Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293451387> ?p ?o ?g. }
- W4293451387 endingPage "1814" @default.
- W4293451387 startingPage "1802" @default.
- W4293451387 abstract "Early inflammation following acute ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PCI) affects myocardial infarct (MI) size and left ventricular remodeling. The mammalian target of rapamycin (mTOR) is involved in the enhanced inflammatory response and its inhibition has exerted beneficial effects on MI size in preclinical models of acute MI.The CLEVER-ACS (Controlled Level Everolimus in Acute Coronary Syndromes) trial evaluated the effects of targeting inflammation by mTOR inhibition in patients with STEMI undergoing PCI.CLEVER-ACS was a randomized, multicenter, international, double-blind, placebo-controlled trial. A total of 150 patients with STEMI undergoing PCI were randomly assigned to oral everolimus (days 1-3: 7.5 mg daily; days 4-5: 5.0 mg daily) or placebo for 5 days. The primary endpoint was the change in MI size. The secondary endpoint was the change in microvascular obstruction (MVO) from baseline (12 hours to 5 days after PCI) to 30 days as assessed by cardiac magnetic resonance imaging.The changes in MI size from baseline to 30 days, the primary endpoint, were -14.2 g (95% CI: -17.4 to -11.1 g) and -12.3 g (95% CI: -16.0 to -8.7 g) in the everolimus and placebo groups (P = 0.99). Corresponding changes in MVO were -4.8 g (95% CI: -6.7 to -2.9 g) and -6.3 g (95% CI: -8.7 to -4.0 g) in the everolimus and placebo groups (P = 0.14). Adverse events did not differ between the study groups.Among STEMI patients undergoing PCI, early mTOR inhibition with everolimus did not reduce MI size or MVO at 30 days. (CLEVER-ACS [Controlled Level Everolimus in Acute Coronary Syndromes; NCT01529554)." @default.
- W4293451387 created "2022-08-29" @default.
- W4293451387 creator A5001666794 @default.
- W4293451387 creator A5003436368 @default.
- W4293451387 creator A5004607703 @default.
- W4293451387 creator A5007105515 @default.
- W4293451387 creator A5010936003 @default.
- W4293451387 creator A5011706820 @default.
- W4293451387 creator A5013727186 @default.
- W4293451387 creator A5020952304 @default.
- W4293451387 creator A5023566983 @default.
- W4293451387 creator A5027046285 @default.
- W4293451387 creator A5035254382 @default.
- W4293451387 creator A5040134218 @default.
- W4293451387 creator A5040563213 @default.
- W4293451387 creator A5045293936 @default.
- W4293451387 creator A5045354508 @default.
- W4293451387 creator A5046293028 @default.
- W4293451387 creator A5051530432 @default.
- W4293451387 creator A5053194091 @default.
- W4293451387 creator A5060430047 @default.
- W4293451387 creator A5064779298 @default.
- W4293451387 creator A5071710901 @default.
- W4293451387 creator A5075035084 @default.
- W4293451387 creator A5079767121 @default.
- W4293451387 creator A5080753934 @default.
- W4293451387 creator A5083712331 @default.
- W4293451387 creator A5085573148 @default.
- W4293451387 creator A5089821635 @default.
- W4293451387 creator A5090936485 @default.
- W4293451387 date "2022-11-01" @default.
- W4293451387 modified "2023-09-29" @default.
- W4293451387 title "Mammalian Target of Rapamycin Inhibition in Patients With ST-Segment Elevation Myocardial Infarction" @default.
- W4293451387 cites W1973404873 @default.
- W4293451387 cites W1981567283 @default.
- W4293451387 cites W1982737375 @default.
- W4293451387 cites W1999747561 @default.
- W4293451387 cites W2009483242 @default.
- W4293451387 cites W2031773478 @default.
- W4293451387 cites W2051395985 @default.
- W4293451387 cites W206343883 @default.
- W4293451387 cites W2065152591 @default.
- W4293451387 cites W2090648684 @default.
- W4293451387 cites W2104765420 @default.
- W4293451387 cites W2134738156 @default.
- W4293451387 cites W2151970753 @default.
- W4293451387 cites W2153322653 @default.
- W4293451387 cites W2155170855 @default.
- W4293451387 cites W2155668811 @default.
- W4293451387 cites W2340015041 @default.
- W4293451387 cites W2343539326 @default.
- W4293451387 cites W2464715045 @default.
- W4293451387 cites W2549980743 @default.
- W4293451387 cites W2591038040 @default.
- W4293451387 cites W2748400555 @default.
- W4293451387 cites W2754054868 @default.
- W4293451387 cites W2789055329 @default.
- W4293451387 cites W2799730310 @default.
- W4293451387 cites W2810050135 @default.
- W4293451387 cites W2906208557 @default.
- W4293451387 cites W2907012814 @default.
- W4293451387 cites W2919288695 @default.
- W4293451387 cites W2936225573 @default.
- W4293451387 cites W2961167129 @default.
- W4293451387 cites W2986700515 @default.
- W4293451387 cites W3081761942 @default.
- W4293451387 cites W3127644994 @default.
- W4293451387 cites W3153495812 @default.
- W4293451387 cites W3194925641 @default.
- W4293451387 cites W4210679016 @default.
- W4293451387 cites W4211134725 @default.
- W4293451387 cites W66281379 @default.
- W4293451387 cites W96597366 @default.
- W4293451387 doi "https://doi.org/10.1016/j.jacc.2022.08.747" @default.
- W4293451387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36049557" @default.
- W4293451387 hasPublicationYear "2022" @default.
- W4293451387 type Work @default.
- W4293451387 citedByCount "7" @default.
- W4293451387 countsByYear W42934513872022 @default.
- W4293451387 countsByYear W42934513872023 @default.
- W4293451387 crossrefType "journal-article" @default.
- W4293451387 hasAuthorship W4293451387A5001666794 @default.
- W4293451387 hasAuthorship W4293451387A5003436368 @default.
- W4293451387 hasAuthorship W4293451387A5004607703 @default.
- W4293451387 hasAuthorship W4293451387A5007105515 @default.
- W4293451387 hasAuthorship W4293451387A5010936003 @default.
- W4293451387 hasAuthorship W4293451387A5011706820 @default.
- W4293451387 hasAuthorship W4293451387A5013727186 @default.
- W4293451387 hasAuthorship W4293451387A5020952304 @default.
- W4293451387 hasAuthorship W4293451387A5023566983 @default.
- W4293451387 hasAuthorship W4293451387A5027046285 @default.
- W4293451387 hasAuthorship W4293451387A5035254382 @default.
- W4293451387 hasAuthorship W4293451387A5040134218 @default.
- W4293451387 hasAuthorship W4293451387A5040563213 @default.
- W4293451387 hasAuthorship W4293451387A5045293936 @default.
- W4293451387 hasAuthorship W4293451387A5045354508 @default.
- W4293451387 hasAuthorship W4293451387A5046293028 @default.
- W4293451387 hasAuthorship W4293451387A5051530432 @default.