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• W4293585352 abstract "Background and Aims : To study the association of late adverse events (LAEs) after isolated coronary artery bypass grafting (CABG) in patients with stable coronary artery disease (SCAD) with compliance to statin therapy (ST).Methods: 155 SCAD patients (mean age 61±8 years; 139 (89,7%) males) after isolated CABG were followed over a period of 12 months after surgery. Twenty-four (15,8%) of 152 patients presented with LAEs (totally, 29 cases; no data in 3 patients). The LAEs profile was predominantly presented by the cases of heart failure progression and left ventricular (LV) ejection fraction (EF) decline >10% (14 cases [48%]). At one year follow-up, 4 patients died. Data on long-term compliance with discharge ST were available in 151 patients: pattern 1 (P1) – withdrawal of previously prescribed ST (n=22), P2 – continuation of low- or moderate-intensity ST, irrespective to its discharge intensity (n=105), and P3 – continuation of previously prescribed high intensity ST (n=24).Results: Patients with LAEs (vs. no-LAEs, respectively) were characterized by more prevalent P1 cases (43,5% vs. 9,4%; p<0,001). The continuation of low-to-moderate-intensity ST (P2) tended to be more frequent among patients without LAEs (vs. LAEs, respectively): 72,6% vs. 52,2% (р=0,082). The P3 frequency did not differ significantly between both groups of comparison.Conclusions: The LAEs after CABG in patients with SCAD were associated with more frequent withdrawal of previously prescribed ST. Preserving compliance to statin therapy is an important priority at long-term observation after CABG. Background and Aims : To study the association of late adverse events (LAEs) after isolated coronary artery bypass grafting (CABG) in patients with stable coronary artery disease (SCAD) with compliance to statin therapy (ST). Methods: 155 SCAD patients (mean age 61±8 years; 139 (89,7%) males) after isolated CABG were followed over a period of 12 months after surgery. Twenty-four (15,8%) of 152 patients presented with LAEs (totally, 29 cases; no data in 3 patients). The LAEs profile was predominantly presented by the cases of heart failure progression and left ventricular (LV) ejection fraction (EF) decline >10% (14 cases [48%]). At one year follow-up, 4 patients died. Data on long-term compliance with discharge ST were available in 151 patients: pattern 1 (P1) – withdrawal of previously prescribed ST (n=22), P2 – continuation of low- or moderate-intensity ST, irrespective to its discharge intensity (n=105), and P3 – continuation of previously prescribed high intensity ST (n=24). Results: Patients with LAEs (vs. no-LAEs, respectively) were characterized by more prevalent P1 cases (43,5% vs. 9,4%; p<0,001). The continuation of low-to-moderate-intensity ST (P2) tended to be more frequent among patients without LAEs (vs. LAEs, respectively): 72,6% vs. 52,2% (р=0,082). The P3 frequency did not differ significantly between both groups of comparison. Conclusions: The LAEs after CABG in patients with SCAD were associated with more frequent withdrawal of previously prescribed ST. Preserving compliance to statin therapy is an important priority at long-term observation after CABG." @default.
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• W4293585352 date "2022-08-01" @default.
• W4293585352 modified "2023-09-25" @default.
• W4293585352 title "Late adverse events after surgical revascularization in patients with stable coronary artery disease: Association with compliance to statin therapy" @default.
• W4293585352 doi "https://doi.org/10.1016/j.atherosclerosis.2022.06.972" @default.
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