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• W4293574920 abstract "Background: Computer-aided diagnosis (CAD) systems have shown great potential as an effective auxiliary diagnostic tool in breast imaging. Previous studies have shown that S-Detect technology has a high accuracy in the differential diagnosis of breast masses. However, the application of S-Detect in clinical practice remains controversial, and the results vary among different clinical trials. This meta-analysis aimed to determine the diagnostic accuracy of S-Detect for distinguishing between benign and malignant breast masses. Methods: We searched PubMed, Cochrane Library, and CBM databases from inception to April 1, 2021. Meta-analysis was conducted using STATA version 14.0 and Meta-Disc version 1.4 softwares. We calculated the summary statistics for sensitivity (Sen), specificity (Spe), positive, and negative likelihood ratio (LR + /LR − ), diagnostic odds ratio(DOR), and summary receiver operating characteristic (SROC) curves. Cochran Q-statistic and I 2 test were used to evaluate the potential heterogeneity between studies. Sensitivity analysis was performed to evaluate the influence of single studies on the overall estimate. We also performed meta-regression analyses to investigate potential sources of heterogeneity. Results: Eleven studies that met all the inclusion criteria were included in the meta-analysis. A total of 951 malignant and 1866 benign breast masses were assessed. All breast masses were histologically confirmed using S-Detect. The pooled Sen was 0.82 (95% confidence interval(CI) = 0.74–0.88); the pooled Spe was 0.83 (95%CI = 0.78–0.88). The pooled LR + was 4.91 (95%CI = 3.75–6.41); the pooled negative LR − was 0.21 (95%CI = 0.15–0.31). The pooled DOR of S-Detect in the diagnosis of breast nodules was 23.12 (95% CI = 14.53–36.77). The area under the SROC curve was 0.90 (SE = 0.0166). No evidence of publication bias was found (t = 0.54, P = .61). Conclusions: Our meta-analysis indicates that S-Detect may have high diagnostic accuracy in distinguishing benign and malignant breast masses." @default.
• W4293574920 created "2022-08-30" @default.
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• W4293574920 date "2022-08-26" @default.
• W4293574920 modified "2023-10-14" @default.
• W4293574920 title "Diagnostic accuracy of S-Detect to breast cancer on ultrasonography: A meta-analysis (PRISMA)" @default.
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• W4293574920 doi "https://doi.org/10.1097/md.0000000000030359" @default.
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