FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293510396> ?p ?o ?g. }

• W4293510396 endingPage "2041" @default.
• W4293510396 startingPage "2030" @default.
• W4293510396 abstract "Background Clinical complexity is common in atrial fibrillation (AF) patients. We assessed the impact of clinical complexity on oral anticoagulant (OAC) treatment patterns and major adverse outcomes in a contemporary cohort of AF patients. Methods The GLORIA-AF Phase II and III Registry enrolled newly diagnosed AF patients with at least one stroke risk factor. Among patients with CHA2DS2-VASc score ≥2, we defined four domains of perceived clinical complexity: frail elderly (age ≥75 years and body mass index <23 kg/m2), chronic kidney disease (CKD, creatinine clearance <60 mL/min), history of bleeding, and those with ≥2 of the above conditions. We evaluated the associations between clinical complexity domains and antithrombotic treatment prescription, risk of OAC discontinuation, and major adverse outcomes. Results Among the 29,625 patients included (mean age 69.6 ± 10.7 years, 44.2% females), 9,504 (32.1%) presented with at least one complexity criterion. Clinical complexity was associated with lower OAC prescription, with stronger associations in frail elderly (odds ratio [OR]: 0.47, 95% confidence interval [CI]: 0.36–0.62) and those with ≥2 complexity domains (OR: 0.50, 95% CI: 0.44–0.57). Risk of OAC discontinuation was higher among frail elderly (hazard ratio [HR]: 1.30, 95% CI: 1.00–1.69), CKD (HR: 1.10, 95% CI: 1.02–1.20), and those with ≥2 complexity domains (HR: 1.39, 95% CI: 1.23–1.57). Clinical complexity was associated with higher risk of the primary outcome of all-cause death, thromboembolism, and major bleeding, with the highest magnitude in those with ≥2 criteria (HR: 1.63, 95% CI: 1.43–1.86). Conclusion In AF patients, clinical complexity influences OAC treatment management, and increases the risk of poor clinical outcomes. These patients require additional efforts, such as integrated care approach, to improve their management and prognosis." @default.
• W4293510396 created "2022-08-30" @default.
• W4293510396 creator A5026613773 @default.
• W4293510396 creator A5035512968 @default.
• W4293510396 creator A5037996012 @default.
• W4293510396 creator A5048738698 @default.
• W4293510396 creator A5052514318 @default.
• W4293510396 creator A5073273792 @default.
• W4293510396 creator A5088579117 @default.
• W4293510396 date "2022-08-29" @default.
• W4293510396 modified "2023-10-17" @default.
• W4293510396 title "Clinical Complexity Domains, Anticoagulation, and Outcomes in Patients with Atrial Fibrillation: A Report from the GLORIA-AF Registry Phase II and III" @default.
• W4293510396 cites W1973320886 @default.
• W4293510396 cites W2054077136 @default.
• W4293510396 cites W2120919020 @default.
• W4293510396 cites W2130163055 @default.
• W4293510396 cites W2141347595 @default.
• W4293510396 cites W2159975225 @default.
• W4293510396 cites W2175794335 @default.
• W4293510396 cites W2747485523 @default.
• W4293510396 cites W2754840680 @default.
• W4293510396 cites W2756618065 @default.
• W4293510396 cites W2769275060 @default.
• W4293510396 cites W2780840915 @default.
• W4293510396 cites W2804987717 @default.
• W4293510396 cites W2888617602 @default.
• W4293510396 cites W2901264117 @default.
• W4293510396 cites W2924424410 @default.
• W4293510396 cites W2936323777 @default.
• W4293510396 cites W2982223480 @default.
• W4293510396 cites W2993267366 @default.
• W4293510396 cites W2996784933 @default.
• W4293510396 cites W3011175941 @default.
• W4293510396 cites W3012307018 @default.
• W4293510396 cites W3013924214 @default.
• W4293510396 cites W3022127313 @default.
• W4293510396 cites W3080759903 @default.
• W4293510396 cites W3082001974 @default.
• W4293510396 cites W3082188176 @default.
• W4293510396 cites W3084099607 @default.
• W4293510396 cites W3094823953 @default.
• W4293510396 cites W3115199228 @default.
• W4293510396 cites W3125380182 @default.
• W4293510396 cites W3163372954 @default.
• W4293510396 cites W3205588752 @default.
• W4293510396 cites W3214524979 @default.
• W4293510396 cites W4200044943 @default.
• W4293510396 cites W4200054776 @default.
• W4293510396 cites W4205113539 @default.
• W4293510396 cites W4220912280 @default.
• W4293510396 cites W4220929034 @default.
• W4293510396 cites W4221050267 @default.
• W4293510396 cites W4223439574 @default.
• W4293510396 cites W4225157644 @default.
• W4293510396 cites W4226057689 @default.
• W4293510396 cites W4281775000 @default.
• W4293510396 doi "https://doi.org/10.1055/s-0042-1756355" @default.
• W4293510396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36037828" @default.
• W4293510396 hasPublicationYear "2022" @default.
• W4293510396 type Work @default.
• W4293510396 citedByCount "20" @default.
• W4293510396 countsByYear W42935103962022 @default.
• W4293510396 countsByYear W42935103962023 @default.
• W4293510396 crossrefType "journal-article" @default.
• W4293510396 hasAuthorship W4293510396A5026613773 @default.
• W4293510396 hasAuthorship W4293510396A5035512968 @default.
• W4293510396 hasAuthorship W4293510396A5037996012 @default.
• W4293510396 hasAuthorship W4293510396A5048738698 @default.
• W4293510396 hasAuthorship W4293510396A5052514318 @default.
• W4293510396 hasAuthorship W4293510396A5073273792 @default.
• W4293510396 hasAuthorship W4293510396A5088579117 @default.
• W4293510396 hasBestOaLocation W42935103961 @default.
• W4293510396 hasConcept C126322002 @default.
• W4293510396 hasConcept C127413603 @default.
• W4293510396 hasConcept C156957248 @default.
• W4293510396 hasConcept C197934379 @default.
• W4293510396 hasConcept C207103383 @default.
• W4293510396 hasConcept C2778653478 @default.
• W4293510396 hasConcept C2778715236 @default.
• W4293510396 hasConcept C2779161974 @default.
• W4293510396 hasConcept C2780221984 @default.
• W4293510396 hasConcept C2780645631 @default.
• W4293510396 hasConcept C44249647 @default.
• W4293510396 hasConcept C71924100 @default.
• W4293510396 hasConcept C78519656 @default.
• W4293510396 hasConceptScore W4293510396C126322002 @default.
• W4293510396 hasConceptScore W4293510396C127413603 @default.
• W4293510396 hasConceptScore W4293510396C156957248 @default.
• W4293510396 hasConceptScore W4293510396C197934379 @default.
• W4293510396 hasConceptScore W4293510396C207103383 @default.
• W4293510396 hasConceptScore W4293510396C2778653478 @default.
• W4293510396 hasConceptScore W4293510396C2778715236 @default.
• W4293510396 hasConceptScore W4293510396C2779161974 @default.
• W4293510396 hasConceptScore W4293510396C2780221984 @default.
• W4293510396 hasConceptScore W4293510396C2780645631 @default.
• W4293510396 hasConceptScore W4293510396C44249647 @default.
• W4293510396 hasConceptScore W4293510396C71924100 @default.
• W4293510396 hasConceptScore W4293510396C78519656 @default.

• next