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• W4293578981 abstract "Background and Aims : Circulating microRNAs as a component of such epigenetic mechanism of posttranscriptional regulation of mRNA translation may serve as blood biomarkers of CVDs, moreover, the study of circulating miRNAs may help to identify potential therapeutic targets. We investigated changes in the serum level of 4 circulated microRNAs (miR-33a, miR-33b, miR-146a, and miR-146b) in patients with coronary artery disease and disorders of carbohydrate metabolism under the influence of up-titrated doses of two widely used statins (atorvastatin and rosuvastatin).Methods: RNA was isolated from blood plasma samples obtained from clinical trial participants (n=16; 14 males and 2 females; mean age64.25±9.19) just before and 30days after treatment. To investigate microRNAs levels, RT-qPCR analysis was performed. Exogenous cel-miR-39 was used as a reference. Changes in miRs circulating levels were evaluated, the significance level p ≤0.05.Results: All Ct’s for each patient, obtained by RT-qPCR, normalized on Ct for control. Statistically significant changes in expression noted: decreasing for miR-33a(p=0.0043) and -33b(p=0.0009); increasing for miR-146a(p=0.0054). For miR-146b no significant changes were observed (p=0.5014).Conclusions: Our study has demonstrated that increasing doses of Rosuvastatin and Atorvastatin may influence miR-33a/b (decreasing) and miR-146a (increasing) serum levels. This data pointed that the pharmacological effect of up-titrated doses may also be explained additional pleiotropic effects on key serum miRNAs involved in the regulation of lipid metabolism and inflammation. Background and Aims : Circulating microRNAs as a component of such epigenetic mechanism of posttranscriptional regulation of mRNA translation may serve as blood biomarkers of CVDs, moreover, the study of circulating miRNAs may help to identify potential therapeutic targets. We investigated changes in the serum level of 4 circulated microRNAs (miR-33a, miR-33b, miR-146a, and miR-146b) in patients with coronary artery disease and disorders of carbohydrate metabolism under the influence of up-titrated doses of two widely used statins (atorvastatin and rosuvastatin). Methods: RNA was isolated from blood plasma samples obtained from clinical trial participants (n=16; 14 males and 2 females; mean age64.25±9.19) just before and 30days after treatment. To investigate microRNAs levels, RT-qPCR analysis was performed. Exogenous cel-miR-39 was used as a reference. Changes in miRs circulating levels were evaluated, the significance level p ≤0.05. Results: All Ct’s for each patient, obtained by RT-qPCR, normalized on Ct for control. Statistically significant changes in expression noted: decreasing for miR-33a(p=0.0043) and -33b(p=0.0009); increasing for miR-146a(p=0.0054). For miR-146b no significant changes were observed (p=0.5014). Conclusions: Our study has demonstrated that increasing doses of Rosuvastatin and Atorvastatin may influence miR-33a/b (decreasing) and miR-146a (increasing) serum levels. This data pointed that the pharmacological effect of up-titrated doses may also be explained additional pleiotropic effects on key serum miRNAs involved in the regulation of lipid metabolism and inflammation." @default.
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• W4293578981 date "2022-08-01" @default.
• W4293578981 modified "2023-09-29" @default.
• W4293578981 title "Effect of increasing doses of statins on the level of serum micrornas involved in reverse cholesterol transport and inflammation" @default.
• W4293578981 doi "https://doi.org/10.1016/j.atherosclerosis.2022.06.743" @default.
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