 creator A5047173835 @default.
- W4293435906 creator A5054027067 @default.
- W4293435906 creator A5062039839 @default.
- W4293435906 creator A5075431905 @default.
- W4293435906 creator A5077179422 @default.
- W4293435906 creator A5085588285 @default.
- W4293435906 creator A5089277246 @default.
- W4293435906 date "2022-08-29" @default.
- W4293435906 modified "2023-10-12" @default.
- W4293435906 title "Cytoplasmic forces functionally reorganize nuclear condensates in oocytes" @default.
- W4293435906 cites W1564176844 @default.
- W4293435906 cites W1830147006 @default.
- W4293435906 cites W1966278477 @default.
- W4293435906 cites W1968445136 @default.
- W4293435906 cites W1974708640 @default.
- W4293435906 cites W1983489516 @default.
- W4293435906 cites W2009274826 @default.
- W4293435906 cites W2012628447 @default.
- W4293435906 cites W2014327850 @default.
- W4293435906 cites W2021161932 @default.
- W4293435906 cites W2024857915 @default.
- W4293435906 cites W2046963960 @default.
- W4293435906 cites W2059190326 @default.
- W4293435906 cites W2063530272 @default.
- W4293435906 cites W2065305930 @default.
- W4293435906 cites W2067055806 @default.
- W4293435906 cites W2067547076 @default.
- W4293435906 cites W2068524116 @default.
- W4293435906 cites W2077285952 @default.
- W4293435906 cites W2079465654 @default.
- W4293435906 cites W2081406767 @default.
- W4293435906 cites W2084030174 @default.
- W4293435906 cites W2084167911 @default.
- W4293435906 cites W2087001748 @default.
- W4293435906 cites W2090380244 @default.
- W4293435906 cites W2105199381 @default.
- W4293435906 cites W2111796925 @default.
- W4293435906 cites W2112731182 @default.
- W4293435906 cites W2117719695 @default.
- W4293435906 cites W2119204091 @default.
- W4293435906 cites W2122062804 @default.
- W4293435906 cites W2122823449 @default.
- W4293435906 cites W2124136123 @default.
- W4293435906 cites W2133482368 @default.
- W4293435906 cites W2133660324 @default.
- W4293435906 cites W2136817553 @default.
- W4293435906 cites W2138431129 @default.
- W4293435906 cites W2146412869 @default.
- W4293435906 cites W2151382826 @default.
- W4293435906 cites W2160683304 @default.
- W4293435906 cites W2170551349 @default.
- W4293435906 cites W2217663772 @default.
- W4293435906 cites W2345356016 @default.
- W4293435906 cites W2461515153 @default.
- W4293435906 cites W2519157528 @default.
- W4293435906 cites W2520442947 @default.
- W4293435906 cites W2590568317 @default.
- W4293435906 cites W2607184951 @default.
- W4293435906 cites W2618657542 @default.
- W4293435906 cites W2618874495 @default.
- W4293435906 cites W2620496126 @default.
- W4293435906 cites W2694038906 @default.
- W4293435906 cites W2749378623 @default.
- W4293435906 cites W2755023008 @default.
- W4293435906 cites W2755175368 @default.
- W4293435906 cites W2756821926 @default.
- W4293435906 cites W2765387868 @default.
- W4293435906 cites W2765609286 @default.
- W4293435906 cites W2883737532 @default.
- W4293435906 cites W2883886443 @default.
- W4293435906 cites W2892227351 @default.
- W4293435906 cites W2898560457 @default.
- W4293435906 cites W2903481608 @default.
- W4293435906 cites W2910305526 @default.
- W4293435906 cites W2949324846 @default.
- W4293435906 cites W2951856423 @default.
- W4293435906 cites W2964849163 @default.
- W4293435906 cites W2969279439 @default.
- W4293435906 cites W2979490003 @default.
- W4293435906 cites W2999583767 @default.
- W4293435906 cites W3003719244 @default.
- W4293435906 cites W3042510281 @default.
- W4293435906 cites W3044717219 @default.
- W4293435906 cites W3094115889 @default.
- W4293435906 cites W3099323319 @default.
- W4293435906 cites W3102868101 @default.
- W4293435906 cites W3111092509 @default.
- W4293435906 cites W3112272587 @default.
- W4293435906 cites W3118554598 @default.
- W4293435906 cites W3120286568 @default.
- W4293435906 cites W3120553706 @default.
- W4293435906 cites W3123015207 @default.
- W4293435906 cites W3182146416 @default.