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- W4293559825 endingPage "103736" @default.
- W4293559825 startingPage "103736" @default.
- W4293559825 abstract "Nose-to-Brain drug delivery can bypass blood-brain-barrier though the olfactory region using different devices and dosage forms. This work aimed to fabricate and characterize a novel dosage form, nasal inserts, containing rivastigmine tartrate. Four formulae were fabricated using gelatin/HPMC matrix in a different ratios and grades. The fabricated nasal inserts were characterized in terms of physical appearance, surface pH, diameter and length, mechanical properties, and mucoadhesive behaviour. The content uniformity, release profile, Ex-vivo permeation of rivastigmine tartrate were also investigated. The release profiles for all nasal inserts were fitted to kinetics model. Physical and chemical stability of the dosage form were evaluated. F2 appears to have the best sustained release profile, where F1 appears to have the best immediate release profile." @default.
- W4293559825 created "2022-08-30" @default.
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- W4293559825 date "2022-10-01" @default.
- W4293559825 modified "2023-09-26" @default.
- W4293559825 title "Formulation and evaluation of nasal insert for nose-to-brain drug delivery of rivastigmine tartrate" @default.
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- W4293559825 doi "https://doi.org/10.1016/j.jddst.2022.103736" @default.
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