Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293565745> ?p ?o ?g. }
- W4293565745 endingPage "2554" @default.
- W4293565745 startingPage "2538" @default.
- W4293565745 abstract "The Toll‐like receptor (TLR)7‐ and TLR9‐dependent signalling cascade is responsible for production of a large amount of alpha interferon by plasmacytoid dendritic cells upon viral infection. Here, we show that Middle East respiratory syndrome coronavirus (MERS‐CoV) accessory protein ORF4b has the most potential among the MERS‐CoV accessory proteins to inhibit the TLR7/9‐signaling‐dependent alpha interferon production. ORF4b protein, which has a bipartite nuclear localization signal, was found to bind to IKKα, a kinase responsible for phosphorylation of interferon regulatory factor (IRF)7. This interaction caused relocation of a large proportion of IKKα from the cytoplasm to the nucleus. Studies using ORF4b and IKKα mutants demonstrated that ORF4b protein inhibited IKKα‐mediated IRF7 phosphorylation by sequestering IKKα in the nucleus and by impeding the phosphorylation process of cytoplasmic IKKα." @default.
- W4293565745 created "2022-08-30" @default.
- W4293565745 creator A5001079462 @default.
- W4293565745 creator A5029676343 @default.
- W4293565745 creator A5036674786 @default.
- W4293565745 creator A5077618412 @default.
- W4293565745 date "2022-09-08" @default.
- W4293565745 modified "2023-10-15" @default.
- W4293565745 title "Middle East respiratory syndrome coronavirus <scp>ORF4b</scp> protein inhibits <scp>TLR7</scp>‐ and <scp>TLR9</scp>‐dependent alpha interferon induction" @default.
- W4293565745 cites W1738782024 @default.
- W4293565745 cites W1969430178 @default.
- W4293565745 cites W1970468763 @default.
- W4293565745 cites W1976637392 @default.
- W4293565745 cites W1994147401 @default.
- W4293565745 cites W1996909392 @default.
- W4293565745 cites W2006555229 @default.
- W4293565745 cites W2009392385 @default.
- W4293565745 cites W2017380851 @default.
- W4293565745 cites W2029975301 @default.
- W4293565745 cites W2035299766 @default.
- W4293565745 cites W2036477696 @default.
- W4293565745 cites W2037454778 @default.
- W4293565745 cites W2046461758 @default.
- W4293565745 cites W2048162805 @default.
- W4293565745 cites W2053503974 @default.
- W4293565745 cites W2067678108 @default.
- W4293565745 cites W2077575210 @default.
- W4293565745 cites W2092230550 @default.
- W4293565745 cites W2104151172 @default.
- W4293565745 cites W2108046273 @default.
- W4293565745 cites W2111922856 @default.
- W4293565745 cites W2121960517 @default.
- W4293565745 cites W2133889672 @default.
- W4293565745 cites W2134847649 @default.
- W4293565745 cites W2137624902 @default.
- W4293565745 cites W2153846132 @default.
- W4293565745 cites W2289810872 @default.
- W4293565745 cites W2323018461 @default.
- W4293565745 cites W2399160889 @default.
- W4293565745 cites W2546157736 @default.
- W4293565745 cites W2747597014 @default.
- W4293565745 cites W2784713136 @default.
- W4293565745 cites W2806404741 @default.
- W4293565745 cites W2886432125 @default.
- W4293565745 cites W2895851852 @default.
- W4293565745 cites W2970172816 @default.
- W4293565745 cites W2985545315 @default.
- W4293565745 cites W3047477951 @default.
- W4293565745 cites W3176967764 @default.
- W4293565745 cites W3208635238 @default.
- W4293565745 cites W4225939175 @default.
- W4293565745 doi "https://doi.org/10.1002/1873-3468.14486" @default.
- W4293565745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36053897" @default.
- W4293565745 hasPublicationYear "2022" @default.
- W4293565745 type Work @default.
- W4293565745 citedByCount "1" @default.
- W4293565745 countsByYear W42935657452023 @default.
- W4293565745 crossrefType "journal-article" @default.
- W4293565745 hasAuthorship W4293565745A5001079462 @default.
- W4293565745 hasAuthorship W4293565745A5029676343 @default.
- W4293565745 hasAuthorship W4293565745A5036674786 @default.
- W4293565745 hasAuthorship W4293565745A5077618412 @default.
- W4293565745 hasConcept C100175707 @default.
- W4293565745 hasConcept C104317684 @default.
- W4293565745 hasConcept C11960822 @default.
- W4293565745 hasConcept C136449434 @default.
- W4293565745 hasConcept C150194340 @default.
- W4293565745 hasConcept C153911025 @default.
- W4293565745 hasConcept C159047783 @default.
- W4293565745 hasConcept C170493617 @default.
- W4293565745 hasConcept C185592680 @default.
- W4293565745 hasConcept C190727270 @default.
- W4293565745 hasConcept C2776178377 @default.
- W4293565745 hasConcept C2776709828 @default.
- W4293565745 hasConcept C2776966659 @default.
- W4293565745 hasConcept C2777730290 @default.
- W4293565745 hasConcept C2779138994 @default.
- W4293565745 hasConcept C2779836521 @default.
- W4293565745 hasConcept C2780209191 @default.
- W4293565745 hasConcept C2909179924 @default.
- W4293565745 hasConcept C55493867 @default.
- W4293565745 hasConcept C62478195 @default.
- W4293565745 hasConcept C86803240 @default.
- W4293565745 hasConcept C9173399 @default.
- W4293565745 hasConcept C95444343 @default.
- W4293565745 hasConceptScore W4293565745C100175707 @default.
- W4293565745 hasConceptScore W4293565745C104317684 @default.
- W4293565745 hasConceptScore W4293565745C11960822 @default.
- W4293565745 hasConceptScore W4293565745C136449434 @default.
- W4293565745 hasConceptScore W4293565745C150194340 @default.
- W4293565745 hasConceptScore W4293565745C153911025 @default.
- W4293565745 hasConceptScore W4293565745C159047783 @default.
- W4293565745 hasConceptScore W4293565745C170493617 @default.
- W4293565745 hasConceptScore W4293565745C185592680 @default.
- W4293565745 hasConceptScore W4293565745C190727270 @default.
- W4293565745 hasConceptScore W4293565745C2776178377 @default.
- W4293565745 hasConceptScore W4293565745C2776709828 @default.
- W4293565745 hasConceptScore W4293565745C2776966659 @default.