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- W4293545209 abstract "The minichromosome maintenance (MCM) 8/9 helicase is a AAA+ complex involved in DNA replication-associated repair. Despite high sequence homology to the MCM2-7 helicase, a precise cellular role for MCM8/9 has remained elusive. We have interrogated the DNA synthesis ability and replication fork stability in cells lacking MCM8 or 9 and find that there is a functional partitioning of MCM8/9 activity between promoting replication fork progression and protecting persistently stalled forks. The helicase function of MCM8/9 aids in normal replication fork progression, but upon persistent stalling, MCM8/9 directs additional downstream stabilizers, including BRCA1 and Rad51, to protect forks from excessive degradation. Loss of MCM8 or 9 slows the overall replication rate and allows for excessive nascent strand degradation, detectable by increased markers of genomic damage. This evidence defines multifunctional roles for MCM8/9 in promoting normal replication fork progression and genome integrity following stress." @default.
- W4293545209 created "2022-08-30" @default.
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- W4293545209 date "2022-08-30" @default.
- W4293545209 modified "2023-09-26" @default.
- W4293545209 title "A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress" @default.
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- W4293545209 doi "https://doi.org/10.1038/s41467-022-32583-8" @default.
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