Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293474928> ?p ?o ?g. }
- W4293474928 endingPage "103306" @default.
- W4293474928 startingPage "103306" @default.
- W4293474928 abstract "Brown adipose tissue is a thermogenic organ, which consumes chemical energy as heat to protect animals from low temperature and metabolic diseases. However, the role and mechanism of the new factor that up-regulates the heat-generating capacity of brown adipose tissue is still unclear. Here, we found that hepatitis C virus core binding protein 6 (HCBP6), as a key regulator gene in the homeostasis of liver lipid metabolism, is an important enhancer for activating brown fat to ensure thermogenesis. HCBP6 upregulates the expression of UCP1 and increases the number of mitochondria in brown adipocytes. In the BAT of HCBP6-knockout mice induced by a high-fat diet, UCP1 and BAT activity-related genes Pgc1α, Cidea and oxidation phosphorylation-related genes (OXPHOS) were significantly reduced. In addition, the transcriptomics results show that the loss of HCBP6 caused disorder of the metabolic pathway, the expression of brown adipocyte development genes was significantly reduced, and the expression of most BAT cytokine genes was reduced. In conclusion, HCBP6 increased ucp1-dependent thermogenesis in BAT and improved liver lipid metabolism, possibly by enhancing the activity of brown fat and changing the expression of BAT cytokine genes." @default.
- W4293474928 created "2022-08-29" @default.
- W4293474928 creator A5000449183 @default.
- W4293474928 creator A5008616844 @default.
- W4293474928 creator A5013260601 @default.
- W4293474928 creator A5034322308 @default.
- W4293474928 creator A5044481624 @default.
- W4293474928 creator A5065087562 @default.
- W4293474928 creator A5071773009 @default.
- W4293474928 creator A5074614470 @default.
- W4293474928 date "2022-10-01" @default.
- W4293474928 modified "2023-09-30" @default.
- W4293474928 title "HCBP6-induced activation of brown adipose tissue and upregulated of BAT cytokines genes" @default.
- W4293474928 cites W1575263278 @default.
- W4293474928 cites W1617522034 @default.
- W4293474928 cites W1981525131 @default.
- W4293474928 cites W2008150005 @default.
- W4293474928 cites W2013891116 @default.
- W4293474928 cites W2027059985 @default.
- W4293474928 cites W2032677261 @default.
- W4293474928 cites W2037030202 @default.
- W4293474928 cites W2044190642 @default.
- W4293474928 cites W2051993213 @default.
- W4293474928 cites W2053727415 @default.
- W4293474928 cites W2054468779 @default.
- W4293474928 cites W2064902611 @default.
- W4293474928 cites W2065736951 @default.
- W4293474928 cites W2074659742 @default.
- W4293474928 cites W2098926154 @default.
- W4293474928 cites W2106287756 @default.
- W4293474928 cites W2107465793 @default.
- W4293474928 cites W2123371309 @default.
- W4293474928 cites W2127690282 @default.
- W4293474928 cites W2128538324 @default.
- W4293474928 cites W2135262167 @default.
- W4293474928 cites W2142296587 @default.
- W4293474928 cites W2154162312 @default.
- W4293474928 cites W2162023168 @default.
- W4293474928 cites W2168536185 @default.
- W4293474928 cites W2168792880 @default.
- W4293474928 cites W2275092747 @default.
- W4293474928 cites W2532265207 @default.
- W4293474928 cites W2547723868 @default.
- W4293474928 cites W2604914239 @default.
- W4293474928 cites W2608328170 @default.
- W4293474928 cites W2786532932 @default.
- W4293474928 cites W2800612868 @default.
- W4293474928 cites W2803730561 @default.
- W4293474928 cites W2942796204 @default.
- W4293474928 cites W3034850822 @default.
- W4293474928 cites W3047314584 @default.
- W4293474928 cites W3088698228 @default.
- W4293474928 doi "https://doi.org/10.1016/j.jtherbio.2022.103306" @default.
- W4293474928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36195403" @default.
- W4293474928 hasPublicationYear "2022" @default.
- W4293474928 type Work @default.
- W4293474928 citedByCount "0" @default.
- W4293474928 crossrefType "journal-article" @default.
- W4293474928 hasAuthorship W4293474928A5000449183 @default.
- W4293474928 hasAuthorship W4293474928A5008616844 @default.
- W4293474928 hasAuthorship W4293474928A5013260601 @default.
- W4293474928 hasAuthorship W4293474928A5034322308 @default.
- W4293474928 hasAuthorship W4293474928A5044481624 @default.
- W4293474928 hasAuthorship W4293474928A5065087562 @default.
- W4293474928 hasAuthorship W4293474928A5071773009 @default.
- W4293474928 hasAuthorship W4293474928A5074614470 @default.
- W4293474928 hasConcept C104317684 @default.
- W4293474928 hasConcept C126322002 @default.
- W4293474928 hasConcept C127561419 @default.
- W4293474928 hasConcept C134018914 @default.
- W4293474928 hasConcept C143128242 @default.
- W4293474928 hasConcept C151279926 @default.
- W4293474928 hasConcept C171089720 @default.
- W4293474928 hasConcept C2776175234 @default.
- W4293474928 hasConcept C2780642333 @default.
- W4293474928 hasConcept C4733338 @default.
- W4293474928 hasConcept C55493867 @default.
- W4293474928 hasConcept C57600042 @default.
- W4293474928 hasConcept C71924100 @default.
- W4293474928 hasConcept C81979416 @default.
- W4293474928 hasConcept C86803240 @default.
- W4293474928 hasConcept C95444343 @default.
- W4293474928 hasConceptScore W4293474928C104317684 @default.
- W4293474928 hasConceptScore W4293474928C126322002 @default.
- W4293474928 hasConceptScore W4293474928C127561419 @default.
- W4293474928 hasConceptScore W4293474928C134018914 @default.
- W4293474928 hasConceptScore W4293474928C143128242 @default.
- W4293474928 hasConceptScore W4293474928C151279926 @default.
- W4293474928 hasConceptScore W4293474928C171089720 @default.
- W4293474928 hasConceptScore W4293474928C2776175234 @default.
- W4293474928 hasConceptScore W4293474928C2780642333 @default.
- W4293474928 hasConceptScore W4293474928C4733338 @default.
- W4293474928 hasConceptScore W4293474928C55493867 @default.
- W4293474928 hasConceptScore W4293474928C57600042 @default.
- W4293474928 hasConceptScore W4293474928C71924100 @default.
- W4293474928 hasConceptScore W4293474928C81979416 @default.
- W4293474928 hasConceptScore W4293474928C86803240 @default.
- W4293474928 hasConceptScore W4293474928C95444343 @default.