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- W4293495696 abstract "Abstract Neuroinflammation contributes to the progression of cerebral ischemia/reperfusion (I/R) damage. Scutellarin (SL) is a glucuronide flavonoid that has apoptotic, anti‐inflammatory, and anti‐tumor properties. It is anti‐oxidant and anti‐inflammatory mechanism as a neuroprotective against ischemic brain injury is unknown. The purpose of the study was to examine the role and mechanism of SL in preventing I/R damage in a rat model. SL (40 and 80 mg/kg) was given to the rats for 14 days before the ischemic stroke. SL administration prevented I/R mediated brain injury, and neuronal apoptosis. Malondialdehyde, superoxide dismutase, glutathione, IL‐6, and IL‐1β and nitric oxide were modulated by SL. SL suppressed the p65 and p38 expressions in particular. The findings show that SL protects rats from cerebral damage caused by I/R through the nuclear factor kappa‐B p65 and p38 mitogen‐activated protein kinase signaling pathway. Thus, SL protected the brain of rats from ischemic injury by inhibiting the inflammatory process." @default.
- W4293495696 created "2022-08-29" @default.
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- W4293495696 date "2022-08-29" @default.
- W4293495696 modified "2023-10-16" @default.
- W4293495696 title "Scutellarin alleviates cerebral ischemia/reperfusion by suppressing oxidative stress and inflammatory responses via <scp>MAPK</scp>/<scp>NF‐κB</scp> pathways in rats" @default.
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- W4293495696 doi "https://doi.org/10.1002/tox.23645" @default.
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