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• W4293584985 abstract "Background and Aims : CKD patients have a high prevalence of LVH and an increased cardiovascular risk. In this study we have assessed the prevalence of left ventricular hypertrophy (LVH) and left ventricular geometry in a group of 293 patients with high blood pressure and with stage 2–5 chronic kidney disease (CKD), compared with 289 essential hypertensive patients with normal renal function.Methods: All patients underwent echocardiographic examination. Patients on stage 1 CKD, dialysis treatment, or with cardiovascular diseases were excluded.Results: LVH was observed in 62.8% of patients with CKD and in 51.9% of essential hypertensive patients (P<0.0001). We found increasingly higher left ventricular diameters, thicknesses, and mass from stage 2 to 5 CKD. Distribution of concentric and eccentric LVH was not very different between the two groups. However, after introducing mixed hypertrophy, the difference between the two groups group was disclosed (P=0.027). Multiple regression analysis confirmed that the association between renal function and left ventricular mass (β -0.287; P<0.0001) was independent by potential confounders. Diastolic function was significantly worse in patients with CKD, especially in more advanced stages.Conclusions: Our study confirms that LVH is highly prevalent in patients with CKD, especially by using the most recent cut off; in this population, LVH is often characterized by the simultaneous increase of wall thicknesses and diameters with negative effects on diastolic function. Background and Aims : CKD patients have a high prevalence of LVH and an increased cardiovascular risk. In this study we have assessed the prevalence of left ventricular hypertrophy (LVH) and left ventricular geometry in a group of 293 patients with high blood pressure and with stage 2–5 chronic kidney disease (CKD), compared with 289 essential hypertensive patients with normal renal function. Methods: All patients underwent echocardiographic examination. Patients on stage 1 CKD, dialysis treatment, or with cardiovascular diseases were excluded. Results: LVH was observed in 62.8% of patients with CKD and in 51.9% of essential hypertensive patients (P<0.0001). We found increasingly higher left ventricular diameters, thicknesses, and mass from stage 2 to 5 CKD. Distribution of concentric and eccentric LVH was not very different between the two groups. However, after introducing mixed hypertrophy, the difference between the two groups group was disclosed (P=0.027). Multiple regression analysis confirmed that the association between renal function and left ventricular mass (β -0.287; P<0.0001) was independent by potential confounders. Diastolic function was significantly worse in patients with CKD, especially in more advanced stages. Conclusions: Our study confirms that LVH is highly prevalent in patients with CKD, especially by using the most recent cut off; in this population, LVH is often characterized by the simultaneous increase of wall thicknesses and diameters with negative effects on diastolic function." @default.
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• W4293584985 date "2022-08-01" @default.
• W4293584985 modified "2023-09-29" @default.
• W4293584985 title "Left ventricular hypertrophy in chronic kidney disease" @default.
• W4293584985 doi "https://doi.org/10.1016/j.atherosclerosis.2022.06.811" @default.
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