FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293530270> ?p ?o ?g. }

• W4293530270 abstract "Chemodynamic therapy (CDT) is a kind of anti-tumor strategy emerging in recent years, but the concentration of hydrogen peroxide (H2O2) in the tumor microenvironment is insufficient, and it is difficult for a single CDT to completely inhibit tumor growth. Here, we designed a CuS nanoparticles (NPs) and camptothecin (CPT) co-loaded thermosensitive injectable hydrogel (SCH) with self-supplied H2O2 for enhanced CDT. SCH is composed of CuS NPs and CPT loaded into agarose hydrogel according to a certain ratio. We injected SCH into the tumor tissue of mice, and under the irradiation of near-infrared region (NIR) laser at 808 nm, CuS NPs converted the NIR laser into heat to realize photothermal therapy (PTT), and at the same time, the agarose hydrogel was changed into a sol state and CPT was released. CPT activates nicotinamide adenine dinucleotide phosphate oxidase, increases the level of H2O2 inside the tumor, and realizes the self-supply of H2O2. At the same time, CuS can accelerate the release of Cu2+ in an acidic environment and light, combined with H2O2 generated by CPT for CDT treatment, and consume glutathione in tumor and generate hydroxyl radical, thus inducing tumor cell apoptosis. The SCH system we constructed achieved an extremely high tumor inhibition rate in vitro and in vivo, presenting a new idea for designing future chemical kinetic systems." @default.
• W4293530270 created "2022-08-30" @default.
• W4293530270 creator A5009232538 @default.
• W4293530270 creator A5040776228 @default.
• W4293530270 creator A5047465250 @default.
• W4293530270 creator A5048114289 @default.
• W4293530270 creator A5053550273 @default.
• W4293530270 creator A5062092464 @default.
• W4293530270 date "2022-08-29" @default.
• W4293530270 modified "2023-09-26" @default.
• W4293530270 title "CuS nanoparticles and camptothecin co-loaded thermosensitive injectable hydrogel with self-supplied H2O2 for enhanced chemodynamic therapy" @default.
• W4293530270 cites W1994220134 @default.
• W4293530270 cites W2004283265 @default.
• W4293530270 cites W2041460833 @default.
• W4293530270 cites W2168944768 @default.
• W4293530270 cites W2581441755 @default.
• W4293530270 cites W2750348097 @default.
• W4293530270 cites W2767844932 @default.
• W4293530270 cites W2800971234 @default.
• W4293530270 cites W2899707370 @default.
• W4293530270 cites W2907509206 @default.
• W4293530270 cites W2945876533 @default.
• W4293530270 cites W2987244339 @default.
• W4293530270 cites W3008370485 @default.
• W4293530270 cites W3014767071 @default.
• W4293530270 cites W3043537223 @default.
• W4293530270 cites W3081387755 @default.
• W4293530270 cites W3094063492 @default.
• W4293530270 cites W3099105897 @default.
• W4293530270 cites W3127352399 @default.
• W4293530270 cites W3129647658 @default.
• W4293530270 cites W3132796040 @default.
• W4293530270 cites W3136274281 @default.
• W4293530270 cites W3139166183 @default.
• W4293530270 cites W3143970081 @default.
• W4293530270 cites W3144296667 @default.
• W4293530270 cites W3155990766 @default.
• W4293530270 cites W3158263762 @default.
• W4293530270 cites W3169912805 @default.
• W4293530270 cites W3171968492 @default.
• W4293530270 cites W3176618862 @default.
• W4293530270 cites W3181251993 @default.
• W4293530270 cites W3184063455 @default.
• W4293530270 cites W3191019623 @default.
• W4293530270 cites W3214714591 @default.
• W4293530270 cites W3217118718 @default.
• W4293530270 cites W4200158200 @default.
• W4293530270 cites W4205259704 @default.
• W4293530270 cites W4213450297 @default.
• W4293530270 cites W4214838848 @default.
• W4293530270 cites W4220846326 @default.
• W4293530270 cites W4225147111 @default.
• W4293530270 cites W4229035951 @default.
• W4293530270 cites W4280580780 @default.
• W4293530270 cites W4281489131 @default.
• W4293530270 doi "https://doi.org/10.3389/fbioe.2022.1003777" @default.
• W4293530270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36105600" @default.
• W4293530270 hasPublicationYear "2022" @default.
• W4293530270 type Work @default.
• W4293530270 citedByCount "1" @default.
• W4293530270 countsByYear W42935302702023 @default.
• W4293530270 crossrefType "journal-article" @default.
• W4293530270 hasAuthorship W4293530270A5009232538 @default.
• W4293530270 hasAuthorship W4293530270A5040776228 @default.
• W4293530270 hasAuthorship W4293530270A5047465250 @default.
• W4293530270 hasAuthorship W4293530270A5048114289 @default.
• W4293530270 hasAuthorship W4293530270A5053550273 @default.
• W4293530270 hasAuthorship W4293530270A5062092464 @default.
• W4293530270 hasBestOaLocation W42935302701 @default.
• W4293530270 hasConcept C12554922 @default.
• W4293530270 hasConcept C139066938 @default.
• W4293530270 hasConcept C150903083 @default.
• W4293530270 hasConcept C155672457 @default.
• W4293530270 hasConcept C15920480 @default.
• W4293530270 hasConcept C171250308 @default.
• W4293530270 hasConcept C178790620 @default.
• W4293530270 hasConcept C181199279 @default.
• W4293530270 hasConcept C182606246 @default.
• W4293530270 hasConcept C185592680 @default.
• W4293530270 hasConcept C188109995 @default.
• W4293530270 hasConcept C192562407 @default.
• W4293530270 hasConcept C207001950 @default.
• W4293530270 hasConcept C2776107976 @default.
• W4293530270 hasConcept C2776778087 @default.
• W4293530270 hasConcept C2777989768 @default.
• W4293530270 hasConcept C2778476535 @default.
• W4293530270 hasConcept C2779682216 @default.
• W4293530270 hasConcept C3020616263 @default.
• W4293530270 hasConcept C38485361 @default.
• W4293530270 hasConcept C48349386 @default.
• W4293530270 hasConcept C502942594 @default.
• W4293530270 hasConcept C521977710 @default.
• W4293530270 hasConcept C533411734 @default.
• W4293530270 hasConcept C55493867 @default.
• W4293530270 hasConcept C86803240 @default.
• W4293530270 hasConceptScore W4293530270C12554922 @default.
• W4293530270 hasConceptScore W4293530270C139066938 @default.
• W4293530270 hasConceptScore W4293530270C150903083 @default.
• W4293530270 hasConceptScore W4293530270C155672457 @default.
• W4293530270 hasConceptScore W4293530270C15920480 @default.

• next