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• W4293532924 abstract "Background: High blood pressure (BP), particularly systolic BP (SBP), is the major modifiable risk factor for cardiovascular diseases and related disorders of aging. SBP increases markedly with aging in women such that the prevalence of above-normal SBP (i.e., ≥120 mmHg) in postmenopausal women exceeds rates in age-matched men. This increase in SBP is associated with vascular endothelial dysfunction, mediated by excessive reactive oxygen species-induced oxidative stress and consequent reductions in nitric oxide bioavailability. Moderate-intensity aerobic exercise is a recommended lifestyle strategy for reducing SBP. However, adherence to aerobic exercise guidelines among postmenopausal women is low (<30%) and aerobic exercise does not consistently enhance endothelial function in estrogen-deficient postmenopausal women. High-resistance inspiratory muscle strength training (IMST) is a time-efficient, adherable lifestyle intervention that involves inhaling against resistance through a handheld device (30 breaths/day). Here, we present the protocol for a randomized controlled trial investigating the efficacy of 3 months of high-resistance IMST compared to guideline-based, standard-of-care aerobic exercise training for decreasing SBP and improving endothelial function in estrogen-deficient postmenopausal women with above-normal SBP (120-159 mmHg) at baseline (ClinicalTrials.gov Identifier: NCT05000515). Methods: A randomized, single-blind, parallel-group design clinical trial will be conducted in 72 (36/group) estrogen-deficient postmenopausal women with above-normal SBP. Participants will complete baseline testing and then be randomized to either 3 months of high-resistance IMST (30 breaths/day, 6 days/week, 75% maximal inspiratory pressure) or moderate-intensity aerobic exercise training (brisk walking 25 min/day, 6 days/week, 40-60% heart rate reserve). Outcome measures will be assessed after 3 months of either intervention. Following end-intervention testing, participants will abstain from their assigned intervention for 6 weeks, after which BP and endothelial function will be assessed to evaluate the potential persistent effects of the intervention on the primary and secondary outcomes. Discussion: This study is designed to compare the effectiveness of time-efficient, high-resistance IMST to guideline-based aerobic exercise training for lowering SBP and improving endothelial function, and interrogating potential mechanisms of action, in estrogen-deficient postmenopausal women. Clinical Trial Registration: ClinicalTrials.gov, Identifier: NCT05000515." @default.
• W4293532924 created "2022-08-30" @default.
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• W4293532924 date "2022-08-29" @default.
• W4293532924 modified "2023-10-18" @default.
• W4293532924 title "Inspiratory muscle strength training for lowering blood pressure and improving endothelial function in postmenopausal women: comparison with “standard of care” aerobic exercise" @default.
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• W4293532924 cites W1977268756 @default.
• W4293532924 cites W1983986440 @default.
• W4293532924 cites W1987730138 @default.
• W4293532924 cites W1989804733 @default.
• W4293532924 cites W1990521966 @default.
• W4293532924 cites W1992856469 @default.
• W4293532924 cites W1995032801 @default.
• W4293532924 cites W2004395090 @default.
• W4293532924 cites W2008791277 @default.
• W4293532924 cites W2015177574 @default.
• W4293532924 cites W2022300573 @default.
• W4293532924 cites W2034897558 @default.
• W4293532924 cites W2039014945 @default.
• W4293532924 cites W2039052750 @default.
• W4293532924 cites W2046186201 @default.
• W4293532924 cites W2050504601 @default.
• W4293532924 cites W2050663836 @default.
• W4293532924 cites W2054874512 @default.
• W4293532924 cites W2058149090 @default.
• W4293532924 cites W2059819631 @default.
• W4293532924 cites W2065475382 @default.
• W4293532924 cites W2065566393 @default.
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• W4293532924 cites W2080269802 @default.
• W4293532924 cites W2085073101 @default.
• W4293532924 cites W2085355921 @default.
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• W4293532924 cites W2109554053 @default.
• W4293532924 cites W2117026208 @default.
• W4293532924 cites W2122330962 @default.
• W4293532924 cites W2122522567 @default.
• W4293532924 cites W2127500695 @default.
• W4293532924 cites W2136018951 @default.
• W4293532924 cites W2136329682 @default.
• W4293532924 cites W2143260060 @default.
• W4293532924 cites W2145200932 @default.
• W4293532924 cites W2152944003 @default.
• W4293532924 cites W2153553951 @default.
• W4293532924 cites W2154375091 @default.
• W4293532924 cites W2157326702 @default.
• W4293532924 cites W2173257315 @default.
• W4293532924 cites W2271142508 @default.
• W4293532924 cites W2285222531 @default.
• W4293532924 cites W2323341107 @default.
• W4293532924 cites W2400551271 @default.
• W4293532924 cites W2551078167 @default.
• W4293532924 cites W2622139725 @default.
• W4293532924 cites W2769061712 @default.
• W4293532924 cites W2770837559 @default.
• W4293532924 cites W2779629725 @default.
• W4293532924 cites W2861366762 @default.
• W4293532924 cites W2900726805 @default.
• W4293532924 cites W2943953309 @default.
• W4293532924 cites W2945731581 @default.
• W4293532924 cites W2945961700 @default.
• W4293532924 cites W2976334238 @default.
• W4293532924 cites W2999981125 @default.
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• W4293532924 cites W3080843307 @default.
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• W4293532924 cites W328095766 @default.
• W4293532924 cites W4210242902 @default.
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• W4293532924 doi "https://doi.org/10.3389/fphys.2022.967478" @default.
• W4293532924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36105300" @default.
• W4293532924 hasPublicationYear "2022" @default.
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