FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293514279> ?p ?o ?g. }

• W4293514279 endingPage "1659" @default.
• W4293514279 startingPage "1659" @default.
• W4293514279 abstract "Intensive research has focused on minimizing the infarct area and stimulating endogenous regeneration after myocardial infarction. Our group previously elucidated that apicidin, a histone deacetylase (HDAC) inhibitor, robustly accelerates the cardiac commitment of naïve mesenchymal stem cells (MSCs) through acute loss of YAP1. Here, we propose the novel regulation of YAP1 in MSCs. We found that acute loss of YAP1 after apicidin treatment resulted in the mixed effects of transcriptional arrest and proteasomal degradation. Subcellular fractionation revealed that YAP1 was primarily localized in the cytoplasm. YAP1 was acutely relocalized into the nucleus and underwent proteasomal degradation. Interestingly, phosphor-S127 YAP1 was shuttled into the nucleus, suggesting that a mechanism other than phosphorylation governed the subcellular localization of YAP1. Apicidin successfully induced acetylation and subsequent dissociation of YAP1 from 14-3-3, an essential molecule for cytoplasmic restriction. HDAC6 regulated both acetylation and subcellular localization of YAP1. An acetylation-dead mutant of YAP1 retarded nuclear redistribution upon apicidin treatment. We failed to acquire convincing evidence for polyubiquitination-dependent degradation of YAP1, suggesting that a polyubiquitination-independent regulator determined YAP1 fate. Nuclear PSME4, a subunit of the 26 S proteasome, recognized and degraded acetyl YAP1 in the nucleus. MSCs from PSME4-null mice were injected into infarcted heart, and aberrant sudden death was observed. Injection of immortalized human MSCs after knocking down PSME4 failed to improve either cardiac function or the fibrotic scar area. Our data suggest that acetylation-dependent proteasome subunit PSME4 clears acetyl-YAP1 in response to apicidin treatment in the nucleus of MSCs." @default.
• W4293514279 created "2022-08-30" @default.
• W4293514279 creator A5000756919 @default.
• W4293514279 creator A5003969390 @default.
• W4293514279 creator A5020551765 @default.
• W4293514279 creator A5034147174 @default.
• W4293514279 creator A5050000739 @default.
• W4293514279 creator A5051260703 @default.
• W4293514279 creator A5053222940 @default.
• W4293514279 creator A5058600119 @default.
• W4293514279 creator A5059808816 @default.
• W4293514279 creator A5067349782 @default.
• W4293514279 creator A5075329848 @default.
• W4293514279 date "2022-08-09" @default.
• W4293514279 modified "2023-09-26" @default.
• W4293514279 title "PSME4 Degrades Acetylated YAP1 in the Nucleus of Mesenchymal Stem Cells" @default.
• W4293514279 cites W1534598827 @default.
• W4293514279 cites W1974065358 @default.
• W4293514279 cites W1984807833 @default.
• W4293514279 cites W1995286643 @default.
• W4293514279 cites W1996070102 @default.
• W4293514279 cites W2001419407 @default.
• W4293514279 cites W2003996125 @default.
• W4293514279 cites W2009682316 @default.
• W4293514279 cites W2023577211 @default.
• W4293514279 cites W2026216248 @default.
• W4293514279 cites W2030028037 @default.
• W4293514279 cites W2035127869 @default.
• W4293514279 cites W2035904396 @default.
• W4293514279 cites W2048665583 @default.
• W4293514279 cites W2054847560 @default.
• W4293514279 cites W2056510698 @default.
• W4293514279 cites W2063078660 @default.
• W4293514279 cites W2063601357 @default.
• W4293514279 cites W2068614944 @default.
• W4293514279 cites W2099709490 @default.
• W4293514279 cites W2103227058 @default.
• W4293514279 cites W2108246093 @default.
• W4293514279 cites W2116276334 @default.
• W4293514279 cites W2123771262 @default.
• W4293514279 cites W2124059822 @default.
• W4293514279 cites W2129466238 @default.
• W4293514279 cites W2130794824 @default.
• W4293514279 cites W2131388270 @default.
• W4293514279 cites W2134937820 @default.
• W4293514279 cites W2140381750 @default.
• W4293514279 cites W2159376228 @default.
• W4293514279 cites W2196906371 @default.
• W4293514279 cites W2521650734 @default.
• W4293514279 cites W2564731431 @default.
• W4293514279 cites W2609111976 @default.
• W4293514279 cites W2612678024 @default.
• W4293514279 cites W2758030386 @default.
• W4293514279 cites W2786389763 @default.
• W4293514279 cites W2806451720 @default.
• W4293514279 cites W2810370219 @default.
• W4293514279 cites W2910500300 @default.
• W4293514279 cites W2950071764 @default.
• W4293514279 cites W2969772586 @default.
• W4293514279 cites W3022386151 @default.
• W4293514279 cites W3036745223 @default.
• W4293514279 cites W3091295206 @default.
• W4293514279 cites W3095930618 @default.
• W4293514279 cites W3109606315 @default.
• W4293514279 cites W3119359192 @default.
• W4293514279 cites W3197713785 @default.
• W4293514279 cites W4225597907 @default.
• W4293514279 doi "https://doi.org/10.3390/pharmaceutics14081659" @default.
• W4293514279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36015285" @default.
• W4293514279 hasPublicationYear "2022" @default.
• W4293514279 type Work @default.
• W4293514279 citedByCount "2" @default.
• W4293514279 countsByYear W42935142792022 @default.
• W4293514279 countsByYear W42935142792023 @default.
• W4293514279 crossrefType "journal-article" @default.
• W4293514279 hasAuthorship W4293514279A5000756919 @default.
• W4293514279 hasAuthorship W4293514279A5003969390 @default.
• W4293514279 hasAuthorship W4293514279A5020551765 @default.
• W4293514279 hasAuthorship W4293514279A5034147174 @default.
• W4293514279 hasAuthorship W4293514279A5050000739 @default.
• W4293514279 hasAuthorship W4293514279A5051260703 @default.
• W4293514279 hasAuthorship W4293514279A5053222940 @default.
• W4293514279 hasAuthorship W4293514279A5058600119 @default.
• W4293514279 hasAuthorship W4293514279A5059808816 @default.
• W4293514279 hasAuthorship W4293514279A5067349782 @default.
• W4293514279 hasAuthorship W4293514279A5075329848 @default.
• W4293514279 hasBestOaLocation W42935142791 @default.
• W4293514279 hasConcept C104317684 @default.
• W4293514279 hasConcept C119157956 @default.
• W4293514279 hasConcept C185592680 @default.
• W4293514279 hasConcept C190062978 @default.
• W4293514279 hasConcept C198826908 @default.
• W4293514279 hasConcept C27740335 @default.
• W4293514279 hasConcept C2776879804 @default.
• W4293514279 hasConcept C2780114586 @default.
• W4293514279 hasConcept C2780219982 @default.
• W4293514279 hasConcept C502942594 @default.
• W4293514279 hasConcept C54757728 @default.

• next