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- W4293581566 abstract "A four-step synthesis of five- and six-membered E/F ring spiroethers from tigogenin has been developed. An efficient strategy that features bis-Grignard reaction of dinorcholanic lactone with appropriate bis(bromomagnesio)alkanes followed by acid-mediated spirocyclization was employed to construct a new class of steroid compounds having E and F ring junction as an oxa-carbacyclic system. The synthesized carbaanalogs interact with liposomes and albumin, and also exhibit antibacterial and antifungal activity, demonstrating their pharmacological potential." @default.
- W4293581566 created "2022-08-30" @default.
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- W4293581566 date "2022-11-01" @default.
- W4293581566 modified "2023-10-18" @default.
- W4293581566 title "Concise synthesis of E/F ring spiroethers from tigogenin. Carbaanalogs of steroidal sapogenins and their biological activity" @default.
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- W4293581566 doi "https://doi.org/10.1016/j.jsbmb.2022.106174" @default.
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