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• W4293491600 abstract "To determine whether tumor shear stiffness, as measured by magnetic resonance elastography, corresponds with intratumoral consistency and histotype. A total of 88 patients with 89 meningiomas (grade 1, 74 typical [13 fibroblastic, 61 non-fibroblastic]; grade 2, 12 atypical; grade 3, 3 anaplastic) were prospectively studied, each undergoing preoperative MRE in conjunction with T1-, T2- and diffusion-weighted imaging. Contrast-enhanced T1-weighted sequences were also obtained. Tumor consistency was evaluated as heterogeneous or homogenous, and graded on a 5-point scale intraoperatively. MRE-determined shear stiffness was associated with tumor consistency by surgeon’s evaluation and whole-slide histologic analyses. Mean tumor stiffness overall was 3.81+/-1.74 kPa (range, 1.57-12.60 kPa), correlating well with intraoperative scoring (r=0.748; p=0.001). MRE performed well as a gauge of tumor consistency (AUC=0.879, 95% CI: 0.792-0.938) and heterogeneity (AUC=0.773, 95% CI: 0.618-0.813), significantly surpassing conventional MR techniques (DeLong test, all p<0.001 after Bonferroni adjustment). Shear stiffness was independently correlated with both fibrous content (partial correlation coefficient=0.752; p<0.001) and tumor cellularity (partial correlation coefficient=0.547; p<0.001). MRE outperformed other imaging techniques in distinguishing fibroblastic meningiomas from other histotypes (AUC=0.835 vs 0.513∼0.634; all p<0.05), but showed limited ability to differentiate atypical or anaplastic meningiomas from typical meningiomas (AUC=0.723 vs 0.616∼0.775; all p>0.05). Small (<2.5 cm, n=6) and intraventricular (n=2) tumors displayed inconsistencies between MRE and surgeon’s evaluation. The results of this prospective study provide substantial evidence that preoperative evaluation of meningiomas with MRE can reliably characterize tumor stiffness and spatial heterogeneity to aid neurosurgical planning." @default.
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• W4293491600 date "2022-01-01" @default.
• W4293491600 modified "2023-10-12" @default.
• W4293491600 title "Use of magnetic resonance elastography to gauge meningioma intratumoral consistency and histotype" @default.
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• W4293491600 doi "https://doi.org/10.1016/j.nicl.2022.103173" @default.
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