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- W4293516721 abstract "The emergence of chimeric antigen receptor (CAR) T cell therapy has shifted the paradigm of malignant tumor treatment, especially the advent of CD19-directed CAR-T cell therapy for the treatment of relapsed/refractory (R/R) B-cell malignancies. Although CAR-T cell therapy has promising effects, some patients are resistant to this treatment, leaving them with limited options. Therefore, strategies to overcome resistance to CAR-T cell therapy are needed. We retrospectively studied three R/R diffuse large B-cell lymphoma patients who were resistant to CAR-T cell therapy and whose disease was controlled after receiving pembrolizumab, 21D4 CAR-T cells, or ibrutinib and venetoclax. Some promising prevention and treatment strategies to overcome treatment resistance are also discussed." @default.
- W4293516721 created "2022-08-30" @default.
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- W4293516721 date "2022-08-10" @default.
- W4293516721 modified "2023-10-18" @default.
- W4293516721 title "Strategies to overcome CAR-T cell resistance in clinical work: A single-institute experience" @default.
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- W4293516721 doi "https://doi.org/10.3389/fimmu.2022.929221" @default.
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