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- W4293558178 endingPage "101140" @default.
- W4293558178 startingPage "101140" @default.
- W4293558178 abstract "Autoimmune diseases affect tens of millions of people just in the United States alone. Most of the available treatment options are aimed at reducing symptoms but do not lead to cures. Individuals affected with autoimmune diseases suffer from the imbalance between tolerogenic and immunogenic functions of their immune system. Often pathogenesis is mediated by autoreactive B and T cells that escape central tolerance and react against self-antigens attacking healthy tissues in the body. In recent years Siglecs, sialic-acid-binding immunoglobulin (Ig)-like lectins, have gained attention as immune checkpoints for therapeutic interventions to dampen excessive immune responses and to restore immune tolerance in autoimmune diseases. Many Siglecs function as inhibitory receptors suppressing activation signals in various immune cells through binding to sialic acid ligands as signatures of self. In this review, we highlight potential of Siglecs in suppressing immune responses causing autoimmune diseases. In particular, we cover the roles of CD22 and Siglec-G/Siglec-10 in regulating autoreactive B cell responses. We discuss several functions of Siglec-10 in the immune modulation of other immune cells, and the potential of therapeutic strategies for restoring immune tolerance by targeting Siglecs and expanding regulatory T cells. Finally, we briefly review efforts evaluating Siglec-based biomarkers to monitor autoimmune diseases." @default.
- W4293558178 created "2022-08-30" @default.
- W4293558178 creator A5039824850 @default.
- W4293558178 creator A5055234279 @default.
- W4293558178 date "2023-04-01" @default.
- W4293558178 modified "2023-10-15" @default.
- W4293558178 title "Impact of Siglecs on autoimmune diseases" @default.
- W4293558178 cites W14048388 @default.
- W4293558178 cites W1521669126 @default.
- W4293558178 cites W1540298277 @default.
- W4293558178 cites W1575585006 @default.
- W4293558178 cites W160562812 @default.
- W4293558178 cites W1715124350 @default.
- W4293558178 cites W1807438491 @default.
- W4293558178 cites W1900528944 @default.
- W4293558178 cites W1909688331 @default.
- W4293558178 cites W1967297513 @default.
- W4293558178 cites W1969295534 @default.
- W4293558178 cites W1969374521 @default.
- W4293558178 cites W1971907885 @default.
- W4293558178 cites W1974313653 @default.
- W4293558178 cites W1978470483 @default.
- W4293558178 cites W1984198105 @default.
- W4293558178 cites W1988267027 @default.
- W4293558178 cites W1992360391 @default.
- W4293558178 cites W1992619826 @default.
- W4293558178 cites W1992789686 @default.
- W4293558178 cites W1996486759 @default.
- W4293558178 cites W2002726823 @default.
- W4293558178 cites W2006194219 @default.
- W4293558178 cites W2007307182 @default.
- W4293558178 cites W2010218451 @default.
- W4293558178 cites W2010775550 @default.
- W4293558178 cites W2015817628 @default.
- W4293558178 cites W2023216402 @default.
- W4293558178 cites W2029602090 @default.
- W4293558178 cites W2030703627 @default.
- W4293558178 cites W2031302570 @default.
- W4293558178 cites W2033388004 @default.
- W4293558178 cites W2033799256 @default.
- W4293558178 cites W2034356272 @default.
- W4293558178 cites W2034949980 @default.
- W4293558178 cites W2038689503 @default.
- W4293558178 cites W2045621416 @default.
- W4293558178 cites W2050481876 @default.
- W4293558178 cites W2051927648 @default.
- W4293558178 cites W2052666754 @default.
- W4293558178 cites W2052756021 @default.
- W4293558178 cites W2053257624 @default.
- W4293558178 cites W2054083031 @default.
- W4293558178 cites W2054409932 @default.
- W4293558178 cites W2056024588 @default.
- W4293558178 cites W2062923968 @default.
- W4293558178 cites W2065405440 @default.
- W4293558178 cites W2065750747 @default.
- W4293558178 cites W2066601085 @default.
- W4293558178 cites W2070666617 @default.
- W4293558178 cites W2072845025 @default.
- W4293558178 cites W2074292775 @default.
- W4293558178 cites W2075853683 @default.
- W4293558178 cites W2076032448 @default.
- W4293558178 cites W2076198413 @default.
- W4293558178 cites W2079439641 @default.
- W4293558178 cites W2079657156 @default.
- W4293558178 cites W2084416533 @default.
- W4293558178 cites W2087143668 @default.
- W4293558178 cites W2088332148 @default.
- W4293558178 cites W2092747941 @default.
- W4293558178 cites W2096874324 @default.
- W4293558178 cites W2097811455 @default.
- W4293558178 cites W2098829858 @default.
- W4293558178 cites W2102321925 @default.
- W4293558178 cites W2106096425 @default.
- W4293558178 cites W2110375406 @default.
- W4293558178 cites W2112785873 @default.
- W4293558178 cites W2114527814 @default.
- W4293558178 cites W2116048793 @default.
- W4293558178 cites W2124079316 @default.
- W4293558178 cites W2126522707 @default.
- W4293558178 cites W2135556297 @default.
- W4293558178 cites W2136389594 @default.
- W4293558178 cites W2137350523 @default.
- W4293558178 cites W2148226248 @default.
- W4293558178 cites W2149029145 @default.
- W4293558178 cites W2149048073 @default.
- W4293558178 cites W2153142861 @default.
- W4293558178 cites W2153389047 @default.
- W4293558178 cites W2156772263 @default.
- W4293558178 cites W2157779792 @default.
- W4293558178 cites W2158924104 @default.
- W4293558178 cites W2165528840 @default.
- W4293558178 cites W2167940772 @default.
- W4293558178 cites W2169924343 @default.
- W4293558178 cites W2202439768 @default.
- W4293558178 cites W2219152942 @default.
- W4293558178 cites W2290698646 @default.
- W4293558178 cites W2297227119 @default.
- W4293558178 cites W2324016220 @default.