Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293582170> ?p ?o ?g. }
- W4293582170 abstract "Abstract Neuroinflammation is the main pathological mechanism of cognitive dysfunction caused by neurodegenerative diseases, and effective preventive and therapeutic measures are not available. We predicted the key targets of gastrodin's effects upon neuroinflammation through Network Pharmacology and molecular docking. Then the predicted targets were used to study how gastrodin affected cognitive dysfunction triggered by lipopolysaccharide-induced neuroinflammation in rats and its mechanisms. Three-month-old male rats were intraperitoneally injected with lipopolysaccharide for 3 days (d), 7 d and 14 d respectively. Gastrodin improved learning and memory ability of rats with neuroinflammation. Lipopolysaccharide enhanced the levels of pro-inflammatory cytokines, such as TNF-α, IL-1β and IL-6, in rat hippocampus, which could be reversed by gastrodin. Gastrodin also inhibited the activation of microglia. Our findings suggested that gastrodin exerted neuroprotective effects in rats with neuroinflammation by impacting the TLR4-NF-kB-NLRP3 pathway. Therefore, gastrodin may be a potential therapeutic agent for neuroinflammation-induced cognitive dysfunction." @default.
- W4293582170 created "2022-08-30" @default.
- W4293582170 creator A5004599074 @default.
- W4293582170 creator A5027687694 @default.
- W4293582170 creator A5036553606 @default.
- W4293582170 creator A5038908271 @default.
- W4293582170 creator A5050844765 @default.
- W4293582170 creator A5075609986 @default.
- W4293582170 creator A5091435405 @default.
- W4293582170 creator A5043041991 @default.
- W4293582170 date "2022-08-30" @default.
- W4293582170 modified "2023-09-27" @default.
- W4293582170 title "Gastrodin improves neuroinflammation-induced cognitive dysfunction in rats by regulating NLRP3 inflammasome" @default.
- W4293582170 cites W183710148 @default.
- W4293582170 cites W1989531578 @default.
- W4293582170 cites W1999070279 @default.
- W4293582170 cites W2018974307 @default.
- W4293582170 cites W2030692340 @default.
- W4293582170 cites W2032879843 @default.
- W4293582170 cites W2033719672 @default.
- W4293582170 cites W2049125400 @default.
- W4293582170 cites W2078252006 @default.
- W4293582170 cites W2080375278 @default.
- W4293582170 cites W2108435419 @default.
- W4293582170 cites W2158232675 @default.
- W4293582170 cites W2410955968 @default.
- W4293582170 cites W2468501494 @default.
- W4293582170 cites W2527645962 @default.
- W4293582170 cites W2559588208 @default.
- W4293582170 cites W2567737372 @default.
- W4293582170 cites W2569931142 @default.
- W4293582170 cites W2573860436 @default.
- W4293582170 cites W2619332462 @default.
- W4293582170 cites W2768388261 @default.
- W4293582170 cites W2770331037 @default.
- W4293582170 cites W2782074226 @default.
- W4293582170 cites W2782357499 @default.
- W4293582170 cites W2787368117 @default.
- W4293582170 cites W2800267196 @default.
- W4293582170 cites W2800724199 @default.
- W4293582170 cites W2805962694 @default.
- W4293582170 cites W2807221969 @default.
- W4293582170 cites W2810902921 @default.
- W4293582170 cites W2892864052 @default.
- W4293582170 cites W2911127509 @default.
- W4293582170 cites W2912663016 @default.
- W4293582170 cites W2916257061 @default.
- W4293582170 cites W2948718688 @default.
- W4293582170 cites W2951544248 @default.
- W4293582170 cites W2960015172 @default.
- W4293582170 cites W2965793313 @default.
- W4293582170 cites W3009127349 @default.
- W4293582170 cites W3025128382 @default.
- W4293582170 cites W3098323141 @default.
- W4293582170 cites W3122153668 @default.
- W4293582170 doi "https://doi.org/10.21203/rs.3.rs-1925938/v1" @default.
- W4293582170 hasPublicationYear "2022" @default.
- W4293582170 type Work @default.
- W4293582170 citedByCount "0" @default.
- W4293582170 crossrefType "posted-content" @default.
- W4293582170 hasAuthorship W4293582170A5004599074 @default.
- W4293582170 hasAuthorship W4293582170A5027687694 @default.
- W4293582170 hasAuthorship W4293582170A5036553606 @default.
- W4293582170 hasAuthorship W4293582170A5038908271 @default.
- W4293582170 hasAuthorship W4293582170A5043041991 @default.
- W4293582170 hasAuthorship W4293582170A5050844765 @default.
- W4293582170 hasAuthorship W4293582170A5075609986 @default.
- W4293582170 hasAuthorship W4293582170A5091435405 @default.
- W4293582170 hasBestOaLocation W42935821701 @default.
- W4293582170 hasConcept C126322002 @default.
- W4293582170 hasConcept C15744967 @default.
- W4293582170 hasConcept C169760540 @default.
- W4293582170 hasConcept C185592680 @default.
- W4293582170 hasConcept C203014093 @default.
- W4293582170 hasConcept C25498285 @default.
- W4293582170 hasConcept C2776070231 @default.
- W4293582170 hasConcept C2776151105 @default.
- W4293582170 hasConcept C2776914184 @default.
- W4293582170 hasConcept C2777209026 @default.
- W4293582170 hasConcept C2778401633 @default.
- W4293582170 hasConcept C2778754761 @default.
- W4293582170 hasConcept C2779830541 @default.
- W4293582170 hasConcept C2781248740 @default.
- W4293582170 hasConcept C43617362 @default.
- W4293582170 hasConcept C71924100 @default.
- W4293582170 hasConcept C87753298 @default.
- W4293582170 hasConcept C98274493 @default.
- W4293582170 hasConceptScore W4293582170C126322002 @default.
- W4293582170 hasConceptScore W4293582170C15744967 @default.
- W4293582170 hasConceptScore W4293582170C169760540 @default.
- W4293582170 hasConceptScore W4293582170C185592680 @default.
- W4293582170 hasConceptScore W4293582170C203014093 @default.
- W4293582170 hasConceptScore W4293582170C25498285 @default.
- W4293582170 hasConceptScore W4293582170C2776070231 @default.
- W4293582170 hasConceptScore W4293582170C2776151105 @default.
- W4293582170 hasConceptScore W4293582170C2776914184 @default.
- W4293582170 hasConceptScore W4293582170C2777209026 @default.
- W4293582170 hasConceptScore W4293582170C2778401633 @default.
- W4293582170 hasConceptScore W4293582170C2778754761 @default.
- W4293582170 hasConceptScore W4293582170C2779830541 @default.