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• W4293584873 abstract "Background and Aims : The use of animal models in atherosclerotic lesions has improved our understanding of atherosclerosis pathophysiology. We sought to develop an easily reproducible and inexpensive experimental rabbit femoral artery model of intermediate stage atherosclerosis with moderate stenosis (< 40%).Methods: Intermediate stage atherosclerosis was induced at the right femoral artery in White New Zealand rabbits using B- mode ultrasound- guided extracorporeal high intensity pulsed focused ultrasound (F= 750 KHz, I= 120 W/cm2)- mediated cavitation- induced injury combined with a 1% cholesterol-rich diet injury in five weeks. Ultrasonography and histopathology was evaluated after five weeks.Results: Histopathologic evaluation revealed progressive smooth muscle cells and extracellular lipid droplets proliferation in the intimal layer, resulting in the formation of intermediate stage of atherosclerosis. Percentage of luminal- cross sectional area of stenosis was 34 ± 5.31 compared with the other groups (P < 0.05). Results from ultrasonography and histopathology showed a significant increase in the mean value for arterial Wall Thickness (WT),Peak Systolic Velocity (PSV), End Diastolic Velocity (EDV), Mean Velocity (MV), Resistance Index (RI), Pulsatility Index (PI) and significant reduction in the mean value for arterial Lumen Diameter (LD), blood Volume Flow (VF) at the stenotic region in the atherosclerotic group compared with the other groups (p < 0.05).Conclusions: We successfully produced an easily reproducible and inexpensive experimental rabbit femoral artery model of intermediate stage atherosclerosis with moderate stenosis using B- mode ultrasound- guided high intensity pulsed focused ultrasound, similar to the condition seen in human subjects. This condition in rabbits can be properly assessed by ultrasonography. Background and Aims : The use of animal models in atherosclerotic lesions has improved our understanding of atherosclerosis pathophysiology. We sought to develop an easily reproducible and inexpensive experimental rabbit femoral artery model of intermediate stage atherosclerosis with moderate stenosis (< 40%). Methods: Intermediate stage atherosclerosis was induced at the right femoral artery in White New Zealand rabbits using B- mode ultrasound- guided extracorporeal high intensity pulsed focused ultrasound (F= 750 KHz, I= 120 W/cm2)- mediated cavitation- induced injury combined with a 1% cholesterol-rich diet injury in five weeks. Ultrasonography and histopathology was evaluated after five weeks. Results: Histopathologic evaluation revealed progressive smooth muscle cells and extracellular lipid droplets proliferation in the intimal layer, resulting in the formation of intermediate stage of atherosclerosis. Percentage of luminal- cross sectional area of stenosis was 34 ± 5.31 compared with the other groups (P < 0.05). Results from ultrasonography and histopathology showed a significant increase in the mean value for arterial Wall Thickness (WT),Peak Systolic Velocity (PSV), End Diastolic Velocity (EDV), Mean Velocity (MV), Resistance Index (RI), Pulsatility Index (PI) and significant reduction in the mean value for arterial Lumen Diameter (LD), blood Volume Flow (VF) at the stenotic region in the atherosclerotic group compared with the other groups (p < 0.05). Conclusions: We successfully produced an easily reproducible and inexpensive experimental rabbit femoral artery model of intermediate stage atherosclerosis with moderate stenosis using B- mode ultrasound- guided high intensity pulsed focused ultrasound, similar to the condition seen in human subjects. This condition in rabbits can be properly assessed by ultrasonography." @default.
• W4293584873 created "2022-08-30" @default.
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• W4293584873 date "2022-08-01" @default.
• W4293584873 modified "2023-09-27" @default.
• W4293584873 title "A new animal femoral artery model of localized intermediate stage of atherosclerosis using focused ultrasound- mediated inertial cavitation- induced injury and high- cholesterol diet injury" @default.
• W4293584873 doi "https://doi.org/10.1016/j.atherosclerosis.2022.06.321" @default.
• W4293584873 hasPublicationYear "2022" @default.
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