FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293567701> ?p ?o ?g. }

• W4293567701 abstract "Abstract Background Cardiac fibrosis is a leading cause of cardiac dysfunction in patients with diabetes. However, the underlying mechanisms of cardiac fibrosis remain unclear. This study aimed to investigate the role of the long non-coding RNA (LncRNA) Airn in the pathogenesis of cardiac fibrosis in diabetic cardiomyopathy (DCM) and its underlying mechanism. Methods Diabetes mellitus (DM) was induced in mice by streptozotocin injection. An intramyocardial adeno-associated virus (AAV) was used to manipulate Airn expression. The functional significance and underlying mechanisms in DCM fibrosis were investigated both in vitro and in vivo. Results Diabetic hearts showed a significant impairment in cardiac function, accompanied by obviously increased cardiac fibrosis. Interestingly, lncRNA Airn expression was significantly decreased in both diabetic hearts and high glucose (HG)-treated cardiac fibroblasts (CFs). AAV-mediated Airn reconstitution prevented cardiac fibrosis and the development of DCM, while Airn knockdown induced cardiac fibrosis phenotyping DCM. As in vitro , Airn reversed HG-induced fibroblast-myofibroblast transition, aberrant CFs proliferation and section of collagen I. In contrast, Airn knockdown mimicked a HG-induced CFs phenotype. Mechanistically, we identified that Airn exerts anti-fibrotic effects by directly binding to insulin-like growth factor 2 mRNA-binding protein 2 (IMP2) and further prevents its ubiquitination-dependent degradation. Moreover, we revealed that Airn /IMP2 protected p53 mRNA from degradation in m6A manner, leading to CF cell cycle arrest and reduced cardiac fibrosis. As a result, ablation of p53 blunted the inhibitory effects of Airn on fibroblast activation and cardiac fibrosis. Conclusions Our study demonstrated for the first time that Airn prevented the development of cardiac fibrosis in diabetic heart via IMP2-p53 axis in an m6A dependent manner. LncRNA Airn could be a promising therapeutic target for cardiac fibrosis in DCM." @default.
• W4293567701 created "2022-08-30" @default.
• W4293567701 creator A5009143841 @default.
• W4293567701 creator A5014248614 @default.
• W4293567701 creator A5024565560 @default.
• W4293567701 creator A5051949776 @default.
• W4293567701 creator A5052274720 @default.
• W4293567701 creator A5052304130 @default.
• W4293567701 creator A5052628613 @default.
• W4293567701 creator A5057113749 @default.
• W4293567701 creator A5063286396 @default.
• W4293567701 creator A5074352962 @default.
• W4293567701 creator A5076036088 @default.
• W4293567701 creator A5090780734 @default.
• W4293567701 creator A5091369400 @default.
• W4293567701 date "2022-08-30" @default.
• W4293567701 modified "2023-09-27" @default.
• W4293567701 title "LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis" @default.
• W4293567701 cites W1942211366 @default.
• W4293567701 cites W1954140294 @default.
• W4293567701 cites W1988050826 @default.
• W4293567701 cites W2009308529 @default.
• W4293567701 cites W2019615270 @default.
• W4293567701 cites W2048755332 @default.
• W4293567701 cites W2064140451 @default.
• W4293567701 cites W2078964320 @default.
• W4293567701 cites W2091169722 @default.
• W4293567701 cites W2101732802 @default.
• W4293567701 cites W2113693506 @default.
• W4293567701 cites W2124015466 @default.
• W4293567701 cites W2137694167 @default.
• W4293567701 cites W2152894234 @default.
• W4293567701 cites W2163579397 @default.
• W4293567701 cites W2164773184 @default.
• W4293567701 cites W2176811057 @default.
• W4293567701 cites W2230697532 @default.
• W4293567701 cites W2549388125 @default.
• W4293567701 cites W2564167725 @default.
• W4293567701 cites W2588001042 @default.
• W4293567701 cites W2614668726 @default.
• W4293567701 cites W2616084347 @default.
• W4293567701 cites W2641818139 @default.
• W4293567701 cites W2657666189 @default.
• W4293567701 cites W2661816031 @default.
• W4293567701 cites W2739713863 @default.
• W4293567701 cites W2742824716 @default.
• W4293567701 cites W2754499625 @default.
• W4293567701 cites W2781723573 @default.
• W4293567701 cites W2782072995 @default.
• W4293567701 cites W2793652484 @default.
• W4293567701 cites W2793785833 @default.
• W4293567701 cites W2837459302 @default.
• W4293567701 cites W2866016060 @default.
• W4293567701 cites W2890037152 @default.
• W4293567701 cites W2891777345 @default.
• W4293567701 cites W2901585229 @default.
• W4293567701 cites W2914903642 @default.
• W4293567701 cites W2921664390 @default.
• W4293567701 cites W2923286987 @default.
• W4293567701 cites W2946217053 @default.
• W4293567701 cites W2948257100 @default.
• W4293567701 cites W2950438903 @default.
• W4293567701 cites W2951746943 @default.
• W4293567701 cites W2953485758 @default.
• W4293567701 cites W2972869264 @default.
• W4293567701 cites W2989929298 @default.
• W4293567701 cites W2992968352 @default.
• W4293567701 cites W3000177331 @default.
• W4293567701 cites W3001081515 @default.
• W4293567701 cites W3006998660 @default.
• W4293567701 cites W3007690872 @default.
• W4293567701 cites W3016459825 @default.
• W4293567701 cites W3026833600 @default.
• W4293567701 cites W3089789954 @default.
• W4293567701 cites W3090500516 @default.
• W4293567701 cites W3110629027 @default.
• W4293567701 cites W3128850006 @default.
• W4293567701 cites W3135768598 @default.
• W4293567701 cites W3139249023 @default.
• W4293567701 cites W3167722710 @default.
• W4293567701 cites W3184073125 @default.
• W4293567701 cites W3190305392 @default.
• W4293567701 cites W4210288749 @default.
• W4293567701 doi "https://doi.org/10.21203/rs.3.rs-1724671/v2" @default.
• W4293567701 hasPublicationYear "2022" @default.
• W4293567701 type Work @default.
• W4293567701 citedByCount "0" @default.
• W4293567701 crossrefType "posted-content" @default.
• W4293567701 hasAuthorship W4293567701A5009143841 @default.
• W4293567701 hasAuthorship W4293567701A5014248614 @default.
• W4293567701 hasAuthorship W4293567701A5024565560 @default.
• W4293567701 hasAuthorship W4293567701A5051949776 @default.
• W4293567701 hasAuthorship W4293567701A5052274720 @default.
• W4293567701 hasAuthorship W4293567701A5052304130 @default.
• W4293567701 hasAuthorship W4293567701A5052628613 @default.
• W4293567701 hasAuthorship W4293567701A5057113749 @default.
• W4293567701 hasAuthorship W4293567701A5063286396 @default.
• W4293567701 hasAuthorship W4293567701A5074352962 @default.
• W4293567701 hasAuthorship W4293567701A5076036088 @default.
• W4293567701 hasAuthorship W4293567701A5090780734 @default.

• next