Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293572015> ?p ?o ?g. }
- W4293572015 endingPage "e059741" @default.
- W4293572015 startingPage "e059741" @default.
- W4293572015 abstract "Sedation and analgesia are recommended to be employed in the intensive care unit (ICU) to enhance patient comfort and safety, facilitate mechanical ventilation and reduce oxygen demands. However, the increasing evidence demonstrates that excessive sedation and analgesia might prolong mechanical ventilation and increase costs and mortality. Acupuncture is known to be able to attenuate pain, anxiety and agitation symptoms while avoiding excessive sedation and analgesia caused by drugs. Therefore, we present a protocol to investigate whether acupuncture, used for sedation and analgesia, can reduce the duration of mechanical ventilation, save medical resources and reduce the mortality of critically ill patients receiving mechanical ventilation.Prospective, randomised controlled trial is conducted on 180 adult medical/surgical ICU patients with mechanical ventilation needing sedation at 3 ICUs between 03 November 2021 and 16 August 2023. Patients will be treated with analgesia and sedation to achieve desired target sedation levels (Richmond Agitation Sedation Score of -2 to 1). Enrolled patients will be randomly assigned in a ratio of 1:1:1 to receive deep needle insertion with combined manual and alternating-mode electrical stimulation on acupoints (AC group), superficial needle insertion without manual stimulation and electrical stimulation on non-acupoints (SAC group), or no acupuncture intervention (NAC group). The primary outcome is the duration of mechanical ventilation from randomisation until patients are free of mechanical ventilation (including non-invasive) without reinstitution for the following 48 hours. Secondary endpoints include the dose of administered sedatives and analgesic at comparable sedation levels throughout the study, ICU length of stay, hospital length of stay. Additional outcomes include the prevalence and days of delirium in ICU, mortality in ICU and within 28 days after randomisation, and the number of ventilator free days in 28 days.This trial was approved by the ethics committee at Guangdong Provincial Hospital of Chinese Medicine. We will publish the study results.ChiCTR2100052650." @default.
- W4293572015 created "2022-08-30" @default.
- W4293572015 creator A5014390016 @default.
- W4293572015 creator A5019632632 @default.
- W4293572015 creator A5025268609 @default.
- W4293572015 creator A5069010948 @default.
- W4293572015 creator A5073429636 @default.
- W4293572015 creator A5088150060 @default.
- W4293572015 date "2022-08-01" @default.
- W4293572015 modified "2023-10-15" @default.
- W4293572015 title "Prospective comparison of acupuncture with sham acupuncture to determine impact on sedation and analgesia in mechanically ventilated critically ill patients (PASSION study): protocol for a randomised controlled trial" @default.
- W4293572015 cites W11610781 @default.
- W4293572015 cites W1520657679 @default.
- W4293572015 cites W1973968014 @default.
- W4293572015 cites W1976727358 @default.
- W4293572015 cites W1981844489 @default.
- W4293572015 cites W1982757796 @default.
- W4293572015 cites W1988825549 @default.
- W4293572015 cites W1992385150 @default.
- W4293572015 cites W1996623542 @default.
- W4293572015 cites W2004779711 @default.
- W4293572015 cites W2014787067 @default.
- W4293572015 cites W2017989233 @default.
- W4293572015 cites W2051028624 @default.
- W4293572015 cites W2054033832 @default.
- W4293572015 cites W2063332583 @default.
- W4293572015 cites W2073873235 @default.
- W4293572015 cites W2089197743 @default.
- W4293572015 cites W2099066338 @default.
- W4293572015 cites W2114262384 @default.
- W4293572015 cites W2116089402 @default.
- W4293572015 cites W2118789584 @default.
- W4293572015 cites W2123098876 @default.
- W4293572015 cites W2125413281 @default.
- W4293572015 cites W2130271602 @default.
- W4293572015 cites W2138021422 @default.
- W4293572015 cites W2147281871 @default.
- W4293572015 cites W2147703469 @default.
- W4293572015 cites W2156343006 @default.
- W4293572015 cites W2163395102 @default.
- W4293572015 cites W2164282722 @default.
- W4293572015 cites W2169330957 @default.
- W4293572015 cites W2172805132 @default.
- W4293572015 cites W2286321092 @default.
- W4293572015 cites W2296697021 @default.
- W4293572015 cites W2326168828 @default.
- W4293572015 cites W2359387207 @default.
- W4293572015 cites W2379751463 @default.
- W4293572015 cites W2569258603 @default.
- W4293572015 cites W2577187064 @default.
- W4293572015 cites W2612539986 @default.
- W4293572015 cites W2620684059 @default.
- W4293572015 cites W2754657935 @default.
- W4293572015 cites W2755471275 @default.
- W4293572015 cites W2800616231 @default.
- W4293572015 cites W2801379907 @default.
- W4293572015 cites W2804416226 @default.
- W4293572015 cites W2807420594 @default.
- W4293572015 cites W2883906474 @default.
- W4293572015 cites W2897948274 @default.
- W4293572015 cites W2901685169 @default.
- W4293572015 cites W2917268196 @default.
- W4293572015 cites W2951997665 @default.
- W4293572015 cites W2953536669 @default.
- W4293572015 cites W2965483652 @default.
- W4293572015 cites W2969839940 @default.
- W4293572015 cites W2972354916 @default.
- W4293572015 cites W2993843714 @default.
- W4293572015 cites W2996495425 @default.
- W4293572015 cites W2999725463 @default.
- W4293572015 cites W3006890871 @default.
- W4293572015 cites W3024968642 @default.
- W4293572015 cites W3047471877 @default.
- W4293572015 cites W3094109168 @default.
- W4293572015 cites W3181782271 @default.
- W4293572015 cites W3215242869 @default.
- W4293572015 cites W4206334752 @default.
- W4293572015 doi "https://doi.org/10.1136/bmjopen-2021-059741" @default.
- W4293572015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36041767" @default.
- W4293572015 hasPublicationYear "2022" @default.
- W4293572015 type Work @default.
- W4293572015 citedByCount "1" @default.
- W4293572015 countsByYear W42935720152023 @default.
- W4293572015 crossrefType "journal-article" @default.
- W4293572015 hasAuthorship W4293572015A5014390016 @default.
- W4293572015 hasAuthorship W4293572015A5019632632 @default.
- W4293572015 hasAuthorship W4293572015A5025268609 @default.
- W4293572015 hasAuthorship W4293572015A5069010948 @default.
- W4293572015 hasAuthorship W4293572015A5073429636 @default.
- W4293572015 hasAuthorship W4293572015A5088150060 @default.
- W4293572015 hasBestOaLocation W42935720151 @default.
- W4293572015 hasConcept C127413603 @default.
- W4293572015 hasConcept C141071460 @default.
- W4293572015 hasConcept C142724271 @default.
- W4293572015 hasConcept C168563851 @default.
- W4293572015 hasConcept C177713679 @default.
- W4293572015 hasConcept C200457457 @default.
- W4293572015 hasConcept C204787440 @default.