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• W4293492522 abstract "Objective To establish the most effective and best tolerated dose of caffeine citrate for the prevention of intermittent hypoxaemia (IH) in late preterm infants. Design Phase IIB, double-blind, five-arm, parallel, randomised controlled trial. Setting Neonatal units and postnatal wards of two tertiary maternity hospitals in New Zealand. Participants Late preterm infants born at 34 +0 –36 +6 weeks’ gestation, recruited within 72 hours of birth. Intervention Infants were randomly assigned to receive a loading dose (10, 20, 30 or 40 mg/kg) followed by 5, 10, 15 or 20 mg/kg/day equivolume enteral caffeine citrate or placebo daily until term corrected age. Primary outcome IH (events/hour with oxygen saturation concentration ≥10% below baseline for ≤2 min), 2 weeks postrandomisation. Results 132 infants with mean (SD) birth weight 2561 (481) g and gestational age 35.7 (0.8) weeks were randomised (24–28 per group). Caffeine reduced the rate of IH at 2 weeks postrandomisation (geometric mean (GM): 4.6, 4.6, 2.0, 3.8 and 1.7 events/hour for placebo, 5, 10, 15 and 20 mg/kg/day, respectively), with differences statistically significant for 10 mg/kg/day (GM ratio (95% CI] 0.39 (0.20 to 0.76]; p=0.006) and 20 mg/kg/day (GM ratio (95% CI] 0.33 (0.17 to 0.68]; p=0.003) compared with placebo. The 20 mg/kg/day dose increased mean (SD) pulse oximetry oxygen saturation (SpO 2 ) (97.2 (1.0) vs placebo 96.0 (0.8); p<0.001), and reduced median (IQR) percentage of time SpO 2 <90% (0.5 (0.2–0.8) vs 1.1 (0.6–2.4); p<0.001) at 2 weeks, without significant adverse effects on growth velocity or sleeping. Conclusion Caffeine reduces IH in late preterm infants at 2 weeks of age, with 20 mg/kg/day being the most effective dose. Trial registration number ACTRN12618001745235." @default.
• W4293492522 created "2022-08-29" @default.
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• W4293492522 date "2022-08-29" @default.
• W4293492522 modified "2023-10-15" @default.
• W4293492522 title "Caffeine to prevent intermittent hypoxaemia in late preterm infants: randomised controlled dosage trial" @default.
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• W4293492522 doi "https://doi.org/10.1136/archdischild-2022-324010" @default.
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