FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293493666> ?p ?o ?g. }

• W4293493666 abstract "Alzheimer´s disease (AD), the most common form of dementia in industrialized countries, severely targets the hippocampal formation in humans and mouse models of this condition. The adult hippocampus hosts the continuous addition of new dentate granule cells (DGCs) in numerous mammalian species, including humans. Although the morphology and positioning of DGCs within the granule cell layer (GCL) match their developmental origin in rodents, a similar correlation has not been reported in humans to date. Our data reveal that DGCs located in inner portions of the human GCL show shorter and less complex dendrites than those found in outer portions of this layer, which are presumably generated developmentally. Moreover, in AD patients, DGCs show early morphological alterations that are further aggravated as the disease progresses. An aberrantly increased number of DGCs with several primary apical dendrites is the first morphological change detected in patients at Braak-Tau I/II stages. This alteration persists throughout AD progression and leads to generalized dendritic atrophy at late stages of the disease. Our data reveal the distinct vulnerability of several morphological characteristics of DGCs located in the inner and outer portions of the GCL to AD and support the notion that the malfunction of the hippocampus is related to cognitive impairments in patients with AD." @default.
• W4293493666 created "2022-08-29" @default.
• W4293493666 creator A5003915764 @default.
• W4293493666 creator A5068800327 @default.
• W4293493666 creator A5080613664 @default.
• W4293493666 date "2022-08-29" @default.
• W4293493666 modified "2023-10-17" @default.
• W4293493666 title "Progression of Alzheimer's disease parallels unusual structural plasticity of human dentate granule cells" @default.
• W4293493666 cites W1515328725 @default.
• W4293493666 cites W1556113948 @default.
• W4293493666 cites W1582546938 @default.
• W4293493666 cites W1919353 @default.
• W4293493666 cites W1971640012 @default.
• W4293493666 cites W1985033427 @default.
• W4293493666 cites W1997355517 @default.
• W4293493666 cites W2001621281 @default.
• W4293493666 cites W2002112050 @default.
• W4293493666 cites W2015001118 @default.
• W4293493666 cites W2016153276 @default.
• W4293493666 cites W2022523348 @default.
• W4293493666 cites W2025804381 @default.
• W4293493666 cites W2028683459 @default.
• W4293493666 cites W2032928022 @default.
• W4293493666 cites W2035158911 @default.
• W4293493666 cites W2037846982 @default.
• W4293493666 cites W2046148144 @default.
• W4293493666 cites W2067856703 @default.
• W4293493666 cites W2085182512 @default.
• W4293493666 cites W2093650784 @default.
• W4293493666 cites W2098371930 @default.
• W4293493666 cites W2121418448 @default.
• W4293493666 cites W2126974689 @default.
• W4293493666 cites W2138878035 @default.
• W4293493666 cites W2139828814 @default.
• W4293493666 cites W2140493425 @default.
• W4293493666 cites W2159838014 @default.
• W4293493666 cites W2262093733 @default.
• W4293493666 cites W2374804331 @default.
• W4293493666 cites W2529680063 @default.
• W4293493666 cites W2532943904 @default.
• W4293493666 cites W2772689998 @default.
• W4293493666 cites W2775536261 @default.
• W4293493666 cites W2890879880 @default.
• W4293493666 cites W2925056974 @default.
• W4293493666 cites W2945693197 @default.
• W4293493666 cites W2947135947 @default.
• W4293493666 cites W2999135595 @default.
• W4293493666 cites W3004934488 @default.
• W4293493666 cites W3009584276 @default.
• W4293493666 cites W3036638316 @default.
• W4293493666 cites W3101899421 @default.
• W4293493666 cites W3161561112 @default.
• W4293493666 cites W3205950297 @default.
• W4293493666 cites W4236882906 @default.
• W4293493666 cites W4283364953 @default.
• W4293493666 doi "https://doi.org/10.1186/s40478-022-01431-7" @default.
• W4293493666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36038918" @default.
• W4293493666 hasPublicationYear "2022" @default.
• W4293493666 type Work @default.
• W4293493666 citedByCount "6" @default.
• W4293493666 countsByYear W42934936662023 @default.
• W4293493666 crossrefType "journal-article" @default.
• W4293493666 hasAuthorship W4293493666A5003915764 @default.
• W4293493666 hasAuthorship W4293493666A5068800327 @default.
• W4293493666 hasAuthorship W4293493666A5080613664 @default.
• W4293493666 hasBestOaLocation W42934936661 @default.
• W4293493666 hasConcept C142724271 @default.
• W4293493666 hasConcept C148762608 @default.
• W4293493666 hasConcept C151730666 @default.
• W4293493666 hasConcept C169760540 @default.
• W4293493666 hasConcept C2776464000 @default.
• W4293493666 hasConcept C2778888523 @default.
• W4293493666 hasConcept C2779134260 @default.
• W4293493666 hasConcept C2779483572 @default.
• W4293493666 hasConcept C2781161787 @default.
• W4293493666 hasConcept C2781172350 @default.
• W4293493666 hasConcept C2984863031 @default.
• W4293493666 hasConcept C49760210 @default.
• W4293493666 hasConcept C502032728 @default.
• W4293493666 hasConcept C71924100 @default.
• W4293493666 hasConcept C86803240 @default.
• W4293493666 hasConceptScore W4293493666C142724271 @default.
• W4293493666 hasConceptScore W4293493666C148762608 @default.
• W4293493666 hasConceptScore W4293493666C151730666 @default.
• W4293493666 hasConceptScore W4293493666C169760540 @default.
• W4293493666 hasConceptScore W4293493666C2776464000 @default.
• W4293493666 hasConceptScore W4293493666C2778888523 @default.
• W4293493666 hasConceptScore W4293493666C2779134260 @default.
• W4293493666 hasConceptScore W4293493666C2779483572 @default.
• W4293493666 hasConceptScore W4293493666C2781161787 @default.
• W4293493666 hasConceptScore W4293493666C2781172350 @default.
• W4293493666 hasConceptScore W4293493666C2984863031 @default.
• W4293493666 hasConceptScore W4293493666C49760210 @default.
• W4293493666 hasConceptScore W4293493666C502032728 @default.
• W4293493666 hasConceptScore W4293493666C71924100 @default.
• W4293493666 hasConceptScore W4293493666C86803240 @default.
• W4293493666 hasFunder F4320306219 @default.
• W4293493666 hasFunder F4320307532 @default.
• W4293493666 hasFunder F4320310209 @default.
• W4293493666 hasFunder F4320310214 @default.

• next