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• W4293493815 abstract "Abstract Glaucoma is a chronic neurological condition that causes damage to retinal ganglion cells and nerve fibres. The transforming growth factor pathway may have a role in disease progression, but its mechanism and regulation are unknown. We explored the molecular mechanisms behind glaucoma onset and progression utilising a network and systems biology approach. First, we manually curated a glaucoma-related seed network. Simulation results reveal increasing BMP gene expression, EMC production, and gene transcription regulation. When glaucoma and control data are compared, gene expression analysis reveals that 21 of these 40 genes are downregulated, and 19 are upregulated. HLA-DPA1, COL3A1, TGFB3, LEFTY2, and ARHGEF6 are the most important genes that were upregulated, while RGMA, GADD45B, LAMMB3, ZFP36, and CEBPD are the most important genes that were downregulated. The miRNA target prediction and their expression studies revealed 37 miRNA targets, including 13 miRNA targets that were downregulated and 15 that were upregulated. For the regulation of gene expression, 7 transcription factors, including STAT3, ZNF263, NR3C1, CTCF, TCF4, FOS, and EGR1, have been revealed to regulate more than 2 DEGs genes. We further analysed the drug availability; 41 drugs for 14 gene targets and 1032 compounds for ten gene targets have been identified from the drug bank and ChEMBL for the novel targets. Furthermore, we identified BP words most significantly associated with the extracellular matrix, SMAD protein signal, and BMP signalling pathway. The preferred gene-affecting pathway that includes MAPK, TGF-beta, and other cancer-related pathways was discovered. The involvement of TGF in the development of glaucoma may be studied to shed new light on therapeutic targets and discover new drugs to target disease progression" @default.
• W4293493815 created "2022-08-29" @default.
• W4293493815 creator A5039528181 @default.
• W4293493815 creator A5072284282 @default.
• W4293493815 date "2022-08-29" @default.
• W4293493815 modified "2023-09-26" @default.
• W4293493815 title "Regulation of BMP genes, EMC production and deposition through TGFβ/Smad Signaling in Human Trabecular Meshwork for progression of glaucoma disease" @default.
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• W4293493815 doi "https://doi.org/10.21203/rs.3.rs-1969317/v1" @default.
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