Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293463485> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4293463485 abstract "BACKGROUND Brigatinib is used for anaplastic lymphoma kinase (ALK)-positive lung cancer treatment, and some research showed it was useful in treating triple-mutant epidermal growth factor receptor lung cancer. Clinical trials have shown some potential pulmonary toxicities of brigatinib. The early-onset pulmonary events (EOPEs) of brigatinib are associated with high dosage and older age. The successful treatment of EOPEs with steroids was reported. We present the case of a patient with epidermal growth factor receptor L858R/cis-T790M/cis-C797S triple mutations who developed EOPEs after using brigatinib together with afatinib, and the patient was successfully treated with high-dose steroids. CASE REPORT A 54-year-old woman with underlying stage IV lung adenocarcinoma, ECOG score of 0, was treated with brigatinib and afatinib due to disease progression secondary to L858R/cis-T790M/cis-C797S triple mutations. After starting brigatinib and afatinib, she developed dyspnea and dry cough within 2 days and was intubated due to hypercapnic respiratory failure. The chest X-ray showed bilateral interstitial infiltrates while chest computed tomography (CT) showed bilateral ground-glass opacities. EOPEs were suspected and methylprednisolone was prescribed. The oxygenation of the patient improved and her chest CT showed complete resolution after 2 weeks of steroid treatment. CONCLUSIONS This is the first reported case in which brigatinib combined with afatinib induced EOPEs in a patient with triple-mutant epidermal growth factor receptors of lung cancer. Use of doubled tyrosine kinase inhibitors may result in increased risk of pulmonary toxicities that require high alertness, and the respiratory symptoms should be monitored closely after prescription. The early treatment of EOPEs with high-dose steroids resulted in remarkable improvement." @default.
- W4293463485 created "2022-08-29" @default.
- W4293463485 creator A5008280907 @default.
- W4293463485 creator A5012943560 @default.
- W4293463485 creator A5079691564 @default.
- W4293463485 creator A5089849004 @default.
- W4293463485 date "2022-08-22" @default.
- W4293463485 modified "2023-09-27" @default.
- W4293463485 title "Early-Onset Pulmonary Events with Combined Brigatinib and Afatinib Treatment of L858/cisT790M/cisC797S NSCLC: A Case Report" @default.
- W4293463485 cites W2551769647 @default.
- W4293463485 cites W2595645511 @default.
- W4293463485 cites W2891556735 @default.
- W4293463485 cites W2945201835 @default.
- W4293463485 cites W3020050719 @default.
- W4293463485 cites W3148970978 @default.
- W4293463485 doi "https://doi.org/10.12659/ajcr.937209" @default.
- W4293463485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36146910" @default.
- W4293463485 hasPublicationYear "2022" @default.
- W4293463485 type Work @default.
- W4293463485 citedByCount "1" @default.
- W4293463485 countsByYear W42934634852023 @default.
- W4293463485 crossrefType "journal-article" @default.
- W4293463485 hasAuthorship W4293463485A5008280907 @default.
- W4293463485 hasAuthorship W4293463485A5012943560 @default.
- W4293463485 hasAuthorship W4293463485A5079691564 @default.
- W4293463485 hasAuthorship W4293463485A5089849004 @default.
- W4293463485 hasBestOaLocation W42934634852 @default.
- W4293463485 hasConcept C117643217 @default.
- W4293463485 hasConcept C121608353 @default.
- W4293463485 hasConcept C126322002 @default.
- W4293463485 hasConcept C143998085 @default.
- W4293463485 hasConcept C2776232967 @default.
- W4293463485 hasConcept C2776256026 @default.
- W4293463485 hasConcept C2777930144 @default.
- W4293463485 hasConcept C2779422266 @default.
- W4293463485 hasConcept C2779438470 @default.
- W4293463485 hasConcept C2780580887 @default.
- W4293463485 hasConcept C2780586478 @default.
- W4293463485 hasConcept C71924100 @default.
- W4293463485 hasConceptScore W4293463485C117643217 @default.
- W4293463485 hasConceptScore W4293463485C121608353 @default.
- W4293463485 hasConceptScore W4293463485C126322002 @default.
- W4293463485 hasConceptScore W4293463485C143998085 @default.
- W4293463485 hasConceptScore W4293463485C2776232967 @default.
- W4293463485 hasConceptScore W4293463485C2776256026 @default.
- W4293463485 hasConceptScore W4293463485C2777930144 @default.
- W4293463485 hasConceptScore W4293463485C2779422266 @default.
- W4293463485 hasConceptScore W4293463485C2779438470 @default.
- W4293463485 hasConceptScore W4293463485C2780580887 @default.
- W4293463485 hasConceptScore W4293463485C2780586478 @default.
- W4293463485 hasConceptScore W4293463485C71924100 @default.
- W4293463485 hasLocation W42934634851 @default.
- W4293463485 hasLocation W42934634852 @default.
- W4293463485 hasLocation W42934634853 @default.
- W4293463485 hasOpenAccess W4293463485 @default.
- W4293463485 hasPrimaryLocation W42934634851 @default.
- W4293463485 hasRelatedWork W1883962419 @default.
- W4293463485 hasRelatedWork W2015138929 @default.
- W4293463485 hasRelatedWork W2078135026 @default.
- W4293463485 hasRelatedWork W2078915908 @default.
- W4293463485 hasRelatedWork W2278778992 @default.
- W4293463485 hasRelatedWork W2503069423 @default.
- W4293463485 hasRelatedWork W2613038040 @default.
- W4293463485 hasRelatedWork W2922073436 @default.
- W4293463485 hasRelatedWork W3000070469 @default.
- W4293463485 hasRelatedWork W3183634825 @default.
- W4293463485 hasVolume "23" @default.
- W4293463485 isParatext "false" @default.
- W4293463485 isRetracted "false" @default.
- W4293463485 workType "article" @default.