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- W4293485771 abstract "Abstract Tumor phenotype is shaped both by transforming genomic alterations and the normal cell-of-origin. We identified a cell-of-origin associated prognostic gene expression signature, ET-9, that correlates with remarkably shorter overall and relapse free breast cancer survival, 8.7 and 6.2 years respectively. The genes associated with the ET-9 signature are regulated by histone deacetylase 7 (HDAC7) partly through ZNF92, a previously unexplored transcription factor with a single PubMed citation since its cloning in 1990s. Remarkably, ZNF92 is distinctively over-expressed in breast cancer compared to other tumor types, on a par with the breast cancer specificity of the estrogen receptor. Importantly, ET-9 signature appears to be independent of proliferation, and correlates with outcome in lymph-node positive, HER2+, post-chemotherapy and triple-negative breast cancers. These features distinguish ET-9 from existing breast cancer prognostic signatures that are generally related to proliferation and correlate with outcome in lymph-node negative, ER-positive, HER2-negative breast cancers. Our results suggest that ET-9 could be also utilized as a predictive signature to select patients for HDAC inhibitor treatment." @default.
- W4293485771 created "2022-08-29" @default.
- W4293485771 creator A5008438901 @default.
- W4293485771 creator A5019985750 @default.
- W4293485771 creator A5024465077 @default.
- W4293485771 creator A5034884631 @default.
- W4293485771 creator A5079978893 @default.
- W4293485771 date "2022-08-29" @default.
- W4293485771 modified "2023-10-18" @default.
- W4293485771 title "ZNF92, an unexplored transcription factor with remarkably distinct breast cancer over-expression associated with prognosis and cell-of-origin" @default.
- W4293485771 cites W1498558807 @default.
- W4293485771 cites W1545398558 @default.
- W4293485771 cites W1791571505 @default.
- W4293485771 cites W1971992633 @default.
- W4293485771 cites W1975903971 @default.
- W4293485771 cites W1982829069 @default.
- W4293485771 cites W1983570241 @default.
- W4293485771 cites W1986400812 @default.
- W4293485771 cites W1986553481 @default.
- W4293485771 cites W2005134173 @default.
- W4293485771 cites W2005895632 @default.
- W4293485771 cites W2013870404 @default.
- W4293485771 cites W2015994834 @default.
- W4293485771 cites W2016937576 @default.
- W4293485771 cites W2022397091 @default.
- W4293485771 cites W2028236537 @default.
- W4293485771 cites W2029226634 @default.
- W4293485771 cites W2037915750 @default.
- W4293485771 cites W2041783360 @default.
- W4293485771 cites W2044638469 @default.
- W4293485771 cites W2055327776 @default.
- W4293485771 cites W2060320701 @default.
- W4293485771 cites W2068073301 @default.
- W4293485771 cites W2077523070 @default.
- W4293485771 cites W2078000027 @default.
- W4293485771 cites W2081777966 @default.
- W4293485771 cites W2107556256 @default.
- W4293485771 cites W2109154714 @default.
- W4293485771 cites W2114843025 @default.
- W4293485771 cites W2117692326 @default.
- W4293485771 cites W2121139881 @default.
- W4293485771 cites W2121565438 @default.
- W4293485771 cites W2123752216 @default.
- W4293485771 cites W2125508691 @default.
- W4293485771 cites W2134582937 @default.
- W4293485771 cites W2135780800 @default.
- W4293485771 cites W2142280045 @default.
- W4293485771 cites W2143759761 @default.
- W4293485771 cites W2153475997 @default.
- W4293485771 cites W2155631307 @default.
- W4293485771 cites W2157840751 @default.
- W4293485771 cites W2163570884 @default.
- W4293485771 cites W2167291962 @default.
- W4293485771 cites W2167986022 @default.
- W4293485771 cites W2344022496 @default.
- W4293485771 cites W2375577403 @default.
- W4293485771 cites W2485355719 @default.
- W4293485771 cites W2502622880 @default.
- W4293485771 cites W2527902762 @default.
- W4293485771 cites W2582908162 @default.
- W4293485771 cites W2586874799 @default.
- W4293485771 cites W2613647981 @default.
- W4293485771 cites W2752303484 @default.
- W4293485771 cites W2757400603 @default.
- W4293485771 cites W2768315237 @default.
- W4293485771 cites W2773563971 @default.
- W4293485771 cites W2782400196 @default.
- W4293485771 cites W2795757028 @default.
- W4293485771 cites W2796153844 @default.
- W4293485771 cites W2802202063 @default.
- W4293485771 cites W2886726729 @default.
- W4293485771 cites W2891814599 @default.
- W4293485771 cites W2892313793 @default.
- W4293485771 cites W2896162816 @default.
- W4293485771 cites W2899939830 @default.
- W4293485771 cites W2909093842 @default.
- W4293485771 cites W2913682450 @default.
- W4293485771 cites W2925658440 @default.
- W4293485771 cites W2951185039 @default.
- W4293485771 cites W2951545629 @default.
- W4293485771 cites W2966048051 @default.
- W4293485771 cites W2966761209 @default.
- W4293485771 cites W2982663851 @default.
- W4293485771 cites W2992248157 @default.
- W4293485771 cites W2997517973 @default.
- W4293485771 cites W3005607709 @default.
- W4293485771 cites W3015979847 @default.
- W4293485771 cites W3021322531 @default.
- W4293485771 cites W3044611194 @default.
- W4293485771 cites W3046931490 @default.
- W4293485771 cites W3120668803 @default.
- W4293485771 cites W3122101699 @default.
- W4293485771 cites W3122239571 @default.
- W4293485771 cites W3127176988 @default.
- W4293485771 cites W3128449602 @default.
- W4293485771 cites W3135882325 @default.
- W4293485771 cites W3135974134 @default.
- W4293485771 cites W3137025154 @default.
- W4293485771 cites W3140422000 @default.
- W4293485771 cites W3154244319 @default.