Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293576869> ?p ?o ?g. }
- W4293576869 abstract "Subcutaneous tissue is a promising site for islet transplantation, but poor engraftment, due to hypoxia and low vascularity, hinders its prevalence. However, oxygen partial pressure (pO2) of the subcutaneous space (SC) and other sites were reported to be equivalent in several previous reports. This contradiction may be based on accidental puncture to the indwelling micro-vessels in target tissues. We therefore developed a novel optical sensor system, instead of a conventional Clark-type needle probe, for measuring tissue pO2 and found that pO2 of the SC was extremely low in comparison to other sites. To verify the utility of this method, we transplanted syngeneic rat islets subcutaneously into diabetic recipients under several oxygenation conditions using an oxygen delivery device, then performed pO2 measurement, glucose tolerance, and immunohistochemistry. The optical sensor system was validated by correlating the pO2 values with the transplanted islet function. Interestingly, this novel technique revealed that islet viability estimated by ATP/DNA assay reduced to less than 75% by hypoxic condition at the SC, indicating that islet engraftment may substantially improve if the pO2 levels reach those of the renal subcapsular space. Further refinements for a hypoxic condition using the present technique may contribute to improving the efficiency of subcutaneous islet transplantation." @default.
- W4293576869 created "2022-08-30" @default.
- W4293576869 creator A5002986571 @default.
- W4293576869 creator A5004774783 @default.
- W4293576869 creator A5011244445 @default.
- W4293576869 creator A5013785901 @default.
- W4293576869 creator A5020864858 @default.
- W4293576869 creator A5048243928 @default.
- W4293576869 creator A5054850914 @default.
- W4293576869 creator A5063826622 @default.
- W4293576869 creator A5065021697 @default.
- W4293576869 creator A5085106104 @default.
- W4293576869 creator A5086139902 @default.
- W4293576869 date "2022-08-30" @default.
- W4293576869 modified "2023-10-14" @default.
- W4293576869 title "Development of a novel method for measuring tissue oxygen pressure to improve the hypoxic condition in subcutaneous islet transplantation" @default.
- W4293576869 cites W1597403638 @default.
- W4293576869 cites W1965953367 @default.
- W4293576869 cites W1972182056 @default.
- W4293576869 cites W1978288865 @default.
- W4293576869 cites W1984840441 @default.
- W4293576869 cites W1988378648 @default.
- W4293576869 cites W1990341094 @default.
- W4293576869 cites W1995595371 @default.
- W4293576869 cites W1996607161 @default.
- W4293576869 cites W2005414156 @default.
- W4293576869 cites W2011007681 @default.
- W4293576869 cites W2036022664 @default.
- W4293576869 cites W2038784204 @default.
- W4293576869 cites W2046176025 @default.
- W4293576869 cites W2064625295 @default.
- W4293576869 cites W2066159327 @default.
- W4293576869 cites W2066795948 @default.
- W4293576869 cites W2068454669 @default.
- W4293576869 cites W2069427034 @default.
- W4293576869 cites W2070908159 @default.
- W4293576869 cites W2082176642 @default.
- W4293576869 cites W2118677249 @default.
- W4293576869 cites W2123216909 @default.
- W4293576869 cites W2129568900 @default.
- W4293576869 cites W2133987054 @default.
- W4293576869 cites W2137174600 @default.
- W4293576869 cites W2144283470 @default.
- W4293576869 cites W2149936611 @default.
- W4293576869 cites W2172305142 @default.
- W4293576869 cites W2173141813 @default.
- W4293576869 cites W2324028233 @default.
- W4293576869 cites W2327584905 @default.
- W4293576869 cites W2328786770 @default.
- W4293576869 cites W2331768284 @default.
- W4293576869 cites W2534595742 @default.
- W4293576869 cites W2554650020 @default.
- W4293576869 cites W2754300466 @default.
- W4293576869 cites W2763654803 @default.
- W4293576869 cites W2791332675 @default.
- W4293576869 cites W2795386665 @default.
- W4293576869 cites W2802427215 @default.
- W4293576869 cites W2885954000 @default.
- W4293576869 cites W2901269618 @default.
- W4293576869 cites W2944528604 @default.
- W4293576869 cites W2968575438 @default.
- W4293576869 cites W3131362449 @default.
- W4293576869 cites W4206112125 @default.
- W4293576869 cites W71619780 @default.
- W4293576869 doi "https://doi.org/10.1038/s41598-022-19189-2" @default.
- W4293576869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36042259" @default.
- W4293576869 hasPublicationYear "2022" @default.
- W4293576869 type Work @default.
- W4293576869 citedByCount "3" @default.
- W4293576869 countsByYear W42935768692023 @default.
- W4293576869 crossrefType "journal-article" @default.
- W4293576869 hasAuthorship W4293576869A5002986571 @default.
- W4293576869 hasAuthorship W4293576869A5004774783 @default.
- W4293576869 hasAuthorship W4293576869A5011244445 @default.
- W4293576869 hasAuthorship W4293576869A5013785901 @default.
- W4293576869 hasAuthorship W4293576869A5020864858 @default.
- W4293576869 hasAuthorship W4293576869A5048243928 @default.
- W4293576869 hasAuthorship W4293576869A5054850914 @default.
- W4293576869 hasAuthorship W4293576869A5063826622 @default.
- W4293576869 hasAuthorship W4293576869A5065021697 @default.
- W4293576869 hasAuthorship W4293576869A5085106104 @default.
- W4293576869 hasAuthorship W4293576869A5086139902 @default.
- W4293576869 hasBestOaLocation W42935768691 @default.
- W4293576869 hasConcept C126322002 @default.
- W4293576869 hasConcept C134018914 @default.
- W4293576869 hasConcept C136229726 @default.
- W4293576869 hasConcept C141071460 @default.
- W4293576869 hasConcept C142724271 @default.
- W4293576869 hasConcept C165220095 @default.
- W4293576869 hasConcept C16685009 @default.
- W4293576869 hasConcept C178596483 @default.
- W4293576869 hasConcept C178790620 @default.
- W4293576869 hasConcept C185592680 @default.
- W4293576869 hasConcept C2777300098 @default.
- W4293576869 hasConcept C2911091166 @default.
- W4293576869 hasConcept C540031477 @default.
- W4293576869 hasConcept C555293320 @default.
- W4293576869 hasConcept C70289976 @default.
- W4293576869 hasConcept C71924100 @default.
- W4293576869 hasConcept C7836513 @default.