Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293492979> ?p ?o ?g. }
- W4293492979 endingPage "11839" @default.
- W4293492979 startingPage "11818" @default.
- W4293492979 abstract "The critical pathogenesis of type 1 diabetes (T1D)/type 2 diabetes (T2D) is the physical status, mass, and function of pancreatic β cells. Mammalian STE20-like protein 1 kinase (MST1) plays vital roles in the apoptosis and insulin secretion of β cells. Here, we discovered a novel, potent, and selective MST1 inhibitor 19 (IC50 = 23 nM), which inhibited the phosphorylation of MST1-protected β cells from the damage of inflammatory cytokines in vitro. In vivo, it displayed acceptable pharmacokinetic properties in different species. In the STZ-induced T1D/T2D mouse models, both monotherapy of 19 and in combination with metformin led to the decline of fasting blood glucose and showed protective effect of β cells. In addition, the combination of 19 and metformin decreased the hemoglobin A1c level. Together, our study suggested that 19 might be a useful pharmacological tool to study MST1-mediated physiology and pathology as well as a potential drug candidate for diabetes." @default.
- W4293492979 created "2022-08-29" @default.
- W4293492979 creator A5000728648 @default.
- W4293492979 creator A5009717743 @default.
- W4293492979 creator A5012278873 @default.
- W4293492979 creator A5029503387 @default.
- W4293492979 creator A5029764295 @default.
- W4293492979 creator A5033998326 @default.
- W4293492979 creator A5036430123 @default.
- W4293492979 creator A5044277554 @default.
- W4293492979 creator A5048989648 @default.
- W4293492979 creator A5054794579 @default.
- W4293492979 creator A5056391726 @default.
- W4293492979 creator A5058484759 @default.
- W4293492979 creator A5058944345 @default.
- W4293492979 creator A5062755510 @default.
- W4293492979 creator A5064773330 @default.
- W4293492979 creator A5069044551 @default.
- W4293492979 creator A5075949263 @default.
- W4293492979 date "2022-08-29" @default.
- W4293492979 modified "2023-10-16" @default.
- W4293492979 title "Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 Diabetes" @default.
- W4293492979 cites W1974762803 @default.
- W4293492979 cites W2014582878 @default.
- W4293492979 cites W2062059848 @default.
- W4293492979 cites W2076943958 @default.
- W4293492979 cites W2105668062 @default.
- W4293492979 cites W2107866321 @default.
- W4293492979 cites W2109904224 @default.
- W4293492979 cites W2120646148 @default.
- W4293492979 cites W2148147368 @default.
- W4293492979 cites W2157504181 @default.
- W4293492979 cites W2158035115 @default.
- W4293492979 cites W2164469233 @default.
- W4293492979 cites W2167096785 @default.
- W4293492979 cites W2512544075 @default.
- W4293492979 cites W2781367792 @default.
- W4293492979 cites W2806728017 @default.
- W4293492979 cites W2898202023 @default.
- W4293492979 cites W2911745815 @default.
- W4293492979 cites W2987638675 @default.
- W4293492979 cites W3011723741 @default.
- W4293492979 cites W3088022081 @default.
- W4293492979 cites W3095288335 @default.
- W4293492979 cites W3123671769 @default.
- W4293492979 cites W3189949217 @default.
- W4293492979 doi "https://doi.org/10.1021/acs.jmedchem.2c00926" @default.
- W4293492979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36037148" @default.
- W4293492979 hasPublicationYear "2022" @default.
- W4293492979 type Work @default.
- W4293492979 citedByCount "2" @default.
- W4293492979 countsByYear W42934929792023 @default.
- W4293492979 crossrefType "journal-article" @default.
- W4293492979 hasAuthorship W4293492979A5000728648 @default.
- W4293492979 hasAuthorship W4293492979A5009717743 @default.
- W4293492979 hasAuthorship W4293492979A5012278873 @default.
- W4293492979 hasAuthorship W4293492979A5029503387 @default.
- W4293492979 hasAuthorship W4293492979A5029764295 @default.
- W4293492979 hasAuthorship W4293492979A5033998326 @default.
- W4293492979 hasAuthorship W4293492979A5036430123 @default.
- W4293492979 hasAuthorship W4293492979A5044277554 @default.
- W4293492979 hasAuthorship W4293492979A5048989648 @default.
- W4293492979 hasAuthorship W4293492979A5054794579 @default.
- W4293492979 hasAuthorship W4293492979A5056391726 @default.
- W4293492979 hasAuthorship W4293492979A5058484759 @default.
- W4293492979 hasAuthorship W4293492979A5058944345 @default.
- W4293492979 hasAuthorship W4293492979A5062755510 @default.
- W4293492979 hasAuthorship W4293492979A5064773330 @default.
- W4293492979 hasAuthorship W4293492979A5069044551 @default.
- W4293492979 hasAuthorship W4293492979A5075949263 @default.
- W4293492979 hasConcept C126322002 @default.
- W4293492979 hasConcept C134018914 @default.
- W4293492979 hasConcept C150903083 @default.
- W4293492979 hasConcept C185592680 @default.
- W4293492979 hasConcept C190283241 @default.
- W4293492979 hasConcept C202751555 @default.
- W4293492979 hasConcept C207001950 @default.
- W4293492979 hasConcept C2777180221 @default.
- W4293492979 hasConcept C2777752497 @default.
- W4293492979 hasConcept C2779306644 @default.
- W4293492979 hasConcept C2780035454 @default.
- W4293492979 hasConcept C2780323712 @default.
- W4293492979 hasConcept C2781232474 @default.
- W4293492979 hasConcept C502942594 @default.
- W4293492979 hasConcept C55493867 @default.
- W4293492979 hasConcept C555293320 @default.
- W4293492979 hasConcept C71924100 @default.
- W4293492979 hasConcept C86803240 @default.
- W4293492979 hasConcept C98274493 @default.
- W4293492979 hasConceptScore W4293492979C126322002 @default.
- W4293492979 hasConceptScore W4293492979C134018914 @default.
- W4293492979 hasConceptScore W4293492979C150903083 @default.
- W4293492979 hasConceptScore W4293492979C185592680 @default.
- W4293492979 hasConceptScore W4293492979C190283241 @default.
- W4293492979 hasConceptScore W4293492979C202751555 @default.
- W4293492979 hasConceptScore W4293492979C207001950 @default.
- W4293492979 hasConceptScore W4293492979C2777180221 @default.
- W4293492979 hasConceptScore W4293492979C2777752497 @default.