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- W4293516341 abstract "Receptor for hyaluronic acid-mediated motility (RHAMM) is a cell surface receptor for hyaluronic acid that is critical for cell migration and a cell cycle protein involved in microtubule assembly and stability. These functions of RHAMM are required for cellular stress responses and cell cycle progression but are also exploited by tumor cells for malignant progression and metastasis. RHAMM is often overexpressed in tumors and is an independent adverse prognostic factor for a number of cancers such as breast and prostate. Interestingly, pharmacological or genetic inhibition of RHAMM in vitro and in vivo ablates tumor invasiveness and metastatic spread, implicating RHAMM as a potential therapeutic target to restrict tumor growth and improve patient survival. However, RHAMM's pro-tumor activity is dependent on its subcellular distribution, which complicates the design of RHAMM-directed therapies. An alternative approach is to identify downstream signaling pathways that mediate RHAMM-promoted tumor aggressiveness. Herein, we discuss the pro-tumoral roles of RHAMM and elucidate the corresponding regulators and signaling pathways mediating RHAMM downstream events, with a specific focus on strategies to target the RHAMM signaling network in cancer cells." @default.
- W4293516341 created "2022-08-30" @default.
- W4293516341 creator A5050075947 @default.
- W4293516341 creator A5080276064 @default.
- W4293516341 creator A5081123662 @default.
- W4293516341 creator A5090961331 @default.
- W4293516341 creator A5091136224 @default.
- W4293516341 date "2022-08-10" @default.
- W4293516341 modified "2023-10-12" @default.
- W4293516341 title "The role of RHAMM in cancer: Exposing novel therapeutic vulnerabilities" @default.
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