FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293516718> ?p ?o ?g. }

• W4293516718 endingPage "3844" @default.
• W4293516718 startingPage "3844" @default.
• W4293516718 abstract "The optimal sequence of chemoradiotherapy with immunotherapy is still not established. The patient’s immune status may play a role in determining this order. We aim to determine the kinetics of a multi-potential haemopoietic factor FMS-related tyrosine kinase 3 ligand (Flt-3L) during chemoradiotherapy. Our pilot, a single arm prospective study, enrolled patients with rectal cancer who qualified for neoadjuvant chemoradiotherapy. Blood samples for Flt-3L were collected before and every second week of chemoradiotherapy for a complete blood count every week. The kinetics of Flt-3L were assessed using Friedman’s ANOVA. A multiple factor analysis (MFA) was performed to find relevant factors affecting levels of serum Flt-3L during chemoradiotherapy. FactoMineR and factoextra R packages were used for analysis. In the 33 patients enrolled, the level of Flt-3L increased from the second week and remained elevated until the end of treatment (p < 0.01). All patients experienced Grade ≥2 lymphopenia with a nadir detected mostly in the 5/6th week. MFA revealed the spatial partitioning of patients among the first and second dimensions (explained by 38.49% and 23.14% variance). The distribution along these dimensions represents the magnitude of early changes of Flt-3L. Patients with the lowest values of Flt-3L change showed the highest lymphocyte nadirs and lowest dose/volume parameters of active bone marrow. Our hypothesis-generating study supports the concept of early initiation of immuno-therapy when the concentration of Flt-3L is high and no lymphopenia has yet occurred." @default.
• W4293516718 created "2022-08-30" @default.
• W4293516718 creator A5004153994 @default.
• W4293516718 creator A5016219286 @default.
• W4293516718 creator A5017976754 @default.
• W4293516718 creator A5018456614 @default.
• W4293516718 creator A5035948170 @default.
• W4293516718 creator A5065498178 @default.
• W4293516718 creator A5073592253 @default.
• W4293516718 creator A5084554327 @default.
• W4293516718 date "2022-08-09" @default.
• W4293516718 modified "2023-09-26" @default.
• W4293516718 title "The Kinetics of FMS-Related Tyrosine Kinase 3 Ligand (Flt-3L) during Chemoradiotherapy Suggests a Potential Gain from the Earlier Initiation of Immunotherapy" @default.
• W4293516718 cites W1410010118 @default.
• W4293516718 cites W1978104069 @default.
• W4293516718 cites W1994826332 @default.
• W4293516718 cites W2002225209 @default.
• W4293516718 cites W2004207939 @default.
• W4293516718 cites W2031421412 @default.
• W4293516718 cites W2045804591 @default.
• W4293516718 cites W2051732555 @default.
• W4293516718 cites W2094013107 @default.
• W4293516718 cites W2116017558 @default.
• W4293516718 cites W2132413371 @default.
• W4293516718 cites W2153947402 @default.
• W4293516718 cites W2434730538 @default.
• W4293516718 cites W2582380144 @default.
• W4293516718 cites W2790775020 @default.
• W4293516718 cites W2791567488 @default.
• W4293516718 cites W2906764918 @default.
• W4293516718 cites W2970170486 @default.
• W4293516718 cites W2994243335 @default.
• W4293516718 cites W2994351223 @default.
• W4293516718 cites W3022765906 @default.
• W4293516718 cites W3039055826 @default.
• W4293516718 cites W3092767555 @default.
• W4293516718 cites W3137573777 @default.
• W4293516718 cites W3137625569 @default.
• W4293516718 cites W3162888561 @default.
• W4293516718 cites W3164336527 @default.
• W4293516718 cites W3164445007 @default.
• W4293516718 cites W4200090035 @default.
• W4293516718 cites W4206436744 @default.
• W4293516718 cites W4210990602 @default.
• W4293516718 cites W4224257171 @default.
• W4293516718 cites W4226175083 @default.
• W4293516718 doi "https://doi.org/10.3390/cancers14163844" @default.
• W4293516718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36010838" @default.
• W4293516718 hasPublicationYear "2022" @default.
• W4293516718 type Work @default.
• W4293516718 citedByCount "1" @default.
• W4293516718 countsByYear W42935167182022 @default.
• W4293516718 crossrefType "journal-article" @default.
• W4293516718 hasAuthorship W4293516718A5004153994 @default.
• W4293516718 hasAuthorship W4293516718A5016219286 @default.
• W4293516718 hasAuthorship W4293516718A5017976754 @default.
• W4293516718 hasAuthorship W4293516718A5018456614 @default.
• W4293516718 hasAuthorship W4293516718A5035948170 @default.
• W4293516718 hasAuthorship W4293516718A5065498178 @default.
• W4293516718 hasAuthorship W4293516718A5073592253 @default.
• W4293516718 hasAuthorship W4293516718A5084554327 @default.
• W4293516718 hasBestOaLocation W42935167181 @default.
• W4293516718 hasConcept C121608353 @default.
• W4293516718 hasConcept C126322002 @default.
• W4293516718 hasConcept C143998085 @default.
• W4293516718 hasConcept C2777701055 @default.
• W4293516718 hasConcept C2778424827 @default.
• W4293516718 hasConcept C526805850 @default.
• W4293516718 hasConcept C71924100 @default.
• W4293516718 hasConcept C90924648 @default.
• W4293516718 hasConcept C99476002 @default.
• W4293516718 hasConceptScore W4293516718C121608353 @default.
• W4293516718 hasConceptScore W4293516718C126322002 @default.
• W4293516718 hasConceptScore W4293516718C143998085 @default.
• W4293516718 hasConceptScore W4293516718C2777701055 @default.
• W4293516718 hasConceptScore W4293516718C2778424827 @default.
• W4293516718 hasConceptScore W4293516718C526805850 @default.
• W4293516718 hasConceptScore W4293516718C71924100 @default.
• W4293516718 hasConceptScore W4293516718C90924648 @default.
• W4293516718 hasConceptScore W4293516718C99476002 @default.
• W4293516718 hasFunder F4320323482 @default.
• W4293516718 hasIssue "16" @default.
• W4293516718 hasLocation W42935167181 @default.
• W4293516718 hasLocation W42935167182 @default.
• W4293516718 hasLocation W42935167183 @default.
• W4293516718 hasLocation W42935167184 @default.
• W4293516718 hasOpenAccess W4293516718 @default.
• W4293516718 hasPrimaryLocation W42935167181 @default.
• W4293516718 hasRelatedWork W2030612376 @default.
• W4293516718 hasRelatedWork W2168952713 @default.
• W4293516718 hasRelatedWork W2392730113 @default.
• W4293516718 hasRelatedWork W2409949902 @default.
• W4293516718 hasRelatedWork W2410096339 @default.
• W4293516718 hasRelatedWork W3004259476 @default.
• W4293516718 hasRelatedWork W3021503417 @default.
• W4293516718 hasRelatedWork W3039284339 @default.
• W4293516718 hasRelatedWork W3090963952 @default.
• W4293516718 hasRelatedWork W2752295243 @default.

• next