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- W4293493786 abstract "Abstract Exercise including locomotion requires appropriate autonomic cardiovascular adjustments to meet the metabolic demands of contracting muscles, yet the functional brain architecture underlying these adjustments remains unknown. Here, we demonstrate brainstem circuitry that plays an essential role in relaying volitional motor signals, i.e., central command, to drive locomotor activities and sympathetic cardiovascular responses. Mesencephalic locomotor neurons in rats transmit central command-driven excitatory signals onto the rostral ventrolateral medulla at least partially via glutamatergic processes, to activate both somatomotor and sympathetic nervous systems. Optogenetic excitation of this monosynaptic pathway elicits locomotor and cardiovascular responses as seen during running exercise, whereas pathway inhibition suppresses the locomotor activities and blood pressure elevation during voluntary running without affecting basal cardiovascular homeostasis. These results demonstrate an important subcortical pathway that transmits central command signals, providing a key insight into the central circuit mechanism required for the physiological conditioning essential to maximize exercise performance." @default.
- W4293493786 created "2022-08-29" @default.
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- W4293493786 date "2022-08-29" @default.
- W4293493786 modified "2023-10-18" @default.
- W4293493786 title "A brainstem monosynaptic excitatory pathway that drives locomotor activities and sympathetic cardiovascular responses" @default.
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- W4293493786 doi "https://doi.org/10.1038/s41467-022-32823-x" @default.
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