FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293491624> ?p ?o ?g. }

• W4293491624 endingPage "659" @default.
• W4293491624 startingPage "642" @default.
• W4293491624 abstract "Imbalance in lipid homeostasis is associated with discrepancies in immune signaling and is tightly linked to metabolic disorders. The diverse ways in which lipids impact immune signaling, however, remain ambiguous. The phospholipid phosphatidylinositol (PI), which is implicated in numerous immune disorders, is chiefly defined by its phosphorylation status. By contrast, the significance of the two fatty acid chains attached to the PI remains unknown. In this study, by using a mass spectrometry-based assay, we demonstrate a role for PI acyl group chains in regulating both the priming and activation steps of the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in mouse macrophages. In response to NLRP3 stimuli, cells deficient in ABC transporter ATP Binding Cassette Subfamily B Member 1 (ABCB1), which effluxes lipid derivatives, revealed defective inflammasome activation. Mechanistically, Abcb1 deficiency shifted the total PI configuration exhibiting a reduced ratio of short-chain to long-chain PI acyl lipids. Consequently, Abcb1 deficiency initiated the rapid degradation of Toll/IL-1R domain-containing adaptor protein, the TLR adaptor protein that binds PI (4,5)-bisphosphate, resulting in defective TLR-dependent signaling, and thus NLRP3 expression. Moreover, this accompanied increased NLRP3 phosphorylation at the Ser291 position and contributed to blunted inflammasome activation. Exogenously supplementing wild-type cells with linoleic acid (LA), but not arachidonic acid, reconfigured PI acyl chains. Accordingly, LA supplementation increased Toll/IL-1R domain-containing adaptor protein degradation, elevated NLRP3 phosphorylation, and abrogated inflammasome activation. Furthermore, NLRP3 Ser291 phosphorylation was dependent on PGE2-induced protein kinase A signaling because pharmacological inhibition of this pathway in LA-enriched cells dephosphorylated NLRP3. Altogether, our study reveals, to our knowledge, a novel metabolic-inflammatory circuit that contributes to calibrating immune responses." @default.
• W4293491624 created "2022-08-29" @default.
• W4293491624 creator A5023862478 @default.
• W4293491624 creator A5025141902 @default.
• W4293491624 creator A5028788909 @default.
• W4293491624 creator A5033171385 @default.
• W4293491624 creator A5040321582 @default.
• W4293491624 creator A5062357072 @default.
• W4293491624 creator A5073519687 @default.
• W4293491624 date "2022-08-01" @default.
• W4293491624 modified "2023-10-16" @default.
• W4293491624 title "NLRP3 Inflammasome Priming and Activation Are Regulated by a Phosphatidylinositol-Dependent Mechanism" @default.
• W4293491624 cites W1643436907 @default.
• W4293491624 cites W1882905539 @default.
• W4293491624 cites W1990584581 @default.
• W4293491624 cites W1993223367 @default.
• W4293491624 cites W1998010726 @default.
• W4293491624 cites W2000134546 @default.
• W4293491624 cites W2003372992 @default.
• W4293491624 cites W2005410446 @default.
• W4293491624 cites W2008225995 @default.
• W4293491624 cites W2015347323 @default.
• W4293491624 cites W2015665561 @default.
• W4293491624 cites W2020946741 @default.
• W4293491624 cites W2027732533 @default.
• W4293491624 cites W2033023829 @default.
• W4293491624 cites W2034763496 @default.
• W4293491624 cites W2039582913 @default.
• W4293491624 cites W2043823247 @default.
• W4293491624 cites W2065031087 @default.
• W4293491624 cites W2065609114 @default.
• W4293491624 cites W2076236539 @default.
• W4293491624 cites W2100599619 @default.
• W4293491624 cites W2125872855 @default.
• W4293491624 cites W2142205219 @default.
• W4293491624 cites W2144563590 @default.
• W4293491624 cites W2146544786 @default.
• W4293491624 cites W2154843786 @default.
• W4293491624 cites W2312601304 @default.
• W4293491624 cites W2326182425 @default.
• W4293491624 cites W2466539945 @default.
• W4293491624 cites W2472306545 @default.
• W4293491624 cites W2515507285 @default.
• W4293491624 cites W2516960518 @default.
• W4293491624 cites W2587680026 @default.
• W4293491624 cites W2589751962 @default.
• W4293491624 cites W2593398334 @default.
• W4293491624 cites W2604547648 @default.
• W4293491624 cites W2611459561 @default.
• W4293491624 cites W2787704745 @default.
• W4293491624 cites W2807905526 @default.
• W4293491624 cites W2884888151 @default.
• W4293491624 cites W2897547577 @default.
• W4293491624 cites W2902713146 @default.
• W4293491624 cites W2908733085 @default.
• W4293491624 cites W2942754201 @default.
• W4293491624 cites W2945779906 @default.
• W4293491624 cites W2948631155 @default.
• W4293491624 cites W2953206160 @default.
• W4293491624 cites W2981565897 @default.
• W4293491624 cites W3036545863 @default.
• W4293491624 cites W3087793031 @default.
• W4293491624 cites W4252021281 @default.
• W4293491624 doi "https://doi.org/10.4049/immunohorizons.2200058" @default.
• W4293491624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36038196" @default.
• W4293491624 hasPublicationYear "2022" @default.
• W4293491624 type Work @default.
• W4293491624 citedByCount "0" @default.
• W4293491624 crossrefType "journal-article" @default.
• W4293491624 hasAuthorship W4293491624A5023862478 @default.
• W4293491624 hasAuthorship W4293491624A5025141902 @default.
• W4293491624 hasAuthorship W4293491624A5028788909 @default.
• W4293491624 hasAuthorship W4293491624A5033171385 @default.
• W4293491624 hasAuthorship W4293491624A5040321582 @default.
• W4293491624 hasAuthorship W4293491624A5062357072 @default.
• W4293491624 hasAuthorship W4293491624A5073519687 @default.
• W4293491624 hasBestOaLocation W42934916241 @default.
• W4293491624 hasConcept C11960822 @default.
• W4293491624 hasConcept C136449434 @default.
• W4293491624 hasConcept C139174496 @default.
• W4293491624 hasConcept C170493617 @default.
• W4293491624 hasConcept C180899940 @default.
• W4293491624 hasConcept C183786373 @default.
• W4293491624 hasConcept C185592680 @default.
• W4293491624 hasConcept C2776909261 @default.
• W4293491624 hasConcept C2777209026 @default.
• W4293491624 hasConcept C2778918659 @default.
• W4293491624 hasConcept C2780610907 @default.
• W4293491624 hasConcept C41625074 @default.
• W4293491624 hasConcept C55493867 @default.
• W4293491624 hasConcept C62478195 @default.
• W4293491624 hasConcept C86803240 @default.
• W4293491624 hasConcept C95444343 @default.
• W4293491624 hasConceptScore W4293491624C11960822 @default.
• W4293491624 hasConceptScore W4293491624C136449434 @default.
• W4293491624 hasConceptScore W4293491624C139174496 @default.
• W4293491624 hasConceptScore W4293491624C170493617 @default.
• W4293491624 hasConceptScore W4293491624C180899940 @default.

• next